Abstract：
OBJECTIVE:To study whether late spontaneous vacuolization on day 4 is an artefact or an alternate means of blastocele formation and to analyze its impact on pregnancy outcome and live birth. DESIGN:Prospective observational study. SETTING:University teaching hospital. PATIENT(S):A total of 424 patients who fulfilled inclusion criteria were subgrouped according to the spontaneous vacuolization on day 4: Group 1 had all morulas affected, group 2 showed no signs of vacuoles, and group 3 was mixed (some day 4 embryos had vacuoles and others did not). INTERVENTION(S):Screening for the presence of vacuoles on day 4 and fresh single-blastocyst transfer. MAIN OUTCOME MEASURE(S):Morula and blastocyst scoring, utilization rate, pregnancy and live birth rates. RESULT(S):Patients of group 1 had a reduced blastocyst formation rate on day 5 (P<.01) and significantly fewer good-quality blastocysts for usage (P<.05). In addition, pregnancy (P<.001) and live birth (P<.01) rate were significantly worse in group 1 compared with groups 2 and 3. CONCLUSION(S):Late onset of vacuolization around compaction stage is a negative predictor of blastocyst formation and outcome.
journal_name
Fertil Steriljournal_title
Fertility and sterilityauthors
Mayer RB,Shebl O,Oppelt P,Reiter E,Altmann R,Enengl S,Allerstorfer C,Ebner Tdoi
10.1016/j.fertnstert.2018.02.131subject
Has Abstractpub_date
2018-06-01 00:00:00pages
1025-1029issue
6eissn
0015-0282issn
1556-5653pii
S0015-0282(18)30207-3journal_volume
109pub_type
杂志文章abstract：:The current study was formulated to investigate the abortifacient activity of prostaglandin 15-methyl F2alpha (15-methyl PGF2alpha) administered intramuscularly to 80 healthy women with gestations between 8 and 22 weeks. Goals were the establishment of an effective dosage schedule and assessment of the incidence and s...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：
更新日期：1975-07-01 00:00:00
abstract：OBJECTIVE:To review the pregnancy and birth outcomes of patients undergoing intracytoplasmic sperm injection (ICSI). DESIGN:Selective review of the literature. SETTING:Couples undergoing either conventional IVF or ICSI and their resulting offspring. PATIENT(S):None. MAIN OUTCOME MEASURE(S):None. INTERVENTION(S):No...
journal_title：Fertility and sterility
pub_type： 杂志文章,评审
doi：10.1016/s0015-0282(03)01014-8
更新日期：2003-10-01 00:00:00
abstract：OBJECTIVE:To investigate the effects of P, medroxyprogesterone acetate (MPA), and dydrogesterone (DYD) and its metabolite, 20-alpha-dihydrodydrogesterone (DHD) on endothelial synthesis of nitric oxide (NO) and characterize the signaling events recruited by these compounds. The Women's Health Initiative trial reports an...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2006.05.018
更新日期：2006-10-01 00:00:00
abstract：OBJECTIVE:To compare the effects on human oocytes of in vitro maturation periods of 28 hours and 36 hours. DESIGN:Retrospective analysis. SETTING:University teaching hospital. PATIENT(S):A total of 48 infertile patients undergoing 55 cycles who volunteered for the experimental treatments. INTERVENTION(S):Immature o...
journal_title：Fertility and sterility
pub_type： 临床试验,杂志文章
doi：10.1016/s0015-0282(99)00574-9
更新日期：2000-03-01 00:00:00
abstract：OBJECTIVE:To study the fusiogenic ability of human spermatozoa and oocytes. DESIGN:Retrospective study of 3,027 oocytes included in a program of subzonal insemination (SUZI). SETTING:Assisted fertilization program in an academic research environment. PATIENT(S):Couples with characterized male factor infertility or p...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(97)81445-8
更新日期：1997-06-01 00:00:00
abstract：:Synthetic LH-RH is a polypeptide that is structurally identical to natural LH-RH. It has been used as a safe ovulation induction agent. A case is presented in which a patient had an anaphylactic reaction when treated with LH-RH by IV infusion. Positive skin testing confirmed this as an IgE-mediated reaction. This is t...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)59428-x
更新日期：1987-09-01 00:00:00
abstract：OBJECTIVE:To evaluate whether older first-time mothers (≥37 years) have higher rates of postpartum depression compared with younger first-time mothers, controlling for mode of conception and known risk factors for postpartum depression. DESIGN:Prospective cohort study. SETTING:Assisted reproductive technology (ART) c...
