Abstract:
OBJECTIVE:To compare the expression protein profile of seminal plasma from infertile men with oligoasthenoteratozoospermia (OAT) due to oxidative stress with that of healthy, fertile men to determine the proteins indicative of infertility. DESIGN:Experimental study. SETTING:University hospital and research institute. PATIENT(S):Semen samples from 11 healthy, fertile (according to the 1999 World Health Organization criteria) male volunteers and 11 infertile idiopathic oligoasthenoteratozoospermia (iOAT) patients. INTERVENTION(S):None. MAIN OUTCOME MEASURE(S):Proteomic analysis performed by liquid chromatography mass spectrometry on a hybrid linear trap quadrupole Orbitrap Velos mass spectrometer, carbonylation assay to determine degree of oxidative stress, semiquantitative proteomic analysis, gene ontology, and pathway analysis. RESULT(S):A total of 2,489 proteins were identified from seminal plasma, which represents the highest number of unique proteins identified to date. Twenty-four proteins were determined as ≥ 1.5-fold up-regulated in the infertile iOAT males as compared with the fertile controls; and 27 proteins from iOAT patients only were identified as common across all analyses. Only five of the proteins were shared between these two groups. CONCLUSION(S):A panel of 46 proteins were identified in patients with iOAT that are potential candidates in understanding the etiology of OAT due to oxidative stress.
journal_name
Fertil Steriljournal_title
Fertility and sterilityauthors
Herwig R,Knoll C,Planyavsky M,Pourbiabany A,Greilberger J,Bennett KLdoi
10.1016/j.fertnstert.2013.03.048subject
Has Abstractpub_date
2013-08-01 00:00:00pages
355-66.e2issue
2eissn
0015-0282issn
1556-5653pii
S0015-0282(13)00494-9journal_volume
100pub_type
杂志文章abstract:OBJECTIVE:To study the effect of frozen embryo transfer (FET) preparation protocol on incidence of subchorionic hematoma (SCH) and serum hormone levels. DESIGN:Retrospective cohort study. SETTING:University-affiliated fertility center. PATIENT(S):Patients who underwent FET at the New York University Langone Fertilit...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2020.04.040
更新日期:2020-09-01 00:00:00
abstract::Nineteen vasectomized men were followed for 21 to 42 months after surgery, and their sera were tested for the presence of HL-A lymphocytoxic antibodies. In a previous study, the sera of two of these men had shown a definite increase in serum reactivity 6 to 12 months after surgery. Only one of the nineteen tested in t...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)42494-5
更新日期:1977-04-01 00:00:00
abstract:OBJECTIVE:To investigate the utility of random anti-Müllerian hormone (AMH) in assessing ovarian response among women with diminished ovarian reserve (DOR) diagnosed by elevated early follicular-phase FSH levels. DESIGN:Retrospective study. SETTING:Academic and academically affiliated assisted reproductive technology...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2011.03.071
更新日期:2011-06-01 00:00:00
abstract:OBJECTIVE:To examine the small antral follicle (SAF) cohort in ovaries of adult rhesus monkeys after consumption of a Western-style diet (WSD), with or without chronically elevated androgen levels since before puberty. DESIGN:Cholesterol or T (n = 6 per group) implants were placed SC in female rhesus macaques beginnin...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2015.11.045
更新日期:2016-04-01 00:00:00
abstract:OBJECTIVE:To evaluate sperm morphology assessment using the IVOS (Hamilton-Thorne Research Version 3 Dimension Program, Beverly, MA) system in prediction of fertilization rate in vitro after intracytoplasmic sperm injection (ICSI). DESIGN:A prospective clinical study. SETTING:Diagnostic andrology laboratory and assis...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(97)00555-4
更新日期:1998-03-01 00:00:00
abstract::This population-based study assessed information needs related to fertility and sexual function in 250 non-Hodgkin's lymphoma survivors from a Los Angeles Surveillance, Epidemiology, and End Results cancer registry 2-5 years after diagnosis. Results suggest that many survivors have persistent fertility and sexual conc...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2007.08.081
更新日期:2008-10-01 00:00:00
abstract::To explore the relationship between variation in AGT M235T gene and the development of the polycystic ovary syndrome (PCOS) and its sequelae, in the present study we evaluated AGT polymorphism M235T in women with PCOS and in a control group. Moreover, to detect any relationship between AGT M235T variation and intermed...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2005.05.043
更新日期:2005-11-01 00:00:00
abstract:OBJECTIVE:To evaluate the effectiveness of hysteroscopic selective salpingography (HSS) as a method for diagnosing the tubal proximal occlusion shown by hysterosalpingography (HSG). DESIGN:Prospective study. SETTING:Outpatient Department of Obstetrics and Gynecology, Social Insurance Saitama Chuo Hospital, Urawa, Jap...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(99)00324-6
更新日期:1999-10-01 00:00:00
abstract:OBJECTIVE:To review the mechanisms of T replacement therapy's inhibition of spermatogenesis and current therapeutic approaches in reproductive aged men. DESIGN:Review of published literature. SETTING:PubMed search from 1990-2012. PATIENT(S):PubMed search from 1990-2012. INTERVENTION(S):A literature review was perfo...
