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Lack of effect of short-term diazoxide administration on luteinizing hormone secretion in women with polycystic ovary syndrome.

Abstract：

OBJECTIVE:To test the hypothesis that an acute reduction in circulating insulin affects LH secretion in women with polycystic ovary syndrome (PCOS). DESIGN:Prospective study in normal and PCOS women. SETTING:General Clinical Research Centers at the University of Virginia, the Medical College of Virginia, and the Massachusetts General Hospital. PATIENT(S):Six normal women and five women with PCOS. INTERVENTION(S):Administration of diazoxide to lower circulating insulin concentrations. MAIN OUTCOME MEASURE(S):Characteristics of LH secretion as appraised by multiparameter deconvolution and estimation of approximate entropy. RESULT(S):Short-term administration of diazoxide had no effect on the secretion of LH in women with PCOS. CONCLUSION(S):Hyperinsulinemia resulting from insulin resistance in women with PCOS may not have a direct effect on gonadotropin secretion.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Evans WS,Taylor AE,Boyd DG,Johnson ML,Matt DW,Jimenez Y,Nestler JE

doi

10.1016/j.fertnstert.2006.11.109

subject

Has Abstract

pub_date

2007-07-01 00:00:00

pages

118-24

issue

1

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(06)04655-3

journal_volume

88

pub_type

杂志文章

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