Abstract：
OBJECTIVE:To investigate changes in menstrual cycle hormones and endometrial maturation that may contribute to the decline in fertility with aging. DESIGN:Prospective controlled clinical study. SETTING:Normal human volunteers in an academic research institution. SUBJECTS:Women with regular menstrual cycles. INTERVENTIONS:Thirty-two women, aged 20 to 30 or 40 to 50 years, had daily blood drawing starting on cycle day 6 to 10 and continuing until 2 days after the onset of next menses. In addition, 60 women, aged 20 to 30 or 40 to 50 years, had a total of 93 endometrial biopsies performed on day 7 to 9 after the LH surge. MAIN OUTCOME MEASURES:Serum LH, FSH, E2, inhibin, P, and placental protein 14 (PP14) levels and histologic maturation of the endometrium. RESULTS:Serum FSH levels were increased whereas inhibin concentrations were reduced in the luteal-follicular transition of women > 40 years. No other hormonal changes were seen in this population, including P and PP14 secretion. Disruption of endometrial maturation occurred at a similar frequency in both age groups. CONCLUSIONS:Follicular recruitment, but not luteal function or endometrial maturation, is disturbed in cycling women > 40 years and may contribute to the decline in fertility with aging.
journal_name
Fertil Steriljournal_title
Fertility and sterilityauthors
Batista MC,Cartledge TP,Zellmer AW,Merino MJ,Axiotis C,Bremner WJ,Nieman LKsubject
Has Abstractpub_date
1995-09-01 00:00:00pages
492-9issue
3eissn
0015-0282issn
1556-5653pii
S0015-0282(16)57782-6journal_volume
64pub_type
杂志文章abstract：OBJECTIVE:To review the effectiveness of rectal probe electroejaculation in terms of pregnancy in treatment of anejaculatory males due to spinal cord injury. The characteristics of electroejaculates also are examined. DATA IDENTIFICATION:All English language studies reporting pregnancies as a result of electroejaculat...
journal_title：Fertility and sterility
pub_type： 杂志文章,评审
doi：
更新日期：1995-07-01 00:00:00
abstract：OBJECTIVE:Evaluate racial differences in reproducibility of hormone levels over time (estradiol, DHEAS, FSH, and testosterone) while adjusting for covariates previously identified as relevant in the study population. DESIGN:Longitudinal cohort study. SETTING:Healthy, late-reproductive-age women in a community-based s...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(00)01723-4
更新日期：2001-02-01 00:00:00
abstract：:Tamoxifen therapy in premenopausal women with breast cancer may be associated with the development of ovarian cysts. In this report, a case of ovarian torsion associated with TAM therapy is described. ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)55688-x
更新日期：1993-02-01 00:00:00
abstract：OBJECTIVE:Compare the efficiency of two vitrification methods for single-blastomere cryopreservation with mouse or human embryos. DESIGN:Experimental prospective controlled study. SETTING:Research center. PATIENT(S):Human Blastomeres were obtained after biopsy. INTERVENTION(S):Mouse blastomeres were obtained after ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2011.10.008
更新日期：2012-01-01 00:00:00
abstract：OBJECTIVE:To compare buoyant density and sedimentation kinetics of human immunodeficiency virus 1 (HIV-1) in two sperm-washing media, Percoll and Pureception. DESIGN:Laboratory study. SETTING:University hospital. PATIENT(S):None. INTERVENTION(S):Buoyant density and sedimentation kinetics of HIV-1 particles (MOLT-4/...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2007.09.025
更新日期：2008-11-01 00:00:00
abstract：:In the early years of in vitro fertilization, overall pregnancy rates were low, and it was considered necessary to transfer more than one embryo to increase the chances of pregnancy. It was not until advances in assisted reproductive technologies resulting in increased pregnancy rates that the concept of transferring ...
