Dose effects of the gonadotropin-releasing hormone antagonist, Nal-Glu, combined with testosterone enanthate on gonadotropin levels in normal men.

Abstract:

OBJECTIVE:To test the hypothesis that over a 4-week treatment period, Nal-Glu GnRH antagonist ([AcD2Nal1, D4ClPhe2, D3Pal3, Arg5, DGlu6 [AA], DAla10] GnRH) at a dose of 200 micrograms/kg per day SC would suppress levels of immunologically active and biologically active LH and FSH more completely than a dose of 100 micrograms/kg per day. DESIGN:Placebo controlled clinical study. SETTING:A university community. SUBJECTS:Thirty normal male volunteers. INTERVENTIONS:We administered Nal-Glu at doses of 0, 100, and 200 micrograms/kg body weight per day in combination with T enanthate, 50 mg IM weekly, to separate groups of men (9 or 10 men per group) for 4 weeks. RESULTS:Serum levels of immunologically active and biologically active gonadotropins were suppressed similarly in both groups of men who received Nal-Glu; this suppression was significantly greater than in the men who received placebo + T. Local side effects were more severe in the Nal-Glu 200 micrograms/kg per day group. CONCLUSIONS:Administration of Nal-Glu in combination with T suppresses gonadotropins more completely than does T alone, but at doses > 100 micrograms/kg, gonadotropins are not suppressed additionally with larger doses of Nal-Glu. Subjects experienced greater local discomfort and side effects with the higher dosage. These findings suggest that dosages of Nal-Glu of > 100 micrograms/kg per day may have no advantage over the 100-micrograms/kg dose in a male contraceptive regimen.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Bagatell CJ,Rivier JE,Bremner WJ

subject

Has Abstract

pub_date

1995-07-01 00:00:00

pages

139-45

issue

1

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(16)57670-5

journal_volume

64

pub_type

临床试验,杂志文章,随机对照试验
  • Inhibin-B: the physiologic basis of the clomiphene citrate challenge test for ovarian reserve screening.

    abstract:OBJECTIVE:To determine inhibin-B concentrations during ovarian reserve screening in women with normal and diminished ovarian reserve as determined by the clomiphene citrate challenge test. DESIGN:Retrospective. SETTING:Tertiary fertility center. PATIENT(S):Women undergoing ovarian reserve screening for a routine fer...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/s0015-0282(97)00531-1

    authors: Hofmann GE,Danforth DR,Seifer DB

    更新日期:1998-03-01 00:00:00

  • Mechanisms regulating invasiveness and growth of endometriosis lesions in rat experimental model and in humans.

    abstract:OBJECTIVE:To compare the expression of MMP-2, TIMP-2, and TGFbeta2 mRNA in experimental and human endometriotic lesions and to assess the possibility of its cytokine regulation. DESIGN:Experimental laboratory study. SETTING:Medical center. ANIMALS AND PATIENT(S): Thirty female Wistar rats, 17 women with endometriosis...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/j.fertnstert.2009.11.024

    authors: Sotnikova NY,Antsiferova YS,Posiseeva LV,Shishkov DN,Posiseev DV,Filippova ES

    更新日期:2010-05-15 00:00:00

  • Efficacy of methotrexate treatment in extrauterine pregnancies defined by stable or increasing human chorionic gonadotropin concentrations.

    abstract:OBJECTIVE:To evaluate the efficacy of methotrexate treatment in selected cases of extrauterine pregnancy (EUP) defined by stable or increasing hCG concentration. DESIGN:Prospective cohort study. SETTING:Gynecology department of the Lis Maternity Hospital. PATIENT(S):Fifty women with EUP diagnosed whenever an intraut...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/s0015-0282(01)03256-3

    authors: Gamzu R,Almog B,Levin Y,Avni A,Jaffa A,Lessing JB,Baram A

    更新日期:2002-04-01 00:00:00

  • Association of ethnicity with involuntary childlessness and perceived reasons for infertility: baseline data from the Study of Women's Health Across the Nation (SWAN).

    abstract:OBJECTIVE:To evaluate whether ethnicity is associated with involuntary childlessness and perceived reasons for difficulties in becoming pregnant. DESIGN:Cross-sectional analysis of baseline data from a longitudinal cohort. SETTING:Multiethnic, community-based observational study of US women. PATIENT(S):Women in midl...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.fertnstert.2011.08.039

    authors: Karmon A,Hailpern SM,Neal-Perry G,Green RR,Santoro N,Polotsky AJ

    更新日期:2011-11-01 00:00:00

  • Disruption of protein phosphatase 1 complexes with the use of bioportides as a novel approach to target sperm motility.

