Role of blood and fibrinogen in development of intraperitoneal adhesions in rats.


:One hundred and twenty rats were divided into six groups and laparotomized. In three of the groups the cecum was left intact. In one of these groups the cecum was only lifted up through the abdominal incision and then replaced in the abdominal cavity. In another group the intact cecum was bathed with a certain amount of blood from the animal's tail. In the third group the uninjured cecum was covered with fibrinogen in an amount equivalent to that in the blood used in the other group. In the remaining three groups the cecum was traumatized in a standardized way. In one of these groups the injured cecum was left untreated. In another group the traumatized cecum was bathed in homologous blood and in the third group the injured cecum was treated with fibrinogen as described above. Two weeks later the rats were killed and the number and quality of the intra-abdominal adhesions were studied. The findings in the present investigation indicate that neither blood nor fibrinogen per se induced adhesions to the serosa. On the contrary, a defect in the serosa initiated the formation of adhesions.


Fertil Steril


Fertility and sterility


Nisell H,Larsson B




Has Abstract


1978-10-01 00:00:00














  • Embryo implantation in in vitro fertilization and intracytoplasmic sperm injection: impact of cleavage status, morphology grade, and number of embryos transferred.

    abstract:OBJECTIVE:The aims of this study were to compare preimplantation embryo quality in intracytoplasmic sperm injection (ICSI) with standard IVF and to examine the impact of age and number and quality of embryos transferred on implantation and pregnancy. DESIGN:Retrospective, controlled clinical study. SETTING:Academic t...

    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章


    authors: Hsu MI,Mayer J,Aronshon M,Lanzendorf S,Muasher S,Kolm P,Oehninger S

    更新日期:1999-10-01 00:00:00

  • Sperm morphology evaluated by computer (IVOS) cannot predict the fertilization rate in vitro after intracytoplasmic sperm injection.

    abstract:OBJECTIVE:To evaluate sperm morphology assessment using the IVOS (Hamilton-Thorne Research Version 3 Dimension Program, Beverly, MA) system in prediction of fertilization rate in vitro after intracytoplasmic sperm injection (ICSI). DESIGN:A prospective clinical study. SETTING:Diagnostic andrology laboratory and assis...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Sukcharoen N,Sithipravej T,Promviengchai S,Chinpilas V,Boonkasemsanti W

    更新日期:1998-03-01 00:00:00

  • Antioxidants in fertility: impact on male and female reproductive outcomes.

    abstract::A couple may be considered to have fertility problems if they have been trying to conceive for over 1 year with no success. Worldwide, the inability to have children affects 10% to 15% of all couples. Subfertility can be divided into either male or female factor, or both partners can be affected. However, for some cou...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,评审


    authors: Smits RM,Mackenzie-Proctor R,Fleischer K,Showell MG

    更新日期:2018-09-01 00:00:00

  • Chemokine CCL2 enhances survival and invasiveness of endometrial stromal cells in an autocrine manner by activating Akt and MAPK/Erk1/2 signal pathway.

    abstract:OBJECTIVE:To clarify the role and mechanism of CCL2 in regulating the biological functions of endometrial stromal cells (ESCs). DESIGN:The CCL2 effect on the viability, proliferation, and invasion in the eutopic ESCs from endometriosis. SETTING:Research laboratories. PATIENT(S):Patients with endometriosis aged 23-47...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Li MQ,Li HP,Meng YH,Wang XQ,Zhu XY,Mei J,Li DJ

    更新日期:2012-04-01 00:00:00

  • The route of administration influences the effect of estrogen on insulin sensitivity in postmenopausal women.

    abstract:OBJECTIVE:To determine the effect of transdermal estrogen on insulin sensitivity in postmenopausal women and to compare this effect with changes observed with oral conjugated equine estrogens. DESIGN:Fourteen postmenopausal women were randomized to receive a transdermal E2 patch, 0.1 mg, for 25 days each month (n = 7)...

    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Lindheim SR,Duffy DM,Kojima T,Vijod MA,Stanczyk FZ,Lobo RA

    更新日期:1994-12-01 00:00:00

  • Improvement of post-thaw sperm motility in poor quality human semen.

    abstract:OBJECTIVE:To find alternative cryopreservation methods to improve the post-thaw fertilizing capacity of poor quality human sperm. DESIGN:Controlled clinical study. SETTING:Fertility clinic of a teaching hospital. PATIENTS:Men with poor quality semen samples, i.e., asthenozoospermia (< 40% motile sperm) and/or oligoz...