journal_title：Fertility and sterility
pub_type： 杂志文章,评审
doi：10.1016/j.fertnstert.2020.09.003
更新日期：2020-10-01 00:00:00
abstract：:Two women with the polycystic ovary syndrome were treated with bromocriptine (15 to 20 mg/day) in combination with spironolactone (100 mg/day). In the first woman the combined therapy induced a marked reduction of hirsutism, with ensuing ovulation and pregnancy. In the second woman, who had hyperthecosis and had been ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)45554-8
更新日期：1981-06-01 00:00:00
abstract：:The biochemical and histological features of two related patients with the complete form of the androgen insensitivity syndrome (AIS) coexisting with incomplete regression of the Müllerian ducts are described. Both patients presented unilateral Müllerian derivatives (fallopian tube) identified by microscopic examinati...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：
更新日期：1990-06-01 00:00:00
abstract：:A randomized comparison trial was performed to evaluate whether follicular reaspiration with use of a double-lumen retrieval needle improves oocyte recovery when compared with direct follicular aspiration among low-responding patients undergoing ART. There were no differences observed in the number of oocytes retrieve...
journal_title：Fertility and sterility
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.fertnstert.2008.04.034
更新日期：2009-04-01 00:00:00
abstract：OBJECTIVE:Racial disparity in assisted reproductive technology (ART) outcomes has been reported but remains controversial. Reasons for the disparity are unclear, and access to care has been suggested as a causative factor. In this study, we sought to examine minority utilization of ART in the Department of Defense (DoD...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2005.10.028
更新日期：2006-04-01 00:00:00
abstract：OBJECTIVE:To test the hypothesis that over a 4-week treatment period, Nal-Glu GnRH antagonist ([AcD2Nal1, D4ClPhe2, D3Pal3, Arg5, DGlu6 [AA], DAla10] GnRH) at a dose of 200 micrograms/kg per day SC would suppress levels of immunologically active and biologically active LH and FSH more completely than a dose of 100 micr...
journal_title：Fertility and sterility
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1995-07-01 00:00:00
abstract：:To further define the role of CO2 laser in infertility surgery, the authors compared the immediate tissue damage and the subsequent healing patterns that followed the randomized use of CO2 laser and electrocautery on opposite sides of the reproductive tracts of 20 mature, female rabbits. Blind histopathologic evaluati...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)59603-4
更新日期：1987-12-01 00:00:00
abstract：OBJECTIVE:To observe the ultrastructure of human oocytes at different maturity stages and morphologies before and after in vitro maturation. DESIGN:Case report. SETTING:University-based center for human reproduction. PATIENT(S):A 28-year-old patient with polycystic ovary syndrome undergoing IVM/IVF-ET treatment. IN...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2009.02.010
更新日期：2009-07-01 00:00:00
abstract：OBJECTIVE:To compare the efficacy of two antiandrogens, spironolactone and flutamide, in the treatment of hirsutism. PATIENTS, PARTICIPANTS:Twenty women with idiopathic hirsutism were randomized to receive either flutamide or spironolactone. DESIGN:Twenty hirsute women were recruited from patients presenting to the h...
journal_title：Fertility and sterility
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1994-04-01 00:00:00
abstract：OBJECTIVE:To determine the prevalence of idiopathic hirsutism among a population of consecutive hirsute patients. DESIGN:Prospective cohort study. SETTING:University-based clinic. PATIENT(S):Premenopausal women with a complaint of hirsutism who were not receiving hormonal therapy. INTERVENTION(S):Evaluations for to...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(98)00141-1
更新日期：1998-08-01 00:00:00
abstract：OBJECTIVE:Platelet-activating factor-acether (PAF-acether) presence was investigated in 27 human follicular fluids (FFs). DESIGN:Aggregation of washed rabbit platelets was used to measure PAF-acether. Data were compared using Student's t-test. SETTING:Follicular fluids came from the in vitro fertilization program at ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)54417-3
更新日期：1991-07-01 00:00:00
abstract：:Freshly ejaculated semen specimens from 20 normal fertile, 11 subfertile, and 20 vasectomized men whose semen analyses had reached complete azoospermia were compared. The mean levels of seminal acid phosphatase were significantly higher in the vasectomized men. The mean values of sialic acid in normal and postvasect...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)38947-6
更新日期：1972-05-01 00:00:00
abstract：:Testosterone and 19-nortestosterone derivatives were evaluated in a developmental scheme designed to identify competitive progesterone antagonists having abortifacient activity. Compounds that displayed significant binding to the rabbit uterine progesterone receptor were followed in biologic tests for progestational, ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)44003-3
