当前位置： SCI文献检索 > FERTILITY AND STERILITY期刊下所有文献 > Plasma adiponectin and insulin resistance in women with polycystic ovary syndrome.

Plasma adiponectin and insulin resistance in women with polycystic ovary syndrome.

Abstract：

OBJECTIVE:To determine plasma adiponectin concentration in women with and without polycystic ovary syndrome (PCOS) and to assess possible correlations of adiponectin to the hormonal and metabolic parameters, including measures of insulin resistance (IR). DESIGN:Case-control study. SETTING:Tertiary-referral university hospital. PATIENT(S):One hundred eighty selected women were classified as follows: 45 obese (body mass index [BMI] >30 kg/m2) with PCOS; 45 lean (BMI <25 kg/m2) with PCOS; 45 obese (BMI >30 kg/m2) without PCOS, and 45 lean (BMI <25 kg/m2) without PCOS. INTERVENTION(S):Blood samples were collected from all women with or without PCOS between 8 and 11 am, after an overnight fast. MAIN OUTCOME MEASURE(S):Serum levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), thyroid-stimulating hormone (TSH), free T4, testosterone (T), 17-alpha-hydroxyprogesterone, Delta4-androstenedione (Delta4-A), dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulfate (DHEAS), sex hormone-binding globulin (SHBG), insulin, and plasma levels of adiponectin and glucose. Measures of IR included fasting serum insulin, glucose-to-insulin ratio, and homeostasis model assessment (HOMA). RESULT(S):Adiponectin concentrations were found to be significantly decreased in women with PCOS and in obese women without PCOS as compared with lean women without PCOS. Adiponectin concentrations correlated inversely with body weight, BMI, fasting plasma glucose, serum insulin, Delta4-A, DHEA, DHEAS, and HOMA but correlated positively with serum T, SHBG, FAI, and glucose-to-insulin ratio. Multiple regression analysis showed that BMI, HOMA, Delta4-A, and insulin were independent determinants of adiponectin concentrations. CONCLUSION(S):Hypoadiponectinemia is evident in obese and lean women with PCOS with variable degree of IR; and it is suggested that IR per se or other metabolic abnormalities of PCOS are involved in the regulation of adiponectin concentration in women with PCOS.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Ardawi MS,Rouzi AA

doi

10.1016/j.fertnstert.2004.11.077

keywords:

subject

Has Abstract

pub_date

2005-06-01 00:00:00

pages

1708-16

issue

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(05)00385-7

journal_volume

pub_type

杂志文章

在线工具

Plasma adiponectin and insulin resistance in women with polycystic ovary syndrome.