Peritoneal ectopic lesions from women with endometriosis show abnormalities in progesterone-dependent glycan expression.

Abstract:

:Examination of 12 paired peritoneal ectopic and eutopic endometria for histochemical binding of Dolichos biflorus agglutinin, normally found in the mid-late secretory part of the cycle, showed a failure of lectin binding in 9 of 11 secretory-phase lesions although the eutopic specimens generally stained normally. This failure of glycan expression in the secretory phase may result from various anomalies, including an inability to respond to progesterone, possibly due to a lack of, or to nonfunctional, progesterone receptors, suggesting that an ectopic environment may produce changes in tissue cell biology and hormonal responsiveness compared with that of eutopic endometrium.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Jones CJ,Nardo LG,Litta P,Fazleabas AT

doi

10.1016/j.fertnstert.2008.11.032

subject

Has Abstract

pub_date

2009-04-01 00:00:00

pages

1608-10

issue

4 Suppl

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(08)04649-9

journal_volume

91

pub_type

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