Abstract：
OBJECTIVE:To evaluate the effects of a prolonged duration of gonadotropin-releasing hormone agonist (GnRH-a) in pituitary down-regulation for controlled ovarian hyperstimulation (COH) on the live-birth rate in nonendometriotic women undergoing in vitro fertilization and embryo transfer (IVF-ET). DESIGN:Retrospective cohort study. SETTING:University-affiliated hospital. PATIENT(S):Normogonadotropic women undergoing IVF. INTERVENTION(S):Three hundred seventy-eight patients receiving a prolonged pituitary down-regulation with GnRH-a before ovarian stimulation and 422 patients receiving a GnRH-a long protocol. MAIN OUTCOME MEASURE(S):Live-birth rate per fresh ET. RESULT(S):In comparison with the long protocol, the prolonged down-regulation protocol required a higher total dose of gonadotropins. A lower serum luteinizing hormone (LH) level on the starting day of gonadotropin and the day of human chorionic gonadotropin (hCG) and a fewer number of oocytes and embryos were observed in the prolonged down-regulation protocol. However, the duration of stimulation and number of high-quality embryos were comparable between the two groups. A statistically significantly higher implantation rate (50.27% vs. 39.69%), clinical pregnancy rate (64.02% vs. 56.87%) and live-birth rate per fresh transfer cycle (55.56% vs. 45.73%) were observed in the prolonged protocol. CONCLUSION(S):Prolonged down-regulation in a GnRH-a protocol might increase the live-birth rates in normogonadotropic women.
journal_name
Fertil Steriljournal_title
Fertility and sterilityauthors
Ren J,Sha A,Han D,Li P,Geng J,Ma Cdoi
10.1016/j.fertnstert.2014.03.030subject
Has Abstractpub_date
2014-07-01 00:00:00pages
75-81issue
1eissn
0015-0282issn
1556-5653pii
S0015-0282(14)00271-4journal_volume
102pub_type
杂志文章abstract：OBJECTIVE:To assess the effects of estro-progestin supplementation on ghrelin-mediated GH release, we studied the consequence of ghrelin or saline injection before and after 60 days of hormone therapy or placebo administration in postmenopausal subjects. DESIGN:A prospective double blind, placebo-controlled, and paral...
journal_title：Fertility and sterility
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.fertnstert.2007.02.042
更新日期：2008-02-01 00:00:00
abstract：:The association between educational level and cycle outcomes was quantified by applying multivariable logistic and linear regression within a prospective cohort of 2,569 women commencing their first in vitro fertilization (IVF) cycle. Although a woman's educational attainment was not associated with the likelihood of ...
journal_title：Fertility and sterility
pub_type： 杂志文章,多中心研究
doi：10.1016/j.fertnstert.2011.05.015
更新日期：2011-06-30 00:00:00
abstract：OBJECTIVE:To compare the effects of gonadotropin-releasing hormone agonist (GnRH-a) initiation either preceding or concurrent with controlled ovarian hyperstimulation (COH) in patients undergoing in vitro fertilization-embryo transfer (IVF-ET). DESIGN:Fifty-five patients were prospectively randomized to receive either...
journal_title：Fertility and sterility
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0015-0282(16)55322-9
更新日期：1992-10-01 00:00:00
abstract：:A study was undertaken to examine the influence of pH on the migration of X and Y sperm as observed in freshly ejaculated semen samples from human donors. These sperm were allowed to migrate into capillary tubes containing media of varying pH. Y-carrying sperm were i dentified using flourescent staining with quinacr...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)38224-3
更新日期：1971-05-01 00:00:00
abstract：OBJECTIVE:To investigate whether testicular cytology by fine needle aspiration (FNA) may be considered a diagnostic parameter in the evaluation of the azoospermic subject. DESIGN:Cytologic smears were obtained using a 23-G needle, stained with May-Grünwald-Giemsa stain and examined under a light Orthoplan microscope (...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)54971-1
更新日期：1992-04-01 00:00:00
abstract：OBJECTIVE:To investigate the biocompatibility of a novel copper-containing composite to provide preclinical data for clinical application of intrauterine device (IUD) or intra-vas device (IVD). DESIGN:Prospective experimental study. SETTING:Good laboratory practices laboratories. ANIMALS:Twenty healthy adult mice (S...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2010.04.041
更新日期：2011-03-15 00:00:00
abstract：OBJECTIVE:To determine whether preoperative hysteroscopic examination increases the risk for peritoneal dissemination of endometrial cancer cells and the effect of hysteroscopy on disease prognosis. DESIGN:Meta-analysis. SETTING:Literature search conducted via domestic and international databases for studies on preop...
journal_title：Fertility and sterility
pub_type： 杂志文章,meta分析
doi：10.1016/j.fertnstert.2011.07.1146
更新日期：2011-10-01 00:00:00
abstract：OBJECTIVE:Our objective is to report observed changes in thyroid-stimulating hormone (TSH) in two patients undergoing super-ovulation for IVF. DESIGN:Case report. SETTING:Private assisted reproduction practices. PATIENT(S):Two hypothyroid women taking thyroxine replacement therapy undergoing super-ovulation for IVF....