journal_title：Fertility and sterility
pub_type： 杂志文章,多中心研究
doi：10.1016/j.fertnstert.2011.08.037
更新日期：2011-11-01 00:00:00
abstract：:The first subsequent pregnancy rate in a group of women who accepted a variety of contraceptive methods after delivery and after therapeutic abortion is reviewed. Regardless of method chosen, 20 to 30% of postdelivery and 18 to 20% of postabortion patients were pregnant again after 1 year. In those patients who chose ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：
更新日期：1976-01-01 00:00:00
abstract：:Twelve adult does in estrus were artificially inseminated with 1 ml of semen from bucks that had received injections of 3H-thymidine 22 to 32 days previously. The ejaculates contained radioactive seminal plasma and unlabeled sperm. The reproductive tracts of the does were removed at selected intervals after inseminati...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)42622-1
更新日期：1977-06-01 00:00:00
abstract：OBJECTIVE:To compare the effects of solid barriers (PDLA membrane and foil, Interceed), innovative barrier solutions (Adept and Hyalobarrier Gel, phospholipid emulsion), and Ringer's lactate solution in preventing postsurgical peritoneal adhesions in the rat. DESIGN:Prospective, randomized experimental study. SETTING...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2006.05.023
更新日期：2006-10-01 00:00:00
abstract：OBJECTIVE:To investigate the effect of human oviductal cells on various sperm functions in vitro. DESIGN:Controlled experimental laboratory study. SETTING:University gynecology unit. PATIENT(S):Women undergoing tubal ligation or hysterectomy and men who were visiting our subfertility clinics. INTERVENTION(S):Cocult...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(98)00430-0
更新日期：1999-02-01 00:00:00
abstract：:A 26-year-old patient underwent pelvic lymphadenectomy and trachelectomy because of cervical cancer stage IB. Later she developed symptoms from obturator nerve entrapment. Examinations could not reveal metastatic cancer disease, but endometriosis surrounding the obturator nerve was discovered. Laparoscopic removal of ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2008.03.024
更新日期：2009-02-01 00:00:00
abstract：OBJECTIVE:To assess the association of total isoflavone intake with ovulatory function, including sporadic anovulation in healthy premenopausal women. DESIGN:Prospective cohort study. SETTING:University. PATIENT(S):Participants included 259 healthy regularly menstruating women aged 18-44 years. INTERVENTION(S):None...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2013.08.002
更新日期：2013-12-01 00:00:00
abstract：:Eleven patients underwent controlled ovarian hyperstimulation yielding 72 embryos for evaluation. Mean nitric oxide metabolite levels in the insemination media were 2.6 times higher in embryos that progressed to blastocysts by culture day 5 than in those that did not. A comparison of the receiver operating characteris...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2008.01.108
更新日期：2009-04-01 00:00:00
abstract：:A patient with Nelson's syndrome whose pregnancy was complicated by symptomatic enlargement of an ACTH-producing pituitary tumor was described. Emergency ablative surgery was performed with successful outcomes for both mother and infant. ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)48932-6
更新日期：1985-10-01 00:00:00
abstract：:A prospective randomized study was conducted in 100 women with leiomyomas in order to evaluate the effect of gestrinone, a synthetic derivative of ethynil-nor-testosterone. Patients in group A received capsules containing 2.5 mg of gestrinone three times weekly orally. Those in group B received capsules containing 5.0...
journal_title：Fertility and sterility
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0015-0282(16)60722-7
更新日期：1989-06-01 00:00:00
abstract：:Turner syndrome results in infertility in most cases. Fertility preservation through the cryopreservation of oocytes or ovarian tissue may be an option for some girls with Turner syndrome. Oocyte donation results in high pregnancy rates (PR). Those women who plan to pursue pregnancy need comprehensive screening and co...
journal_title：Fertility and sterility
pub_type： 杂志文章,评审
doi：10.1016/j.fertnstert.2012.08.022
更新日期：2012-10-01 00:00:00
abstract：OBJECTIVE:To determine whether individual subject variation in ovarian response between repeated cycles with the same ovarian stimulation protocol can be predicted. DESIGN:Retrospective data analysis. SETTING:Multicenter, open-label, uncontrolled clinical trial. PATIENT(S):Women aged 18-39 from a phase 3, open-label...
