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Prevalence of hyperandrogenemia in the polycystic ovary syndrome diagnosed by the National Institutes of Health 1990 criteria.

Abstract：

OBJECTIVE:To determine the prevalence of elevated total and free T, and DHEAS, alone and in combination, in patients with polycystic ovary syndrome (PCOS). DESIGN:Cross-sectional analysis. SETTING:Tertiary care academic medical center. PATIENT(S):Seven hundred twenty patients diagnosed with PCOS according to the National Institutes of Health 1990 criteria. INTERVENTION(S):History, physical examination, and blood sampling. MAIN OUTCOME MEASURE(S):Hyperandrogenemia, defined as at least one androgen value above the 95th percentile of 98 healthy control women (i.e., total T >88 ng/dL, free T >0.75 ng/dL, and DHEAS >2,750 ng/mL). RESULT(S):A total of 716 subjects with PCOS were included. The overall prevalence of hyperandrogenemia in PCOS was 75.3%. Supranormal levels of free T were present in 57.6%, of total T in 33.0%, and of DHEAS in 32.7% of patients with PCOS. When assessing the prevalence of two abnormal values, the prevalence of simultaneously elevated androgens was lowest with total T and DHEAS (1.7%) and highest with total T and free T (20.4%). Altogether, simultaneous elevations in all three markers were found in 8.7% of subjects with PCOS. CONCLUSION(S):Approximately three-fourths of patients with PCOS diagnosed by the National Institutes of Health 1990 criteria have evidence of hyperandrogenemia; the single most predictive assay was the measurement of free T with approximately 60% of patients demonstrating supranormal levels.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Huang A,Brennan K,Azziz R

doi

10.1016/j.fertnstert.2008.12.138

subject

Has Abstract

pub_date

2010-04-01 00:00:00

pages

1938-41

issue

6

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(08)04817-6

journal_volume

93

pub_type

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