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2009.11.051
更新日期：2010-05-01 00:00:00
abstract：OBJECTIVE:To assess the relative efficacy, in terms of clinical pregnancy rates (PRs), of transuterotubal insemination versus the more traditional intrauterine insemination (IUI) procedure. DESIGN:Prospective, randomized, cross-over. SETTING:University-affiliated tertiary care center. PATIENTS:One hundred sixty infe...
journal_title：Fertility and sterility
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1992-07-01 00:00:00
abstract：OBJECTIVE:To study the value of virtual hysterosalpingography (VHSG) in the diagnosis of bicornuate vs. septate uterus. DESIGN:Retrospective study of all cases with bicornuate or septate uterus that had VHSG during the last 3 years at our center. SETTING:Private fertility center and radiology institute with universit...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2011.08.026
更新日期：2011-11-01 00:00:00
abstract：:One hundred and twenty rats were divided into six groups and laparotomized. In three of the groups the cecum was left intact. In one of these groups the cecum was only lifted up through the abdominal incision and then replaced in the abdominal cavity. In another group the intact cecum was bathed with a certain amount ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)43584-3
更新日期：1978-10-01 00:00:00
abstract：:Detection of bacteria with molecular techniques has enabled the study of low biomass microbiomes in tissues and organs previously considered sterile, such as the endometrium. Subsequently, an abnormal endometrial microbiota has been associated with implantation failure, pregnancy loss, and other gynecological and obst...
journal_title：Fertility and sterility
pub_type： 杂志文章,评审
doi：10.1016/j.fertnstert.2017.05.034
更新日期：2017-07-01 00:00:00
abstract：OBJECTIVE:To evaluate the heparin-glutathione test (HEGLUT) for the selection of viable sperm for intracytoplasmic sperm injection (ICSI). DESIGN:A prospective study. SETTING:Department of Pediatrics, Obstetrics and Gynecology, University of Valencia and Instituto Valenciano de Infertilidad. PATIENT(S):Semen samples...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(98)00334-3
更新日期：1998-12-01 00:00:00
abstract：:Combined therapy with clomiphene and intranasal luteinizing hormone-releasing hormone (LHRH) was used to induce ovulation in eight chronically anovulatory patients under treatment for infertility. Clomiphene, 100 mg daily, was given from the 5th to the 9th day of the cycle. Synthetic LHRH was administered intranasally...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：
更新日期：1980-11-01 00:00:00
abstract：:The rapid postpartum return of gonadotropic function during bromocriptine treatment was investigated through hormonal measurements in 15 women. Luteinizing hormone (LH) was measured by a novel and specific assay that does not cross-react with human chorionic gonadotropin (hCG). Prolactin was effectively suppressed by ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)60610-6
更新日期：1989-04-01 00:00:00
abstract：:A case of intramural but not interstitial pregnancy, established after IVF/ET, is described. The etiologic, diagnostic, and therapeutic aspects of this clinical dilemma are discussed. ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)54804-3
更新日期：1992-01-01 00:00:00
abstract：OBJECTIVE:To determine whether cytokines implicated in uterine receptivity are detectable in cervicovaginal secretions and/or serum of fertile women, and whether their concentrations undergo hormonal regulation during the menstrual cycle. DESIGN:Prospective, observational study. SETTING:Academic medical center. PATI...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2004.03.039
更新日期：2004-10-01 00:00:00
abstract：:Five patients with primary infertility and secondary amenorrhea who did not respond to clomiphene with a gonadotropin or estrogen surge were treated with 500 mug of luteinizing hormone, follicle-stimulating hormone-releasing hormone (LH-RH), self-administered subcutaneously every 8 hours for 14 days. Of four patients ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)41890-x
更新日期：1976-06-01 00:00:00
abstract：OBJECTIVE:To investigate the effects of thawing temperature on sperm function after cryopreservation. The technical aspects of sperm cryopreservation have significantly improved over the last few decades. However, a standard protocol designed to optimize sperm motility recovery after thawing has not yet been establishe...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2008.10.021
更新日期：2010-02-01 00:00:00
abstract：:Selective uterine devascularization before myomectomy at the time of cesarean section is a novel technique that facilitates myomectomy and is a safe procedure avoiding the need for subsequent surgery. ...
