Abstract：
OBJECTIVE:To present the set of reasons for and against fertility treatment for a very young patient. DESIGN:An expert opinion based on clinical experience. SETTING:An academic-affiliated fertility clinic situated in East Jerusalem. PATIENT(S):A 16-year-old married teenager with 2 years' duration of infertility due to polycystic ovarian syndrome was referred to our infertility center after treatment with six cycles of clomiphene citrate and ovarian drilling. INTERVENTION(S):Counseling of the options of fertility treatments, weight reduction, physical exercise, metformin intake, and an additional gonadotropins-intrauterine insemination cycle with IVF backup. MAIN OUTCOME MEASURE(S):Successful pregnancy while avoiding the risk of ovarian hyperstimulation syndrome. RESULT(S):The patient conceived a single embryo and on the 30th week of gestation suffered premature uterine contractions and gave birth to a 1,330-g preterm male newborn. CONCLUSION(S):Adolescent contraception and unintended pregnancies are prevalent issues in the Western world, whereas adolescent infertility is unheard of. Early age of marriage and conception imposes tremendous dilemma to the society of reproductive endocrinologists. This important cultural issue ought to be debated regarding the age at marriage, the age at first pregnancy, and the treatment of infertility in married "minors" who need treatment. Such a debate is likely to encourage development of formal guidelines for practitioners, which would clearly be beneficial.
journal_name
Fertil Steriljournal_title
Fertility and sterilityauthors
Haimov-Kochman R,Imbar T,Farchat M,Bdolah Y,Hurwitz Adoi
10.1016/j.fertnstert.2008.02.172subject
Has Abstractpub_date
2008-11-01 00:00:00pages
2009.e1-4issue
5eissn
0015-0282issn
1556-5653pii
S0015-0282(08)00559-1journal_volume
90pub_type
杂志文章abstract：OBJECTIVE:To report a case of monochorionic, diamniotic twin pregnancy diagnosed at 6 weeks of pregnancy with three-dimensional (3D) transvaginal sonography and to discuss the use of this diagnostic method in the evaluation of multifetal pregnancy in the first trimester. DESIGN:Case report. SETTING:University-based I...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(99)00132-6
更新日期：1999-06-01 00:00:00
abstract：OBJECTIVE:To report the results of 20 orthotopic retransplantations of cryopreserved ovarian tissue after cancer treatment. DESIGN:Retrospective analysis. SETTING:Tertiary gynecology department. PATIENT(S):Twenty patients with malignant disease: 11 with hematological malignancies (55%), four with breast cancer (20%)...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2014.10.045
更新日期：2015-02-01 00:00:00
abstract：OBJECTIVE:To determine if increases in core body temperature preceding most hot flashes are caused by increased metabolic rate, peripheral vasoconstriction, or central noradrenergic activation. DESIGN:Laboratory physiological study. SETTING:University medical center. PATIENT(S):Fourteen healthy, postmenopausal women...
journal_title：Fertility and sterility
pub_type： 临床试验,杂志文章
doi：10.1016/s0015-0282(98)00137-x
更新日期：1998-08-01 00:00:00
abstract：:Seven nonionic detergents of the Igepal CO series differing in molecular size and including nonoxynol-9 and a representative anionic (SDS) and cationic (Cepacol) detergent were tested as to their relative cytotoxicity. The biologic effects of these detergents on human W1--38 fibroblasts (DNA and glycosaminoglycans syn...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：
更新日期：1980-05-01 00:00:00
abstract：OBJECTIVE:To present and determine the impact of the Mindfulness-Based Program for Infertility (MBPI). DESIGN:Controlled clinical trial. SETTING:University research unit. PATIENT(S):Fifty-five infertile women completed the MBPI, and 37 infertile women were assigned to a control group. INTERVENTION(S):The MBPI inclu...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2013.05.036
更新日期：2013-10-01 00:00:00
abstract：OBJECTIVE:To compare the euploidy outcome in patients that underwent 2 ovarian stimulation cycles with trophectoderm biopsy. DESIGN:Retrospective repeated-measures cohort study. SETTING:University-based fertility center. PATIENT(S):A total of 116 patients, from 2011 through 2013, that underwent 2 ovarian stimulation...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2014.12.126
更新日期：2015-04-01 00:00:00
abstract：OBJECTIVE:To evaluate whether stimulation of endometrium embryo transfer (SEET) can improve implantation rate and pregnancy rate (PR) for patients undergoing assisted reproductive technology (ART) for the first time by injecting embryo culture supernatant into the uterus before blastocyst transfer (BT). DESIGN:Randomi...
