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Hyperreactio luteinalis with both markedly elevated human chorionic gonadotropin levels and an imbalance of angiogenic factors subsequently developed severe early-onset preeclampsia.

Abstract：

OBJECTIVE:To report a case of hyperreactio luteinalis (HL) with elevated levels of human chorionic gonadotropin (hCG) and a severe imbalance of angiogenic factors, which developed into severe, early onset preeclampsia (PE). DESIGN:Case report. SETTING:University perinatal center. PATIENT(S):A 32-year-old primigravida woman with HL, high hCG levels, and severe imbalance of angiogenic factors who subsequently developed severe PE. INTERVENTION(S):Emergent cesarean section due to nonreassuring fetal status. MAIN OUTCOME MEASURE(S):Severe, early onset PE. RESULT(S):A case of HL was referred to our hospital for remarkably elevated hCG levels and bilaterally enlarged multicystic ovaries in the first trimester; the patient subsequently developed severe, early onset PE with a severe imbalance of angiogenic factors. Emergency cesarean section was performed, and she delivered a premature female infant weighing 1818 g at 32 week's gestational age. During her next pregnancy, the circulating levels of hCG and angiogenic factors remained normal, and she did not develop either PE or HL. CONCLUSION(S):Although HL complicated with PE is very rare, our case suggests that HL associated with both an elevated hCG level and an imbalance of angiogenic factors might be a risk/predictive factor for severe, early onset PE.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Masuyama H,Tateishi Y,Matsuda M,Hiramatrsu Y

doi

10.1016/j.fertnstert.2009.04.002

subject

Has Abstract

pub_date

2009-07-01 00:00:00

pages

393.e1-3

issue

1

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(09)00828-0

journal_volume

92

pub_type

杂志文章

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