journal_title：Fertility and sterility
pub_type： 信件
doi：10.1016/j.fertnstert.2009.09.027
更新日期：2010-06-01 00:00:00
abstract：:The role of the macromolecular constituents of human oviductal fluid (hOF) in reproductive physiology is poorly understood. Oviductal fluid contains proteins derived by transudation from serum and those synthesized and secreted by the tubal mucosa. In this communication, we describe purification of hOF-specific protei...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)60433-8
更新日期：1989-01-01 00:00:00
abstract：:Two models of levonorgestrel-releasing intrauterine devices were studied. Model A was designed to deliver 20 micrograms/day, and model B was designed to deliver 30 micrograms/day. Plasma concentrations of levonorgestrel were determined in blood samples taken from women who used the levonorgestrel-releasing intrauterin...
journal_title：Fertility and sterility
pub_type： 临床试验,杂志文章
doi：10.1016/s0015-0282(16)49397-0
更新日期：1986-06-01 00:00:00
abstract：OBJECTIVE:To study the chromosomal content of spermatozoa selected by intracytoplasmic morphologically selected sperm injection (IMSI) in cases of macrocephalic sperm head syndrome. DESIGN:Case report. SETTING:Obstetrics, gynecology, urology, and reproductive biology departments. PATIENT(S):Two infertile patients wi...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2008.10.059
更新日期：2010-03-01 00:00:00
abstract：OBJECTIVE:To evaluate the efficacy of a dry versus humidified incubator on human embryo development ex vivo. DESIGN:Prospective, double-blind, randomized, controlled trial. SETTING:Private fertility centers. PATIENT(S):A total of 297 women undergoing in vitro fertilization randomized into two groups. INTERVENTION(S...
journal_title：Fertility and sterility
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.fertnstert.2017.05.036
更新日期：2017-08-01 00:00:00
abstract：OBJECTIVE:To study birth outcomes among live born infants conceived by women who used infertility treatment. DESIGN:Population-based surveillance of women who recently delivered a live infant. SETTING:The birth outcomes among infants whose mothers used assisted reproductive technology (ART) or ovulation stimulation m...
journal_title：Fertility and sterility
pub_type： 杂志文章,多中心研究
doi：10.1016/j.fertnstert.2011.05.073
更新日期：2011-08-01 00:00:00
abstract：OBJECTIVE:To determine Müllerian inhibiting substance (MIS) levels in follicular fluid (FF) and sera of IVF patients. DESIGN:Prospective study. SETTING:Fertility center. PATIENT(S):Sixty-six patients: 20 with tubal factor infertility, 17 with polycystic ovary syndrome (PCOS), and 29 with endometriosis. INTERVENTION...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(97)81417-3
更新日期：1997-05-01 00:00:00
abstract：:Nonaromatizable androgens, administered in high doses to an adult patient with partial androgen insensitivity, failed to result in a change in phallic size despite a clear decline in SHBG and gonadotropin levels. These findings raise the question of differential tissue sensitivity to androgens. Because ancillary labor...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)56114-7
更新日期：1993-08-01 00:00:00
abstract：OBJECTIVE:To study the effects of peritoneal macrophages on endometrial cellular proliferation in an in vitro coculture model and to compare the magnitude of these effects between macrophages from women with endometriosis and normal women. DESIGN:Controlled study of peritoneal macrophage function. SETTING:University ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(99)00292-7
更新日期：1999-09-01 00:00:00
abstract：:In the present study, we investigated the impact of metformin therapy on in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) outcomes in patients with polycystic ovary syndrome (PCOS). Metformin does not lead to any improvement in IVF/ICSI outcomes among patients with PCOS. ...
journal_title：Fertility and sterility
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.fertnstert.2005.03.043
更新日期：2005-09-01 00:00:00
abstract：:To assess the risk of introducing microorganisms into the peritoneal cavity during intracervical or intrauterine insemination, we cultured the cervix and semen from 19 couples before insemination and the peritoneal fluid from the female partner after insemination. The peritoneal cultures taken before hydrotubation gre...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)49458-6
更新日期：1986-07-01 00:00:00
