Abstract：
:Many women now choose to develop their careers before having children. Thus, it is becoming increasingly important to assess a woman's potential for extended fertility and to understand the health consequences of having children at a late age. In particular, there is a striking positive correlation between extended fertility and longevity in women, which poses important implications for medicine, biology, and evolution. In this article we review the diverse epidemiologic evidence for the link between fertility potential, age of menopause, and women's lifespan. Then we discuss the recent advances using genomic technology to better understand biological mechanisms driving this association. At the genetic level, there are polymorphisms that may be driving both extended fertility and longevity. At the cellular and molecular levels, changes in the genome (both nuclear and mitochondrial), epigenome, and transcriptome during oocyte aging have important implications for fertility. By synthesizing results from diverse domains, we hope to provide a genomic-era conceptual framework in which this important connection can be investigated and understood.
journal_name
Fertil Steriljournal_title
Fertility and sterilityauthors
Wainer-Katsir K,Zou JY,Linial Mdoi
10.1016/j.fertnstert.2015.02.008subject
Has Abstractpub_date
2015-05-01 00:00:00pages
1117-24issue
5eissn
0015-0282issn
1556-5653pii
S0015-0282(15)00130-2journal_volume
103pub_type
杂志文章,评审abstract：:In two patients with apparent PTO, as diagnosed by HSG and laparoscopy, tubal patency was restored by hysteroscopic cannulation of the tubal ostia, followed by direct lavage. Tubal resection and reanastomosis/reimplantation may not be necessary for all patients with apparent PTO. ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：
更新日期：1987-09-01 00:00:00
abstract：OBJECTIVE:To determine the aneuploidy rate in embryos of women with idiopathic recurrent miscarriages and to evaluate whether preimplantation genetic diagnosis for aneuploidy screening could be a feasible approach to improve the possibility of successful pregnancy in these couples. DESIGN:Prospective cohort study. SE...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2004.06.071
更新日期：2005-02-01 00:00:00
abstract：OBJECTIVE:To describe the prevalence of antiphospholipid antibodies to both anionic and zwitterionic phospholipids in women with early recurrent pregnancy losses (RPLs). DESIGN:Retrospective data analysis. SETTING:Tokai University Hospital, Kanagawa, Japan. PATIENT(S):One hundred thirty-nine patients with unexplaine...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(99)00119-3
更新日期：1999-06-01 00:00:00
abstract：OBJECTIVE:To investigate whether zona drilling of oocytes, a technique used to locally disrupt the zona pellucida, causes important changes in intracellular pH. DESIGN AND METHODS:In a first set of experiments, intracellular pH was measured during zona drilling of mouse oocytes, using pH-sensitive microelectrodes. In ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)56525-x
更新日期：1994-02-01 00:00:00
abstract：OBJECTIVE:To study the fusiogenic ability of human spermatozoa and oocytes. DESIGN:Retrospective study of 3,027 oocytes included in a program of subzonal insemination (SUZI). SETTING:Assisted fertilization program in an academic research environment. PATIENT(S):Couples with characterized male factor infertility or p...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(97)81445-8
更新日期：1997-06-01 00:00:00
abstract：:Transvaginal follicular aspiration (TVA) with ultrasonically guided needles allows the transfer of in vitro generated embryos to the fallopian tubes (TET), performing only one surgical procedure in the process. Up to now, this approach has been used to treat 16 couples with infertility due to severe male factor. Folli...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)60136-x
更新日期：1988-09-01 00:00:00
abstract：OBJECTIVE:To determine the normative cut-off score that defines hirsutism among Chinese women, and the effect of age, menstrual irregularities, and polycystic ovaries on the same. DESIGN:Cross-sectional, population-based study. SETTING:A multistage systematic cluster random sampling among 16 communities from two rura...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2011.06.040
更新日期：2011-09-01 00:00:00
abstract：OBJECTIVE:To examine the expression of the heat shock protein hsp70-2, and the possible relationship with the pathogenesis of male infertility. DESIGN:Prospective study. SETTING:Reproductive testing laboratory in a university hospital. PATIENT(S):Men undergoing testicular biopsy during an investigation of subfertili...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(01)02892-8
更新日期：2001-12-01 00:00:00
abstract：OBJECTIVE:To compare the pregnancy outcomes in the setting of a single- vs. double-donor sperm intrauterine insemination (IUI) treatment cycle. DESIGN:Retrospective cohort study. SETTING:Large, private assisted reproductive technology practice. PATIENT(S):Donor sperm IUI recipients. INTERVENTION(S):None. MAIN OUTC...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2014.05.018
更新日期：2014-09-01 00:00:00
abstract：OBJECTIVE:To evaluate whether ethnicity is associated with involuntary childlessness and perceived reasons for difficulties in becoming pregnant. DESIGN:Cross-sectional analysis of baseline data from a longitudinal cohort. SETTING:Multiethnic, community-based observational study of US women. PATIENT(S):Women in midl...