    abstract:OBJECTIVE:To design protein phosphatase 1 (PP1)-disrupting peptides covalently coupled to inert cell-penetrating peptides (CPPs) as sychnologically organized bioportide constructs as a strategy to modulate sperm motility. DESIGN:Experimental study. SETTING:Academic research laboratory. PATIENT(S)/ANIMAL(S):Normozoos...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/j.fertnstert.2020.08.013

    authors: Silva JV,Freitas MJ,Santiago J,Jones S,Guimarães S,Vijayaraghavan S,Publicover S,Colombo G,Howl J,Fardilha M

    更新日期:2020-09-22 00:00:00

  • Variation in antimüllerian hormone concentration during the menstrual cycle may change the clinical classification of the ovarian response.

    abstract:OBJECTIVE:To assess the variability of antimüllerian hormone (AMH) concentrations in women with "adequate ovarian reserve" during unstimulated menstrual cycles and to determine the impact on clinical classifications. DESIGN:Pilot cohort study. SETTING:Private fertility clinic. PATIENT(S):Twelve consecutive women (ag...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/j.fertnstert.2013.01.132

    authors: Hadlow N,Longhurst K,McClements A,Natalwala J,Brown SJ,Matson PL

    更新日期:2013-05-01 00:00:00

  • Male obesity and alteration in sperm parameters.

    abstract:OBJECTIVE:To study the effect of male obesity on sperm parameters and erectile dysfunction. DESIGN:Retrospective analysis. SETTING:Referral fertility center. PATIENT(S):Couples presenting for infertility treatment. INTERVENTION(S):On presentation, all men reported their weight and height and filled out an intake fo...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/j.fertnstert.2007.10.011

    authors: Hammoud AO,Wilde N,Gibson M,Parks A,Carrell DT,Meikle AW

    更新日期:2008-12-01 00:00:00

  • Blastocoele expansion degree predicts live birth after single blastocyst transfer for fresh and vitrified/warmed single blastocyst transfer cycles.

    abstract:OBJECTIVE:To evaluate the independent effects of the degree of blastocoele expansion and re-expansion and the inner cell mass (ICM) and trophectoderm (TE) grades on predicting live birth after fresh and vitrified/warmed single blastocyst transfer. DESIGN:Retrospective study. SETTING:Reproductive medical center. PATI...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/j.fertnstert.2015.12.014

    authors: Du QY,Wang EY,Huang Y,Guo XY,Xiong YJ,Yu YP,Yao GD,Shi SL,Sun YP

    更新日期:2016-04-01 00:00:00

  • Embryo implantation during menstruation in the absence of adequate estradiol and progesterone support, with subsequent normal response to ovulation induction and superfetation.

    abstract:OBJECTIVE:To report an unusual case of embryo implantation and superfetation. DESIGN:Retrospective case analysis. SETTING:Oak Brook Fertility Center. PATIENT(S):A 41-year-old woman underwent two consecutive ovarian stimulation cycles interrupted by a normal menstrual period. Ovulation and implantation occurred durin...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/s0015-0282(97)00244-6

    authors: Dmowski WP,DeOrio L,Rana N

    更新日期:1997-09-01 00:00:00

  • Ovarian reserve, response to gonadotropins, and oocyte maturity in women with malignancy.

    abstract:OBJECTIVE:To study the ovarian reserve, ovarian response to gonadotropins, and oocyte maturity in women with cancer undergoing in vitro fertilization (IVF) before chemotherapy or radiotherapy. DESIGN:Case-control study. SETTING:University teaching hospital. PATIENT(S):We evaluated all women with malignancy who under...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/j.fertnstert.2011.04.070

    authors: Das M,Shehata F,Moria A,Holzer H,Son WY,Tulandi T

    更新日期:2011-07-01 00:00:00

  • Using semen flow cytometry to evaluate association of ploidy status and chromatin condensation of spermatozoa with conventional semen parameters: clinical application in intrauterine insemination.

    abstract:OBJECTIVE:To evaluate the association between the ploidy status and the nuclear chromatin condensation of spermatozoa with conventional semen parameters by using semen flow cytometry (SFC). The prognostic value of SFC on the successful outcome of intrauterine insemination (IUI) was examined. DESIGN:Prospective study. ...

    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章

    doi:10.1016/j.fertnstert.2010.05.012

    authors: Lazaros L,Kaponis A,Vartholomatos G,Hatzi E,Botsari S,Plachouras N,Makrydimas G,Zikopoulos K,Sofikitis N,Georgiou I

    更新日期:2011-01-01 00:00:00

  • The sperm stress test: a novel test that predicts pregnancy in assisted reproductive technologies.

    abstract:OBJECTIVE:To develop a reliable sperm test that would predict pregnancy rate in assisted reproductive technologies. DESIGN:Blind prospective cohort study. SETTING:Tertiary-care, university hospital-affiliated IVF program. PATIENTS:One hundred nineteen sperm samples were obtained from 110 males from couples undergoin...

