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Can intracytoplasmic morphologically selected sperm injection be used to select normal-sized sperm heads in infertile patients with macrocephalic sperm head syndrome?

Abstract：

OBJECTIVE:To study the chromosomal content of spermatozoa selected by intracytoplasmic morphologically selected sperm injection (IMSI) in cases of macrocephalic sperm head syndrome. DESIGN:Case report. SETTING:Obstetrics, gynecology, urology, and reproductive biology departments. PATIENT(S):Two infertile patients with large-headed spermatozoa. INTERVENTION(S):Fluorescence in situ hybridization on selected spermatozoa with normal-sized heads after IMSI selection. MAIN OUTCOME MEASURE(S):Percentages of polyploid, diploid, haploid aneuploid, and normal spermatozoa. RESULT(S):Of the six spermatozoa that could be selected, all were haploid but aneuploid. CONCLUSION(S):Absence of normal haploid spermatozoa among high magnification-selected spermatozoa contraindicated IMSI for these two patients.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Chelli MH,Albert M,Ray PF,Guthauser B,Izard V,Hammoud I,Selva J,Vialard F

doi

10.1016/j.fertnstert.2008.10.059

subject

Has Abstract

pub_date

2010-03-01 00:00:00

pages

1347.e1-5

issue

4

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(08)04422-1

journal_volume

93

pub_type

杂志文章

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