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Local injury of the endometrium induces an inflammatory response that promotes successful implantation.

Abstract：

OBJECTIVE:To study whether an injury-induced inflammation might be the mechanism underlying the favorable effect of endometrial biopsy on the implantation rate in in vitro fertilization (IVF) patients. DESIGN:Controlled clinical study. SETTING:A medical center IVF unit and a research institute. PATIENT(S):Women undergoing IVF who had previous failed treatment cycles. INTERVENTION(S):Endometrial samples were collected from two groups of patients on day 21 of their spontaneous menstrual cycle. The experimental, but not the control group underwent prior biopsy treatment on days 8 or/and 11 to 13 of that same cycle. MAIN OUTCOME MEASURE(S):Abundance of immune cells, cytokines/chemokines level, correlation between these parameters and pregnancy outcome. RESULT(S):A statistically significantly higher amount of macrophages/dendritic cells (HLA-DR+ CD11c+ cells) and elevated proinflammatory cytokines, tumor necrosis factor-α (TNF-α), growth-regulated oncogene-α (GRO-α), interleukin-15 (IL-15), and macrophage inflammatory protein 1B (MIP-1B), were detected in day-21 endometrial samples of the experimental group. A direct stimulatory effect of TNF-α on MIP-1B, GRO-α, and IL-15 messenger RNA (mRNA) expression was demonstrated. A positive correlation was found between the levels of macrophages/dendritic cells, MIP-1B expression, and TNF-α expression and the pregnancy outcome. CONCLUSION(S):A biopsy-induced inflammatory response may facilitate the preparation of the endometrium for implantation. Increased MIP-1B expression could possibly serve for prediction of implantation competence.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Gnainsky Y,Granot I,Aldo PB,Barash A,Or Y,Schechtman E,Mor G,Dekel N

doi

10.1016/j.fertnstert.2010.02.022

subject

Has Abstract

pub_date

2010-11-01 00:00:00

pages

2030-6

issue

6

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(10)00272-4

journal_volume

94

pub_type

杂志文章

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