    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章


    authors: Sawetawan C,Bruns ES,Prins GS

    更新日期:1993-10-01 00:00:00

  • Seminal fluid and fertility in women.

    abstract::Seminal fluid is often viewed as simply a vehicle to carry sperm to fertilize the oocyte, but a more complex function in influencing female reproductive physiology is now evident. Remarkably, seminal fluid contains soluble and exosome-born signaling agents that interact with the female reproductive tract to prime the ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,评审


    authors: Robertson SA,Sharkey DJ

    更新日期:2016-09-01 00:00:00

  • Development of a method to isolate and culture highly purified populations of stromal and epithelial cells from human endometrial biopsy specimens.

    abstract::Appropriate endometrial maturation is of paramount importance to achieve reproductive success. Practical and ethical considerations require that in vitro methods be available to evaluate regulation of human endometrial function. Additionally, tissue complexity requires separation of individual cell populations. This r...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Osteen KG,Hill GA,Hargrove JT,Gorstein F

    更新日期:1989-12-01 00:00:00

  • Endometriosis entrapment of the obturator nerve after previous cervical cancer surgery.

    abstract::A 26-year-old patient underwent pelvic lymphadenectomy and trachelectomy because of cervical cancer stage IB. Later she developed symptoms from obturator nerve entrapment. Examinations could not reveal metastatic cancer disease, but endometriosis surrounding the obturator nerve was discovered. Laparoscopic removal of ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Langebrekke A,Qvigstad E

    更新日期:2009-02-01 00:00:00

  • Medroxyprogesterone acetate is an effective oral alternative for preventing premature luteinizing hormone surges in women undergoing controlled ovarian hyperstimulation for in vitro fertilization.

    abstract:OBJECTIVE:To investigate the use of medroxyprogesterone acetate (MPA) to prevent LH surge during controlled ovarian hyperstimulation (COH) and to compare cycle characteristics and pregnancy outcomes in subsequently frozen-thawed ET (FET) cycles. DESIGN:A prospective controlled study. SETTING:Tertiary-care academic me...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Kuang Y,Chen Q,Fu Y,Wang Y,Hong Q,Lyu Q,Ai A,Shoham Z

    更新日期:2015-07-01 00:00:00

  • Reconstruction of the ovary containing large endometriomas by an extraovarian endosurgical technique.

    abstract:OBJECTIVE:To describe and evaluate the surgical treatment of large ovarian endometriomas by an extraovarian endosurgical technique. DESIGN:Prospective case series study. SETTING:University center and tertiary referral center for endoscopic surgery. PATIENTS:Patients with large ovarian endometriomas. INTERVENTION:A ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Brosens IA,Van Ballaer P,Puttemans P,Deprest J

    更新日期:1996-10-01 00:00:00

  • Cytokine gene polymorphisms in northern Indian women with recurrent miscarriages.

    abstract:OBJECTIVE:To determine association of cytokine gene polymorphism with risk for recurrent miscarriages (RM). DESIGN:Retrospective case-control study on northern Indian RM cases versus control subjects. SETTING:Medical facility. PATIENT(S):A total of 200 women with at least three unexplained spontaneous abortions befo...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Parveen F,Shukla A,Agarwal S

    更新日期:2013-02-01 00:00:00

  • Endometrial integrin expression in women with recurrent implantation failure after in vitro fertilization and its relationship to pregnancy outcome.

    abstract:OBJECTIVE:To determine expression of integrins α₁, α₄, and αVβ₃ in the glandular and luminal epithelium, stroma, and cells in the blood vessel walls of the endometrium from women with recurrent implantation failure (RIF) and to determine if they are of prognostic value in determining pregnancy outcome. DESIGN:Prospect...

    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章


    authors: Coughlan C,Sinagra M,Ledger W,Li TC,Laird S

    更新日期:2013-09-01 00:00:00

  • Improved single-cell protocol for preimplantation genetic diagnosis of spinal muscular atrophy.

    abstract:OBJECTIVE:To develop and validate a simple and reliable single-cell analysis protocol for the preimplantation genetic diagnosis (PGD) of spinal muscular atrophy (SMA). DESIGN:Molecular tests based on specific enzymatic digestion have already been described for SMA diagnosis. We modified the amplified DNA fragments so ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Burlet P,Frydman N,Gigarel N,Bonnefont JP,Kerbrat V,Tachdjian G,Frydman R,Munnich A,Steffann J,Ray PF

    更新日期:2005-09-01 00:00:00

  • Uterine rupture at the 29th week of subsequent pregnancy after hysteroscopic resection of uterine septum.

