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Assessing brain-derived neurotrophic factor as a novel clinical marker of endometriosis.

Abstract：

OBJECTIVE:To evaluate novel clinical markers of endometriosis including the neurotrophins brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), and neurotrophin 4/5 (NT4/5) and compare them to others previously reported in the literature including cancer antigen 125 (CA-125) and C-reactive protein (CRP). DESIGN:Prospective study. SETTING:University hospital. PATIENT(S):One hundred thirty-eight women were prospectively and consecutively recruited (April 2011-April 2015; cases: undergoing endometriosis surgery, n = 96; controls: benign gynecological surgery, n = 24 combined with healthy women, no history of pelvic pain, not undergoing surgery, n = 18). INTERVENTION(S):Collection of peripheral blood, gynecological and demographic information, eutopic biopsy in women undergoing laparoscopy. MAIN OUTCOME MEASURE(S):Circulating BDNF, NGF, NT4/5, CA-125, and CRP were quantified by ELISA. RESULT(S):Plasma concentrations of BDNF were significantly greater in women with endometriosis (1,091.9 pg/mL [640.4-1,683.1]; n = 68, untreated) than in controls (731.4 pg/mL [352.1-1,176.2]; n = 36), whereas circulating NGF, NT4/5, CA-125, and CRP were not different. When assessed for their ability to differentiate between women with revised Classification of the American Society of Reproductive Medicine stage 1 and 2 or stage 3 and 4 disease and controls, BDNF was the only putative marker able to identify stage 1 and 2 disease, with a sensitivity and specificity of 91.7% and 69.4%, respectively, using an arbitrary cutoff value of 1,000 pg/mL. We also demonstrated that circulating BDNF in women with endometriosis who were receiving ovarian suppression for disease was equivalent to that in the control group. This suggests that BDNF may also offer the opportunity to monitor patient response to treatment. CONCLUSION(S):Plasma BDNF is a potentially useful clinical marker of endometriosis that is superior to NGF, NT4/5, CA-125, and CRP.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Wessels JM,Kay VR,Leyland NA,Agarwal SK,Foster WG

doi

10.1016/j.fertnstert.2015.09.003

subject

Has Abstract

pub_date

2016-01-01 00:00:00

pages

119-28.e1-5

issue

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(15)01889-0

journal_volume

105

pub_type

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Assessing brain-derived neurotrophic factor as a novel clinical marker of endometriosis.