journal_title:Fertility and sterility
pub_type: 杂志文章,评审
doi:10.1016/j.fertnstert.2012.10.052
更新日期:2013-03-01 00:00:00
abstract::Tissue integrity of the regurgitated endometrium is pivotal to the development of endometriosis. Occult, submicroscopic lesions occur. Diagnostic laparoscopy may underestimate as well as overestimate the presence of endometriosis. ...
journal_title:Fertility and sterility
pub_type: 评论,杂志文章,评审
doi:10.1016/j.fertnstert.2005.01.122
更新日期:2005-07-01 00:00:00
abstract:OBJECTIVE:To evaluate whether endometrioma is associated with a progressive decline in ovarian reserve, and to compare the rate of decline with natural decline in ovarian reserve. DESIGN:Prospective, observational study. SETTING:Tertiary university hospital, endometriosis clinic. PATIENT(S):Forty women with endometr...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2018.03.015
更新日期:2018-07-01 00:00:00
abstract::We describe a cotyledonoid dissecting leiomyoma in a 33-year-old nulliparous woman treated by laparoscopy. ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2008.08.131
更新日期:2009-04-01 00:00:00
abstract::This study was initiated to determine whether factors are present in human sperm-free seminal plasma (HSP) that regulate the uptake and release of carnitine from sperm. Bovine caput epididymal sperm cells accumulated more carnitine than caudal sperm cells. A significant reduction in carnitine uptake by caput sperm was...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:
更新日期:1988-05-01 00:00:00
abstract:OBJECTIVE:To evaluate follicular FSH and LH requirements during suppression of endogenous gonadotropins with the GnRH antagonist Nal-Glu and whether LH-like activity could be supplied by administering subcutaneous hCG. DESIGN:Randomized clinical trial. PARTICIPANTS:Thirty-two normally cycling females in the late foll...
journal_title:Fertility and sterility
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1995-02-01 00:00:00
abstract::Since the advent of preimplantation genetic testing for aneuploidy (PGT-A) in the 1990s, substantial changes in test methodology and technology now allow the detection and reporting of intermediate chromosome copy number (commonly referred to as mosaicism) for aneuploidy in a trophectoderm biopsy sample. Clinicians ar...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2020.05.014
更新日期:2020-08-01 00:00:00
abstract::This study describes maternal and birth outcomes of primiparae aged ≥ 45. High rates of pregnancy complications and poor birth outcomes were found, stressing that the personal risks and ramifications to the health system should be taken into account in establishing obstetric health policy regarding primiparity at adva...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2011.02.031
更新日期:2011-06-30 00:00:00
abstract:OBJECTIVE:To investigate differentially expressed genes in epithelial and stromal cells of eutopic endometrium from patients with deep endometriosis and women with normal pelvic cavities using laser capture microdissection and complementary DNA microarrays. DESIGN:Prospective study. SETTING:University hospital. PATI...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2005.04.041
更新日期:2005-10-01 00:00:00
abstract:OBJECTIVE:To investigate whether interleukin-1beta (IL-1beta) and interleukin-1alpha (IL-1alpha) affect the implantation rate of patients undergoing IVF-ET. DESIGN:Follicular fluid and serum were obtained on the day of hCG administration, the day of oocyte retrieval, and the day of embryo transfer. SETTING:Cellular i...