journal_title：Fertility and sterility
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.fertnstert.2008.08.076
更新日期：2009-10-01 00:00:00
abstract：OBJECTIVE:To evaluate the safety profile of endometrial ablation performed with a thermal balloon as defined by serosal temperature elevation and depth of injury. DESIGN:Observational study with histopathologic correlation conducted in ex vivo and in vivo phases. SETTING:Academic medical center. PATIENT(S):Twenty pa...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(98)00245-3
更新日期：1998-10-01 00:00:00
abstract：OBJECTIVE:To determine the effect of administering 6 months of oral postmenopausal DHEA therapy on serum DHEA, DHEAS, and T levels and on physiologic endpoints including lipoproteins and insulin-like growth factor-I (IGF-I). DESIGN:Randomized, double-blind, parallel trial. SETTING:Academic referral practice. PATIENT...
journal_title：Fertility and sterility
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0015-0282(98)00121-6
更新日期：1998-07-01 00:00:00
abstract：:Survey results demonstrate that the majority of fertility clinics in California are willing to care for couples affected by human immunodeficiency virus (HIV) if legal restrictions are removed. In response to scientific advances and evolving clinical standards, California reversed the limitations placed on the provisi...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2008.09.013
更新日期：2009-04-01 00:00:00
abstract：OBJECTIVE:To evaluate the association between genetic variants in Ser-Arg (SR) protein-coding genes and the susceptibility of nonobstructive azoospermia (NOA) in Chinese men. DESIGN:Case-control study. SETTING:State Key Laboratory of Reproductive Medicine in Nanjing Medical University conducted the genotyping and exa...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2014.02.033
更新日期：2014-06-01 00:00:00
abstract：OBJECTIVE:To evaluate the association between FSH efficacy and FSHR alleles. DESIGN:Retrospective study. SETTING:University-based fertility unit and a private center for biomedical research. PATIENT(S):One hundred two women with ovarian function who were undergoing controlled ovarian stimulation (COS). Women were ca...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(03)00795-7
更新日期：2003-09-01 00:00:00
abstract：OBJECTIVE:To investigate whether abnormalities in serum concentrations of 1,25-dihydroxyvitamin D [1,25(OH)(2)D], 25-hydroxyvitamin D [25(OH)D], parathyroid hormone (PTH), calcium, and phosphorus were associated with risk of polycystic ovary syndrome (PCOS) and obesity. The possible correlations of the calciotropic hor...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2008.11.031
更新日期：2010-03-01 00:00:00
abstract：:The potential role of Ureaplasma urealyticum in human infertility make it desirable to screen barren couples for this infection. Semen specimens from 96 consecutive patients were evaluated in our clinic. Microbiologic results were correlated with the percentage of coiled and fuzzy tails in seminal cytology. These feat...
journal_title：Fertility and sterility
pub_type： 临床试验,杂志文章
doi：
更新日期：1978-11-01 00:00:00
abstract：OBJECTIVE:To determine whether progestins activate vascular endothelial growth factor (VEGF) gene transcription in endometrial adenocarcinoma cells. DESIGN:In vitro study. SETTING:University reproductive biology laboratories. PATIENT(S):None. INTERVENTION(S):Ishikawa cells were transfected with VEGF promoter-lucife...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(02)04577-6
更新日期：2003-02-01 00:00:00
abstract：:To determine characteristics associated with regretting sterilization that can be determined preoperatively, we analyzed data from the Collaborative Review of Sterilization (CREST), a multicenter, prospective, observational study. Of 5022 women, 2.0% regretted having had a tubal sterilization at 1 year after the proce...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)48746-7
更新日期：1985-08-01 00:00:00
abstract：:Klemetti's birth registry study is put in context of other major studies. Summary advice is offered to practitioners as to what they should tell parents who conceive with assisted reproductive technology. ...
journal_title：Fertility and sterility
pub_type： 评论,信件
doi：10.1016/j.fertnstert.2005.04.067
更新日期：2005-11-01 00:00:00
abstract：OBJECTIVE:To demonstrate the efficacy and safety of follitropin alfa administered with hCG on spermatogenesis in adult male hypogonadotropic hypogonadism (HH) patients. DESIGN:Phase III, multicenter, open-label, noncomparative. SETTING:Seven US medical centers. PATIENT(S):A total of 36 adult males with severe HH. I...
