A multiparametric analysis of endometrial estrogen and progesterone receptors after the postovulatory administration of mifepristone.

Abstract:

:A double-blind randomized study was performed in two groups of eight normally cycling patients: group I received 10 mg/d of RU486 for 4 days from the date of ovulation and group II received a placebo. On day +5, cytosol and endometrial estrogen receptors (ERs), and progesterone receptors (PRs) were analyzed by radioligand binding assay as well as by enzyme immunochemistry. Histologic studies showed that all the endometria of group I were abnormal (luteal insufficiency and/or E/P imbalance). The nuclear PR levels were significantly higher in group I (843 +/- 422 fmol/mg) deoxyribonucleic (DNA) compared with 482 +/- 232 fmol/mg DNA in group II. Immunohistochemical study showed that ER and PR staining was higher for both glands and stroma in group I (52% and 72% for the respective receptors), compared with the receptor-immunostained surface observed in group II, which was reduced to 40% for ER and to 4% for PR. This study demonstrates that RU486 administered in the immediate postovulatory period blocks normal tissue evolution in the follicular phase as well as the processing of PR.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Berthois Y,Salat-Baroux J,Cornet D,De Brux J,Kopp F,Martin PM

doi

10.1016/s0015-0282(16)54183-1

subject

Has Abstract

pub_date

1991-03-01 00:00:00

pages

547-54

issue

3

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(16)54183-1

journal_volume

55

pub_type

临床试验,杂志文章,随机对照试验
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    更新日期:2011-02-01 00:00:00

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    authors: Ota H,Igarashi S,Kato N,Tanaka T

    更新日期:2000-08-01 00:00:00

  • Occurrence of a spontaneous luteinizing hormone surge in superovulated cycles--predictive value of serum progesterone.

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    更新日期:1988-01-01 00:00:00

  • Ectopic pregnancy in unrepaired distal tubal remnant after contralateral tubal anastomosis.

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    journal_title:Fertility and sterility

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    abstract:OBJECTIVE:To assess the effect of age and ovarian function on endometrial receptivity. DESIGN:Retrospective comparison between standard IVF and ovum donation in younger and older patients (< 40 and > or = 40 years of age, respectively). PATIENTS:In standard IVF, there were 325 transfer cycles in older patients and 1,...

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    更新日期:1993-08-01 00:00:00

  • Expression and localization of transcription factor Ets-1 in the rat ovary during the estrous cycle and pregnancy.

    abstract:OBJECTIVE:To examine the expression and localization of Ets-1 in the rat ovary during the estrous cycle and pregnancy, and to investigate its effects on ovarian function. DESIGN:Prospective, randomized study. SETTING:Department of Physiology at Harbin Medical University. ANIMAL(S):Pubertal female Wistar rats. INTER...

    journal_title:Fertility and sterility

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    更新日期:2009-05-01 00:00:00

  • Fertility treatment when the prognosis is very poor or futile.

    abstract::The Ethics Committee recommends development of evidence-based policies that are patient centered for each IVF center. In most cases, the provision of futile therapies is not ethically justifiable. For those treatments with very poor success rates, clinicians must be vigilant in their presentation of risks, benefits, a...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,评审

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    更新日期:2009-10-01 00:00:00

  • Efficacy of the second micro-testicular sperm extraction after failed first micro-testicular sperm extraction in men with nonobstructive azoospermia.

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    pub_type: 杂志文章

    doi:10.1016/j.fertnstert.2020.10.005

    authors: Özman O,Tosun S,Bayazıt N,Cengiz S,Bakırcıoğlu ME

    更新日期:2020-12-23 00:00:00

  • Is "microscopic" peritoneal endometriosis invisible?