journal_title：Fertility and sterility
pub_type： 杂志文章,多中心研究
doi：10.1016/j.fertnstert.2011.08.039
更新日期：2011-11-01 00:00:00
abstract：OBJECTIVE:To study the efficacy of a new P preparation in aqueous solution for subcutaneous injection for inducing the predecidual transformation of the endometrium. DESIGN:Prospective, single-blinded, randomized, parallel pilot trial. SETTING:University-affiliated clinical research center. PATIENT(S):Twenty-five re...
journal_title：Fertility and sterility
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.fertnstert.2013.05.029
更新日期：2013-09-01 00:00:00
abstract：OBJECTIVE:To examine the influence of hormone-related factors on the risk of invasive epithelial ovarian cancer (ovarian cancer). DESIGN:Population-based case-control study using in-person interviews. SETTING:Academic department of preventive medicine. PATIENT(S):Four hundred seventy-seven ovarian cancer patients an...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2004.03.013
更新日期：2004-07-01 00:00:00
abstract：OBJECTIVE:To evaluate the relationship between serum sex hormone-binding globulin (SHBG) and parameters of insulin sensitivity in women with polycystic ovary syndrome (PCOS) and controls, and determine the feasibility of using SHBG levels to predict insulin resistance. DESIGN:Evaluation of a prospectively collected da...
journal_title：Fertility and sterility
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.fertnstert.2006.02.108
更新日期：2006-10-01 00:00:00
abstract：OBJECTIVE:To manipulate the luteal endometrial progression by the use of antiprogestins. DESIGN:Prospective controlled clinical trial. SETTING:The IVF program of the University of Southern California School of Medicine, Los Angeles, California. PATIENT(S):Thirteen oocyte donors and 20 oocyte recipients. INTERVENTIO...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/S0015-0282(97)81918-8
更新日期：1997-02-01 00:00:00
abstract：OBJECTIVE:To study the messenger ribonucleic acid (mRNA) expression of receptors for insulin, insulin-like growth factor I (IGF-I), and insulin-like growth factor II (IGF-II) in human fetal ovaries and uteri at 10, 15, 19, and 22 weeks' gestation. Insulin, IGF-I, and IGF-II are postulated to have paracrine and autocrin...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)55924-x
更新日期：1993-05-01 00:00:00
abstract：OBJECTIVE:To determine plasma adiponectin concentration in women with and without polycystic ovary syndrome (PCOS) and to assess possible correlations of adiponectin to the hormonal and metabolic parameters, including measures of insulin resistance (IR). DESIGN:Case-control study. SETTING:Tertiary-referral university...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2004.11.077
更新日期：2005-06-01 00:00:00
abstract：:Fresh and aged (24 hours after ovulation) human oocytes and recently ovulated mouse oocytes may be activated by exposure to acidified Tyrode's solution. No activation of either type of human oocyte was observed after exposure to hyaluronidase or pronase, but significant numbers of fresh mouse oocytes were activated af...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)53279-8
更新日期：1990-02-01 00:00:00
abstract：:To understand the mechanism of action of danazol, the binding of danazol to multiple classes of intracellular steroid binding proteins was studied in the human uterine endometrium. Danazol bound to endometrial receptors for estrogen, progesterone, and androgen and seemed to bind to endometrial intracellular corticoste...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)47840-4
更新日期：1984-05-01 00:00:00
abstract：:This study, which is concerned with establishing clinically relevant corridors defining normal progesterone (P) levels in saliva, has addressed some of the shortcomings associated with previous equivalent studies (e.g., limited data, inadequately monitored ovulations, inadequately defined subjects). A sensitive, direc...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)60366-7
更新日期：1988-12-01 00:00:00
abstract：:Specimens for chlamydial culture, direct fluorescent antibody (DFA) test, two enzyme immunoassays (EIA) for antigen detection, and serum for chlamydial antibodies were collected from 256 infertile women. Specimens were taken from the tubes during tuboplasty and from the cervix and endometrium during laparoscopy or tub...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：
更新日期：1991-02-01 00:00:00
abstract：:Examination of 12 paired peritoneal ectopic and eutopic endometria for histochemical binding of Dolichos biflorus agglutinin, normally found in the mid-late secretory part of the cycle, showed a failure of lectin binding in 9 of 11 secretory-phase lesions although the eutopic specimens generally stained normally. This...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2008.11.032
更新日期：2009-04-01 00:00:00
abstract：OBJECTIVE:To determine if increases in core body temperature preceding most hot flashes are caused by increased metabolic rate, peripheral vasoconstriction, or central noradrenergic activation. DESIGN:Laboratory physiological study. SETTING:University medical center. PATIENT(S):Fourteen healthy, postmenopausal women...