journal_title：Fertility and sterility
pub_type： 杂志文章,多中心研究
doi：10.1016/j.fertnstert.2008.07.1742
更新日期：2009-09-01 00:00:00
abstract：OBJECTIVE:To quantify nerve fibers and mast cells in human ovaries at different functional stages. DESIGN:Retrospective study. SETTING:Research laboratory of the university. SPECIMEN(S): 8 human ovaries in the follicular (cyclic) phase, 7 polycystic ovaries, and postmenopausal ovaries with (n=5) or without (n=7) hype...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(01)01805-2
更新日期：2001-06-01 00:00:00
abstract：OBJECTIVE:To examine differences in inflammation markers in sexually active versus abstinent women and observe changes in inflammation markers across the menstrual cycle. Cycle-related immune fluctuations may have evolved to reduce interference with conception. If so, reproductively active (i.e., sexually active) women...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2016.11.010
更新日期：2017-03-01 00:00:00
abstract：:Accurate localization of the source of androgen hypersecretion is critical to the appropriate surgical or medical management of women with virilization. Seven patients with virilization and hyperandrogenism of various causes were evaluated with the use of sequential studies: testosterone stimulation and suppression te...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：
更新日期：1986-12-01 00:00:00
abstract：OBJECTIVE:To clarify the role and mechanism of CCL2 in regulating the biological functions of endometrial stromal cells (ESCs). DESIGN:The CCL2 effect on the viability, proliferation, and invasion in the eutopic ESCs from endometriosis. SETTING:Research laboratories. PATIENT(S):Patients with endometriosis aged 23-47...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2011.12.049
更新日期：2012-04-01 00:00:00
abstract：OBJECTIVE:To compare the effects of intrauterine and subdermal administration of levonorgestrel on control of bleeding and on the endometrium in postmenopausal hormone replacement therapy. INTERVENTIONS:Nineteen women started continuous oral E2 valerate therapy (2 mg daily) together with continuous parenteral progesti...
journal_title：Fertility and sterility
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0015-0282(16)57365-8
更新日期：1995-02-01 00:00:00
abstract：OBJECTIVE:To investigate whether BRCA carriers with and without malignancy have decreased ovarian reserve at baseline compared with BRCA noncarriers. DESIGN:Retrospective cohort study. SETTING:Academic medical center. PATIENT(S):Seven-hundred and ninety-five oocyte cryopreservation patients, comprising BRCA carriers...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2018.10.014
更新日期：2019-02-01 00:00:00
abstract：:Recent in vitro studies implicate the ovary as an extra-hepatic source of insulin-like growth factors (IGFs) with production regulated by gonadotropins and local steroids. Because previous studies have failed to show any significant variations in IGF levels in peripheral blood during the menstrual cycle, we measured t...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)53221-x
更新日期：1990-01-01 00:00:00
abstract：OBJECTIVE:To study single sperm boar motility using electrical impedance measurements in a microfluidic system. DESIGN:Comparison of the optical data and electrical impedance data. SETTING:Research laboratory at a university. ANIMAL(S):Boar semen sample were used. INTERVENTION(S):A microfluidic system is developed ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2016.05.008
更新日期：2016-09-01 00:00:00
abstract：OBJECTIVE:To investigate the direct actions of active 1,25-dihydroxy vitamin D3 (VD3) upon primate follicular development at specific stages of folliculogenesis. DESIGN:Secondary preantral follicles were isolated from rhesus monkeys ovaries, encapsulated in alginate, and cultured for 40 days. Follicles were randomly a...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2016.08.037
更新日期：2016-12-01 00:00:00
abstract：OBJECTIVE:To assess the clinical value of bisulfite polymerase chain reaction Luminex (BPL), an automated, high-throughput procedure for the detection of alterations in DNA methylation. DESIGN:Experimental prospective study. SETTING:University research laboratory and private in vitro fertilization (IVF) clinic. PATI...
journal_title：Fertility and sterility
pub_type： 临床试验,杂志文章
doi：10.1016/j.fertnstert.2010.06.076
更新日期：2011-01-01 00:00:00
abstract：:In the human, hyperprolactinemia may interfere with fertility. To find out whether or not prolactin (PRL) can act directly on human ovarian tissues, in vitro studies involving specific binding of human PRL to various human ovarian elements were carried out. Human PRL was isolated from amniotic fluid, and its intact mo...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)46456-3
更新日期：1982-08-01 00:00:00
abstract：:Pain associated with endometriosis may involve many mechanisms and requires careful evaluation to confirm the diagnosis and exclude other potential causes. Both medical and surgical treatments for pain related to endometriosis are effective, and choice of treatment must be individualized. This document replaces the do...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2014.02.012
更新日期：2014-04-01 00:00:00