journal_title：Fertility and sterility
pub_type： 杂志文章,多中心研究
doi：10.1016/j.fertnstert.2015.06.027
更新日期：2015-10-01 00:00:00
abstract：:Freezing and storage of human male gametes is associated with a reduction in the overall semen quality and establishment of pregnancy. This study was done to evaluate the integrity of sperm head ultrastructure (SHU) with computerized and vapor freezing. Comparisons were made between the effect of cryopreservatives gly...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)49650-0
更新日期：1986-10-01 00:00:00
abstract：OBJECTIVE:To review the current literature on genes known to affect fertility in the human and mouse. DESIGN:A literature review was performed and key articles were chosen for focus in the areas of genes with effects only on spermatogenesis and oogenesis, with an emphasis on Y-chromosome-encoded gene families and sper...
journal_title：Fertility and sterility
pub_type： 杂志文章,评审
doi：10.1016/s0015-0282(98)00071-5
更新日期：1998-06-01 00:00:00
abstract：OBJECTIVE:To assess the utility of endometrial thickness, echogenic endometrial pattern, and uterine artery impedance measured as pulsativity index in predicting implantation. DESIGN:Prospective case-controlled study of infertile patients undergoing assisted reproductive technologies (ARTs). PATIENTS:Four hundred fiv...
journal_title：Fertility and sterility
pub_type： 临床试验,杂志文章
doi：10.1016/s0015-0282(16)57065-4
更新日期：1994-11-01 00:00:00
abstract：:One hundred infertile patients with laparoscopically confirmed ovarian endometriosis were treated with either intranasal (IN) Buserelin (Hoechst, AG, Frankfurt am Main, West Germany) (300 micrograms three times a day) or subcutaneous (SC) Buserelin implant (6.6 mg Buserelin). Serum estradiol was suppressed in the meno...
journal_title：Fertility and sterility
pub_type： 临床试验,杂志文章
doi：10.1016/s0015-0282(16)60783-5
更新日期：1989-07-01 00:00:00
abstract：OBJECTIVE:To investigate the influence of folic acid supplementation on the follicular fluid concentrations of folate and total homocysteine and their relationship to the diameter of the follicle. DESIGN:Observational study. SETTING:Tertiary referral fertility clinic at the Erasmus MC, University Medical Center, Rott...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2007.06.036
更新日期：2008-06-01 00:00:00
abstract：:Because spermatocyte meiotic error results in embryonic sex chromosomal aneuploidy, it is speculated that teratospermia correlates with increased embryonic sex chromosomal abnormalities. Our findings contradict this theory, suggesting that morphology does not correlate with sex chromosomal genotype. ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2009.07.1006
更新日期：2010-02-01 00:00:00
abstract：OBJECTIVE:To compare the levonorgestrel intrauterine system (LNG-IUS) with hysterectomy in patients with adenomyosis and to study the effects of both treatments on quality of life (QOL). DESIGN:Prospective randomized clinical trial. SETTING:Women's health teaching and research hospital. PATIENT(S):Eighty-six patient...
journal_title：Fertility and sterility
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.fertnstert.2010.10.009
更新日期：2011-02-01 00:00:00
abstract：:Several studies have shown a decrease in uterine and/or leiomyoma volume when treated with leuprolide acetate (LA), a widely used gonadotropin-releasing hormone agonist. The mechanism by which these changes occur is unknown. In this study, the histopathological slides of 31 women of reproductive age who underwent hyst...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)53937-5
更新日期：1990-11-01 00:00:00
abstract：OBJECTIVE:To determine the role of parental and biological factors on the U.S. male birth fraction from 1964 through 1988. DESIGN:Logistic regression on annual U.S. male births by race group. SETTING:Population-based data. PATIENT(S):Live births in the United States 1964 through 1988. INTERVENTION(S):None. MAIN OU...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(99)00576-2
更新日期：2000-03-01 00:00:00
abstract：:The dietary, behavioral and in vitro methods of sex selection are evaluated for physicians to advise patients who desire to plan the gender of their families, but for whom chorionic villus sampling and elective abortion is unacceptable. A diet based on high potassium and sodium, and low magnesium and calcium for coup...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)60000-6
更新日期：1988-07-01 00:00:00
abstract：:Examination of 12 paired peritoneal ectopic and eutopic endometria for histochemical binding of Dolichos biflorus agglutinin, normally found in the mid-late secretory part of the cycle, showed a failure of lectin binding in 9 of 11 secretory-phase lesions although the eutopic specimens generally stained normally. This...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2008.11.032
更新日期：2009-04-01 00:00:00
abstract：OBJECTIVE:To report the case of a patient submitted to laparoscopic bowel resection in whom histology revealed endometriosis and schistosomiasis. DESIGN:Case report. SETTING:Multidisciplinary group practice and teaching hospital. PATIENT(S):A 31-year-old patient with pelvic pain. INTERVENTION(S):Laparoscopic bowel ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2005.08.068
更新日期：2006-04-01 00:00:00