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    journal_title:Fertility and sterility

    pub_type: 杂志文章

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    authors: Redwine DB

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    journal_title:Fertility and sterility

    pub_type: 杂志文章

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    authors: Stegmann BJ,Sinaii N,Liu S,Segars J,Merino M,Nieman LK,Stratton P

    更新日期:2008-06-01 00:00:00

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    journal_title:Fertility and sterility

    pub_type: 杂志文章

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    更新日期:1989-05-01 00:00:00

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    pub_type: 杂志文章

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    更新日期:2009-04-01 00:00:00

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    journal_title:Fertility and sterility

    pub_type: 杂志文章,评审

    doi:10.1016/j.fertnstert.2007.12.041

    authors: Windham G,Fenster L

    更新日期:2008-02-01 00:00:00

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    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/j.fertnstert.2003.11.014

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    更新日期:2004-03-01 00:00:00

  • The psychological effects of multifetal pregnancy reduction.

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    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:

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    更新日期:1995-07-01 00:00:00

  • Apoptosis and expression of Bcl-2 and Bax in eutopic endometrium from women with endometriosis.

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    journal_title:Fertility and sterility

    pub_type: 杂志文章

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    更新日期:2000-10-01 00:00:00

  • Fluorescein isothiocyanate conjugate-wheat germ agglutinin staining of human spermatozoa and fertilization in vitro.

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    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/s0015-0282(16)57499-8

    authors: Gabriel LK,Franken DR,Van der Horst G,Kruger TF

    更新日期:1995-04-01 00:00:00

  • Recovery of microorganisms from the pelvic cavity after intracervical or intrauterine artificial insemination.

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    journal_title:Fertility and sterility

    pub_type: 杂志文章

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    更新日期:1986-07-01 00:00:00

  • Estrogen receptor thymine-adenine dinucleotide repeat polymorphism is associated with susceptibility to leiomyoma.

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    journal_title:Fertility and sterility

    pub_type: 杂志文章

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    authors: Hsieh YY,Chang CC,Tsai FJ,Tsai HD,Yeh LS,Lin CC,Tsai CH

    更新日期:2003-01-01 00:00:00

  • Testicular reserve of testosterone precursors in primary testicular failure.

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    journal_title:Fertility and sterility

    pub_type: 杂志文章

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    更新日期:1982-07-01 00:00:00

  • Fertility in a female with mosaic trisomy 8.

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    pub_type: 杂志文章

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    更新日期:2003-01-01 00:00:00

  • Characterization of aneuploidy rates, protamine levels, ultrastructure, and functional ability of round-headed sperm from two siblings and implications for intracytoplasmic sperm injection.

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    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/s0015-0282(98)00498-1

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    更新日期:1999-03-01 00:00:00

  • Relook hysteroscopy after antitubercular therapy.

    abstract::Hysteroscopic visualization of the endometrium after 6 months of antitubercular therapy showed an improvement in the mucosal morphology. A closer visualization at increased magnification was helpful in demonstrating the remnants of a healing tubercular pathology after antitubercular therapy. ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

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    更新日期:2008-03-01 00:00:00

  • Failure of seminal plasma to enter the uterus and oviducts of the rabbit following artificial insemination.

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    journal_title:Fertility and sterility

    pub_type: 杂志文章

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    更新日期:1977-06-01 00:00:00

  • Adhesion formation from release of dermoid contents in the peritoneal cavity and effect of copious lavage: a prospective, randomized, blinded, controlled study in a rabbit model.

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    journal_title:Fertility and sterility

    pub_type: 杂志文章

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    authors: Fielder EP,Guzick DS,Guido R,Kanbour-Shakir A,Krasnow JS

    更新日期:1996-04-01 00:00:00

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    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/s0015-0282(00)01695-2

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    更新日期:2001-02-01 00:00:00

  • Assisted reproductive technologies in Canada: 2005 results from the Canadian Assisted Reproductive Technologies Register.

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    pub_type: 杂志文章

    doi:10.1016/j.fertnstert.2008.02.125

    authors: Gunby J,Bissonnette F,Librach C,Cowan L,IVF Directors Group of the Canadian Fertility and Andrology Society.

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    pub_type: 杂志文章,随机对照试验

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    更新日期:2007-05-01 00:00:00