journal_title：Fertility and sterility
pub_type： 临床试验,杂志文章
doi：10.1016/s0015-0282(98)00137-x
更新日期：1998-08-01 00:00:00
abstract：:In a qualitative interview study of 77 families with stored frozen embryos, we found that while embryo disposition decision making was influenced by individual life circumstances, embryo quantity/quality, personal values, embryo conceptualization, and clinic information, it was a stepwise process that could be represe...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2009.06.027
更新日期：2009-12-01 00:00:00
abstract：OBJECTIVE:To compare the efficiency of hysterosalpingo-contrast-sonography performed with air and saline (Hydro-HyCoSy) with HyCoSy performed with contrast media (SonoVue) and contrast-tuned imaging technology (CnTI-SonoVue-HyCoSy) considering hysterosalpingography (HSG) and laparoscopy (LPS) as reference tests and to ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2008.07.1746
更新日期：2009-09-01 00:00:00
abstract：:The present study was undertaken to investigate not only the effectiveness of bromoergocryptine therapy in 13 women with amenorrhea-galactorrhea and hyperprolactinemia without evidence of organic pathology, but also to assess the value of pretreatment evaluation in predicting the response to therapy. Sella turcica tom...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)42490-8
更新日期：1977-04-01 00:00:00
abstract：OBJECTIVE:To evaluate the possible relationship between total acrosin activity in spermatozoa and fertility potential after fertilization in vitro. DESIGN:Total acrosin activity of spermatozoa was measured in 101 in vitro fertilization (IVF) cases by an observer unaware of fertilization and cleavage results. SETTING:...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：
更新日期：1991-11-01 00:00:00
abstract：OBJECTIVE:To present the set of reasons for and against fertility treatment for a very young patient. DESIGN:An expert opinion based on clinical experience. SETTING:An academic-affiliated fertility clinic situated in East Jerusalem. PATIENT(S):A 16-year-old married teenager with 2 years' duration of infertility due ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2008.02.172
更新日期：2008-11-01 00:00:00
abstract：OBJECTIVE:To evaluate the effect of frozen, compared with fresh, embryo transfer on neonatal and pediatric weight and weight gain trajectory. DESIGN:Retrospective cohort study. SETTING:Academic medical center. PATIENT(S):Women who underwent fresh or frozen embryo transfer at the Mayo Clinic from 2010 to 2014. All in...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2019.05.020
更新日期：2019-10-01 00:00:00
abstract：:Testosterone and 19-nortestosterone derivatives were evaluated in a developmental scheme designed to identify competitive progesterone antagonists having abortifacient activity. Compounds that displayed significant binding to the rabbit uterine progesterone receptor were followed in biologic tests for progestational, ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)44003-3
更新日期：1979-05-01 00:00:00
abstract：:In this prospective case-control study, we determined the role of surface-enhanced laser desorption and ionization time-of-flight mass spectrometry in the detection of histologically proven endometriosis. In the plasma of the group with endometriosis, there were 20 different protein peaks, and the classifier showed a ...
journal_title：Fertility and sterility
pub_type： 信件
doi：10.1016/j.fertnstert.2006.08.095
更新日期：2007-04-01 00:00:00
