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Danazol binding to rat androgen, glucocorticoid, progesterone, and estrogen receptors: correlation with biologic activity.

Abstract：

:Danazol was found to possess androgenic and glucocorticoid activity in rat bioassays. In contrast, danazol displayed no significant estrogenic activity. In support of these findings, danazol bound to the 8 S androgen receptor of rat prostate cytosol and to the glucocorticoid receptor of rat liver cytosol, but danazol did not bind well to the estrogen receptor of the rat uterus. Finally, danazol bound to the progesterone receptor of the rat uterus, but controversy continues as the whether danazol possesses progestational, antiprogestational, or no progestational effects.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Barbieri RL,Lee H,Ryan KJ

doi

10.1016/s0015-0282(16)43820-3

subject

Has Abstract

pub_date

1979-02-01 00:00:00

pages

182-6

issue

2

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(16)43820-3

journal_volume

31

pub_type

杂志文章

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