Random anti-Müllerian hormone (AMH) is a predictor of ovarian response in women with elevated baseline early follicular follicle-stimulating hormone levels.

Abstract:

OBJECTIVE:To investigate the utility of random anti-Müllerian hormone (AMH) in assessing ovarian response among women with diminished ovarian reserve (DOR) diagnosed by elevated early follicular-phase FSH levels. DESIGN:Retrospective study. SETTING:Academic and academically affiliated assisted reproductive technology (ART) programs. PATIENT(S):Seventy-three women undergoing ART with elevated early follicular FSH levels. INTERVENTION(S):None. MAIN OUTCOME MEASURE(S):Number of oocytes retrieved during ART cycle, number of day 3 embryos, and cycle cancellation and clinical pregnancy rates. RESULT(S):Random AMH levels were strongly correlated with the number of oocytes retrieved during an ART cycle among women with elevated FSH (r=0.55). Women with elevated FSH who had a random serum AMH level of 0.6 ng/mL or higher had twice the number of oocytes retrieved (11±1.3 vs. 5.6±0.6), a greater number of day 3 embryos (5.7±0.9 vs. 3±0.5), and approximately a third of the cycle cancellation rate (14% vs. 41%) compared with women with a random serum AMH below 0.6 ng/mL. The clinical pregnancy rate was also higher among women with a random serum AMH≥0.6 ng/mL (28% vs. 14%), however, the difference was not statistically significant. CONCLUSION(S):A random serum AMH level is useful in setting expectations for ART prognosis in women with elevated early follicular-phase serum FSH levels.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Buyuk E,Seifer DB,Younger J,Grazi RV,Lieman H

doi

10.1016/j.fertnstert.2011.03.071

subject

Has Abstract

pub_date

2011-06-01 00:00:00

pages

2369-72

issue

7

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(11)00501-2

journal_volume

95

pub_type

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