    abstract:OBJECTIVE:To describe a patient with uterine rupture in the subsequent pregnancy after hysteroscopic resection of a uterine septum. DESIGN:Case report. SETTING:University hospital. PATIENT(S):A 30-year-old nulliparous woman, with a history of a first trimester spontaneous abortion, hysteroscopic uterine septum resec...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Satiroğlu MH,Gözüküçük M,Cetinkaya SE,Aydinuraz B,Kahraman K

    更新日期:2009-03-01 00:00:00

  • Immunolocalization of angiopoietin 1 in human peritoneal endometriotic lesions.

    abstract:OBJECTIVE:To analyze the expression of angiopoietin 1 (ANGPT1) in pigmented and nonpigmented endometriosis implants and specify its role in the interaction of angiogenic factors. DESIGN:Experimental retrospective study. SETTING:University hospital. PATIENT(S):Eighty-two sections from 201 laparoscopic tissue samples ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Gescher DM,Berndorff U,Meyhoefer-Malik A,Moubayed P,Malik E

    更新日期:2004-03-01 00:00:00

  • Disruption of protein phosphatase 1 complexes with the use of bioportides as a novel approach to target sperm motility.

    abstract:OBJECTIVE:To design protein phosphatase 1 (PP1)-disrupting peptides covalently coupled to inert cell-penetrating peptides (CPPs) as sychnologically organized bioportide constructs as a strategy to modulate sperm motility. DESIGN:Experimental study. SETTING:Academic research laboratory. PATIENT(S)/ANIMAL(S):Normozoos...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Silva JV,Freitas MJ,Santiago J,Jones S,Guimarães S,Vijayaraghavan S,Publicover S,Colombo G,Howl J,Fardilha M

    更新日期:2020-09-22 00:00:00

  • Leyomiomatosis peritonealis disseminata associated with ovarian endometriosis in a patient submitted to hysteroscopic myomectomy.

    abstract:OBJECTIVE:To describe laparoscopic management of a case of leyomiomatosis peritonealis disseminata associated with ovarian endometriosis. DESIGN:Surgical video article. SETTING:Academic hospital. PATIENT:We present a case of a 30-year-old woman referred to our clinic for abdominal and pelvic pain and dyspareunia. A ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Mabrouk M,Arena A,Raimondo D,Parisotto M,Caprara G,Seracchioli R

    更新日期:2019-06-01 00:00:00

  • Genotype and haplotype determination of interleukin (IL) 1 beta (g. -511C>T and g. +3954C>T) and IL-1RN in polycystic ovary syndrome.

    abstract::The distribution of genotype frequencies, allele frequencies, and haplotype frequencies of variable number of tandem repeats (VNTR) in interleukin (IL) 1RN and IL-1beta (-511C > T, exon-5C.>T) polymorphism demonstrated a positive association with the occurrence of polycystic ovary syndrome (PCOS). The carriage of alle...

    journal_title:Fertility and sterility

    pub_type: 信件


    authors: Yang Y,Qiao J,Tang RX,Li MZ

    更新日期:2010-06-01 00:00:00

  • Endometrial antigens involved in the autoimmunity of endometriosis.

    abstract::Serum and peritoneal fluid from five fertile women without endometriosis and serum (n = 23) and peritoneal fluid (n = 12) from infertile women with endometriosis were tested for the presence of antibodies against endometrial tissue antigens by a Western blot analysis. Antigens with molecular weights (MW) of 19, 31, 38...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Mathur S,Chihal HJ,Homm RJ,Garza DE,Rust PF,Williamson HO

    更新日期:1988-12-01 00:00:00

  • Declining estimates of infertility in the United States: 1982-2002.

    abstract:OBJECTIVE:To determine if the decline in infertility has been uniform across subgroups. DESIGN:Periodic data from the National Fertility Survey and the National Survey of Family Growth were used to determine which factors contributed to the decline in 12-month infertility in the United States. SETTING:National Survey...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Stephen EH,Chandra A

    更新日期:2006-09-01 00:00:00

  • Prospective randomized double-blind trial of 3 versus 6 months of nafarelin therapy for endometriosis associated pelvic pain.

    abstract:OBJECTIVES:To determine the effectiveness of a 3-month course of nafarelin and, furthermore, to determine the long-term efficacy in patients treated for 3 and 6 months with nafarelin for symptoms associated with endometriosis. DESIGN:Double-blind, prospective, multicenter, clinical trial. SETTING:Fifteen reproductive...