更新日期：1979-05-01 00:00:00
abstract：OBJECTIVE:To evaluate concentration of granulocyte colony-stimulating factor (G-CSF) in serum and follicular fluid (FF) at the time of oocyte retrieval and to detect expression of G-CSF and its receptor by luteinized granulosa cells (GCs). DESIGN:Collection of serum and FF at the time of oocyte retrieval. SETTING:A u...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2003.09.039
更新日期：2004-03-01 00:00:00
abstract：:In this observational, case-control study in infertile women, we observed elevated serum oxidative stress that was significantly correlated with an increase in serum paraoxonase-1 activity and without any evidence of a proinflammatory reaction. These results suggest a protective role of paraoxonase-1 against inflammat...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2009.11.043
更新日期：2010-08-01 00:00:00
abstract：:Semen samples from 35 fertile men and husbands of 32 infertile couples were evaluated with the use of a rapid computerized sperm motion analysis (CSA). The counts and percentages of motile sperm measured by routine semen analysis (RSA) and CSA were comparable in both groups. In CSA, mean values of swimming speed (micr...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：
更新日期：1986-09-01 00:00:00
abstract：OBJECTIVE:To perform a highly detailed semen analysis in a man whose wife had a partial mole. DESIGN:Case report. SETTING:Gynecology departments of two university hospitals and a laboratory of histology/embryology. PATIENT(S):A 32-year-old man whose wife had a partial mole. INTERVENTION(S):Sperm characteristics wer...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2011.01.161
更新日期：2011-06-01 00:00:00
abstract：:Standardized bilateral ovarian-adrenal vein catheterization was utilized to assess directly glandular steroid release in 60 androgenized women without evidence of a functional neoplasm. Testosterone (T), dihydrotestosterone (DHT), androstenedione (delta 4 A), dehydroepiandrosterone (DHEA), DHEA sulfate (DHEA-S), 17-hy...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)47960-4
更新日期：1984-07-01 00:00:00
abstract：OBJECTIVE:To study birth outcomes among live born infants conceived by women who used infertility treatment. DESIGN:Population-based surveillance of women who recently delivered a live infant. SETTING:The birth outcomes among infants whose mothers used assisted reproductive technology (ART) or ovulation stimulation m...
journal_title：Fertility and sterility
pub_type： 杂志文章,多中心研究
doi：10.1016/j.fertnstert.2011.05.073
更新日期：2011-08-01 00:00:00
abstract：:Comparative studies have been carried out on the behavior of human and bovine spermatozoa toward homologous cervical mucus in vitro. In both cases the degree of sperm penetration and the pattern of sperm motility were influenced in a characteristic fashion by prior manipulation of the mucus: the most rapid and extensi...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：
更新日期：1980-06-01 00:00:00
abstract：OBJECTIVE:To investigate types of nerve fibers in endometrium and myometrium in women with endometriosis. DESIGN:Laboratory study using human tissue. SETTING:University-based laboratory. PATIENT(S):Women with and without endometriosis undergoing hysterectomy. INTERVENTION(S):Histologic sections of contiguous endome...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2006.12.078
更新日期：2007-10-01 00:00:00
abstract：OBJECTIVE:To measure the levels of vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMPs) induced by thrombin in endometrial stromal cells (ESC). DESIGN:Evaluation of the effects of thrombin, thrombin receptor activator peptide 6 (TRAP-6), and D-phenylalanyl-1-propyl-L arginine chloromethyl ket...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2007.11.080
更新日期：2009-02-01 00:00:00
abstract：OBJECTIVE:To study the hormonal regulation of primary and recurrent endometriosis by comparing the levels of estrogen receptors (ER) and progesterone receptors (PR) with the levels in uterine endometrium obtained simultaneously. DESIGN:Tissue samples collected at routine operations. SETTING:One university clinic. PA...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：
更新日期：1993-07-01 00:00:00
abstract：:Certain conclusions may be drawn from the present review and presentation of new data concerning the unilaterally cryptorchid patient and possible subfertility: 1. The truly undescended testis--not the retractile testis of infancy--will not descend spontaneously after 1 year of age. 2. The seminal quality of the unila...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)41889-3
更新日期：1976-06-01 00:00:00
abstract：OBJECTIVE:To report the feasibility of ovarian cyst enucleation by using a laparoendoscopic single-site trocar through a transumbilical access. DESIGN:Case reports. SETTING:Teaching and research hospital. PATIENT(S):Three patients affected by large ovarian cysts. INTERVENTION(S):Enucleation of three large ovarian c...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2009.05.060
更新日期：2009-09-01 00:00:00