journal_title:Fertility and sterility
pub_type: 临床试验,杂志文章
doi:10.1016/s0015-0282(98)00243-x
更新日期:1998-09-01 00:00:00
abstract:OBJECTIVE:To evaluate the expression pattern of Dazl (deleted in azoospermia-like) protein in the mouse preimplantation embryo. DESIGN:Experimental study. SETTING:Medical research laboratory in a university hospital. ANIMAL(S):Twenty female 28- to 35-day-old FVB mice. INTERVENTION(S):Embryo collection at 1.5, 2.5, ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2007.03.041
更新日期:2008-05-01 00:00:00
abstract:OBJECTIVE:To develop the Cognitive Appraisal Scale for Infertility (CASI) and assess it for reliability and validity. DESIGN:Cross-sectional and longitudinal study. SETTING:A private fertility institute in Japan. PATIENT(S):223 infertile women being treated at the institute. INTERVENTION(S):Administration of questi...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2008.03.052
更新日期:2009-06-01 00:00:00
abstract:OBJECTIVE:To examine the effects of different thermodynamic control systems on the temperature stability of human eggs during in vitro manipulation, with the integrity of meiotic spindles imaged using the LC-PolScope (Cambridge Research & Instrumentation, Inc., Woburn, MA). DESIGN:We performed intracytoplasmic sperm i...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(02)03117-5
更新日期:2002-06-01 00:00:00
abstract:STUDY OBJECTIVE:To determine the extent to which increasing doses of exogenous testosterone (T) administered via Silastic implants can restore spermatogenesis and fertility to rats made azoospermic by active immunization against gonadotropin-releasing hormone (GnRH). DESIGN:Male rats were made azoospermic by active im...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)55192-9
更新日期:1992-08-01 00:00:00
abstract:OBJECTIVE:To describe the use of Essure microinsert placement in patients with hydrosalpinges before IVF. DESIGN:Retrospective case-series. SETTING:An advanced endoscopic practice within a university-affiliated teaching hospital. PATIENT(S):Five women with unilateral or bilateral hydrosalpinges on transvaginal ultra...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2007.01.050
更新日期:2007-12-01 00:00:00
abstract:OBJECTIVE:To review the definition and diagnosis of interstitial and heterotopic interstitial pregnancy and to evaluate the conservative management of these conditions. DESIGN:A MEDLINE computer search was used to identify relevant studies. The mean values for the duration of amenorrhea, serum beta-hCG level, size of ...
journal_title:Fertility and sterility
pub_type: 杂志文章,评审
doi:10.1016/s0015-0282(99)00242-3
更新日期:1999-08-01 00:00:00
abstract::Sixty infertile women underwent infertility surgery followed by "second-look laparoscopy" (SLL). All these women had undergone detailed fertility workups, including a diagnostic laparoscopy prior to surgery. The tuboovarian adhesive disease was staged according to the severity of the disease and compared with findings...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:
更新日期:1982-09-01 00:00:00
abstract:OBJECTIVE:To examine total ezrin expression (ezrin and phospho-ezrin) through the normal endometrial cycle and to correlate ezrin activation and localization with cytologic changes. DESIGN:Experimental laboratory study. SETTING:University medical centers. PATIENT(S):Reproductive-age women. INTERVENTION(S):A total o...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2011.10.039
更新日期:2012-01-01 00:00:00
abstract::The hyperandrogenic-insulin-resistant acanthosis nigricans syndrome affects between 2% and 5% of hirsute women and is characterized by INS resistance, elevated INS levels, acanthosis nigricans, and androgen excess. These patients' response to therapy is unclear, although long-acting GnRH-a suppression has been propose...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:
更新日期:1994-03-01 00:00:00
abstract::A prospective randomized study was conducted in 100 women with leiomyomas in order to evaluate the effect of gestrinone, a synthetic derivative of ethynil-nor-testosterone. Patients in group A received capsules containing 2.5 mg of gestrinone three times weekly orally. Those in group B received capsules containing 5.0...
journal_title:Fertility and sterility
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0015-0282(16)60722-7
更新日期:1989-06-01 00:00:00
abstract:OBJECTIVE:To investigate the ability of GH to increase the steroidogenic response of the ovary to FSH in the early stage of human follicle development in vivo. DESIGN:Ovarian sensitivity to FSH and/or GH during the early follicular phase of the human menstrual cycle was evaluated in a prospective study. SETTING:Norma...
journal_title:Fertility and sterility
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0015-0282(16)58688-9
更新日期:1996-12-01 00:00:00
abstract::After initial videolaseroscopy for the treatment of endometriosis-associated infertility, 157 patients underwent a second-look laparoscopy to evaluate and treat recurrence of disease and/or adhesions. The patients were divided into two groups. Group 1 consisted of 135 patients who underwent second-look laparoscopy for...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)53576-6
更新日期:1990-06-01 00:00:00