    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Hornstein MD,Yuzpe AA,Burry KA,Heinrichs LR,Buttram VL Jr,Orwoll ES

    更新日期:1995-05-01 00:00:00

  • Expression of the insulin-like growth factor and insulin systems in the luteinizing macaque ovarian follicle.

    abstract:OBJECTIVE:To determine intrafollicular hormone levels and characterize the mRNA expression of the insulin-like growth factor (IGF) receptors, IGF binding proteins (IGFBP), and pregnancy-associated plasma protein-A (PAPP-A) in granulosa cells before and after an ovulatory hCG stimulus. DESIGN:Experimental animal study....

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Brogan RS,Mix S,Puttabyatappa M,VandeVoort CA,Chaffin CL

    更新日期:2010-03-15 00:00:00

  • Inherited mutation of the luteinizing hormone/choriogonadotropin receptor (LHCGR) in empty follicle syndrome.

    abstract:OBJECTIVE:To test by genomic analysis whether empty follicle syndrome (EFS) in a family with two affected sisters has a genetic basis. DESIGN:Whole-exome sequencing in the context of clinical genetics. SETTING:University hospital. PATIENT(S):Two women (36 and 32 years old at the time of the study) with EFS. INTERVE...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Yariz KO,Walsh T,Uzak A,Spiliopoulos M,Duman D,Onalan G,King MC,Tekin M

    更新日期:2011-08-01 00:00:00

  • Current evaluation of amenorrhea.

    abstract::Amenorrhea is the absence or abnormal cessation of the menses. Primary and secondary amenorrhea describe the occurrence of amenorrhea before and after menarche, respectively. ...

    journal_title:Fertility and sterility

    pub_type: 指南,杂志文章,实务指引


    authors: Practice Committee of the American Society for Reproductive Medicine.

    更新日期:2004-07-01 00:00:00

  • Postoperative adhesion formation after ovarian wedge resection with and without ovarian reconstruction in the rabbit.

    abstract::A rabbit model was used to examine adhesion formation after ovarian wedge resection with and without reapproximation of the ovarian cortex. A wedge resection was completed on one ovary with a scalpel, and the ovarian cortex was reapproximated using microsurgical technique. In the contralateral ovary, a wedge resection...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Brumsted JR,Deaton J,Lavigne E,Riddick DH

    更新日期:1990-04-01 00:00:00

  • Complications of medically assisted conception in 3,500 cycles.

    abstract:OBJECTIVE:To investigate the incidence of complications in the use of assisted reproductive technology in the management of infertile couples. DESIGN:Retrospective study. SETTING:The Egyptian IVF & ET Center, Maadi, Cairo, Egypt. PATIENT(S):Two thousand nine hundred twenty-four patients underwent IVF-ET or intracyto...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Serour GI,Aboulghar M,Mansour R,Sattar MA,Amin Y,Aboulghar H

    更新日期:1998-10-01 00:00:00

  • OCT4 gonadal gene expression related to the presence of Y-chromosome sequences in Turner syndrome.

    abstract::To show that in the dysgenetic gonads of 104 Turner syndrome patients no significant difference was found regarding the expression of the genes DAX1, FOG2, GATA4, OCT4, SF1, SRY, TSPY, WT1, and STRA8 compared with controls, except for genes OCT4, SRY, and TSPY in both gonads of a patient whose chromosomal constitution...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Bianco B,Oliveira KC,Guedes AD,Barbosa CP,Lipay MV,Verreschi IT

    更新日期:2010-11-01 00:00:00

  • Adhesion formation from release of dermoid contents in the peritoneal cavity and effect of copious lavage: a prospective, randomized, blinded, controlled study in a rabbit model.

    abstract:OBJECTIVES:To determine, in a rabbit model, whether peritoneal exposure to dermoid cyst material produces inflammation and adhesions above control levels and whether saline lavage reduces the degree of peritoneal reaction. DESIGN:A prospective, randomized, blinded, controlled study of adhesion formation. Thirty New Ze...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Fielder EP,Guzick DS,Guido R,Kanbour-Shakir A,Krasnow JS

    更新日期:1996-04-01 00:00:00

  • Stimulation of endometrium embryo transfer can improve implantation and pregnancy rates for patients undergoing assisted reproductive technology for the first time with a high-grade blastocyst.

    abstract:OBJECTIVE:To evaluate whether stimulation of endometrium embryo transfer (SEET) can improve implantation rate and pregnancy rate (PR) for patients undergoing assisted reproductive technology (ART) for the first time by injecting embryo culture supernatant into the uterus before blastocyst transfer (BT). DESIGN:Randomi...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,随机对照试验


    authors: Goto S,Kadowaki T,Hashimoto H,Kokeguchi S,Shiotani M

    更新日期:2009-10-01 00:00:00