Serum sex hormone-binding globulin levels show too much variability to be used effectively as a screening marker for insulin resistance in women with polycystic ovary syndrome.

Abstract:

OBJECTIVE:To evaluate the relationship between serum sex hormone-binding globulin (SHBG) and parameters of insulin sensitivity in women with polycystic ovary syndrome (PCOS) and controls, and determine the feasibility of using SHBG levels to predict insulin resistance. DESIGN:Evaluation of a prospectively collected database. SETTING:University reproductive center. PATIENT(S):A total of 21 women with PCOS and 17 controls. INTERVENTION(S):Oral glucose tolerance test. MAIN OUTCOME MEASURE(S):Correlations of serum SHBG and parameters of insulin sensitivity. RESULT(S):[1] Among all participants, SHBG levels indicated a correlation between the fasting glucose-to-insulin (GI) ratio and the quantitative insulin sensitivity check index (QUICKI). Participants with PCOS demonstrated significant correlations of SHBG and fasting GI ratio, 1-hour postglucola insulin levels, and random 17-hydroxyprogesterone (17ohP4) levels. Among controls, SHBG and fasting serum glucose and 2-hour postglucola serum glucose levels were associated. [2] Participants with PCOS and lean controls exhibited different glucose and insulin responses to 75 g of glucose at 1 and 2 hours postchallenge, resulting in paradoxically similar GI ratios. CONCLUSION(S):[1] Although certain parameters of insulin status and serum SHBG demonstrated statistically significant correlation coefficients, these relationships are weak and SHBG cannot be used as a predictor of insulin resistance. [2] The post-glucose load GI ratio cannot be used to determine the magnitude of insulin resistance.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Dahan MH,Goldstein J

doi

10.1016/j.fertnstert.2006.02.108

subject

Has Abstract

pub_date

2006-10-01 00:00:00

pages

934-41

issue

4

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(06)01158-7

journal_volume

86

pub_type

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