    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章

    doi:10.1016/s0015-0282(16)58107-2

    authors: Alvarez JG,Minaretzis D,Barrett CB,Mortola JF,Thompson IE

    更新日期:1996-02-01 00:00:00

  • Defragmentation of low grade day 3 embryos resulted in sustained reduction in fragmentation, but did not improve compaction or blastulation rates.

    abstract::In a prospective randomized fashion, this study evaluated embryo development in vitro after defragmentation versus assisted hatching alone of low grade day 3 embryos. Although a sustained decrease in day 5 fragmentation was observed in the defragmented group versus the assisted hatching only group, no difference in co...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/j.fertnstert.2010.03.014

    authors: Keltz M,Fritz R,Gonzales E,Ozensoy S,Skorupski J,Stein D

    更新日期:2010-11-01 00:00:00

  • Birth outcomes of intended pregnancies among women who used assisted reproductive technology, ovulation stimulation, or no treatment.

    abstract:OBJECTIVE:To study birth outcomes among live born infants conceived by women who used infertility treatment. DESIGN:Population-based surveillance of women who recently delivered a live infant. SETTING:The birth outcomes among infants whose mothers used assisted reproductive technology (ART) or ovulation stimulation m...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.fertnstert.2011.05.073

    authors: D'Angelo DV,Whitehead N,Helms K,Barfield W,Ahluwalia IB

    更新日期:2011-08-01 00:00:00

  • The expression of CD9 in the peri-implantation mouse uterus is upregulated in an ovarian steroid hormone-dependent manner.

    abstract:OBJECTIVE:To examine the spatiotemporal expression of CD9 protein in the peri-implantation mouse uterus as well as the effects of ovarian steroid hormones on CD9. DESIGN:Experimental animal study. SETTING:Reproductive biological center of Chinese Academy of Sciences. ANIMAL(S):Female Kunming white strain mice (6-8 w...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/j.fertnstert.2006.07.1525

    authors: Weimin L,Yujing C,Jing L,Zeng H,Ping Z,Enkui D

    更新日期:2007-03-01 00:00:00

  • Placental expression profiling in preeclampsia: local overproduction of hemoglobin may drive pathological changes.

    abstract:OBJECTIVE:To create a library enriched in cDNAs from preeclamptic placentas to print onto microarrays for placental profiling of preeclampsia (PE) and high risk pregnancies. DESIGN:Prospective study. SETTING:University women's clinic and academic research laboratory. PATIENT(S):Ten patients with PE, 5 with PE and bi...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/j.fertnstert.2007.09.030

    authors: Centlow M,Carninci P,Nemeth K,Mezey E,Brownstein M,Hansson SR

    更新日期:2008-11-01 00:00:00

  • European view of subspecialty training on behalf of the European Society of Human Reproduction and Embryology (ESHRE).

    abstract::Specialist training in reproductive medicine within Europe continues to evolve. Recent revisions, updates, and initiatives have helped to refine the core educational needs for the specialist trainee. ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,评审

    doi:10.1016/j.fertnstert.2015.05.025

    authors: Calhaz-Jorge C,Feki A,Farquharson R

    更新日期:2015-07-01 00:00:00

  • Long-acting gonadotropin hormone-releasing hormone analog used to treat uteri.

    abstract::Because the size of leiomyomata uteri often decreases significantly after menopause, the authors elected to employ a long-acting gonadotropin hormone-releasing hormone analog (GnRH-alpha) (imbzl-D-His6-Pro9-Net-GnRH) to create a state of pseudomenopause in six patients with leiomyomata uteri diagnosed on the basis of ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/s0015-0282(16)49332-5

    authors: Coddington CC,Collins RL,Shawker TH,Anderson R,Loriaux DL,Winkel CA

    更新日期:1986-05-01 00:00:00

  • Long-term outcome of parenthood project during in vitro fertilization and after discontinuation of unsuccessful in vitro fertilization.

    abstract:OBJECTIVE:To explore the long-term outcome of patients who began IVF treatment by considering not only treatment outcome in the center but also the parenthood project outcome after discontinuation of unsuccessful IVF. DESIGN:Retrospective cohort follow-up study. SETTING:Two French IVF centers. PATIENT(S):Seven hundr...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/j.fertnstert.2008.05.067

    authors: de La Rochebrochard E,Quelen C,Peikrishvili R,Guibert J,Bouyer J

    更新日期:2009-07-01 00:00:00

  • Seminal vesicles: a source of trophoblast lymphocyte cross-reactive antigen.

    abstract::Maternal recognition of allotypic trophoblast lymphocyte cross-reactive (TLX) antigens is proposed to be involved in immunologic acceptance of the allogeneic fetus. The presence of TLX antigens in seminal plasma suggests that sensitization can occur before fertilization and implantation. In this study, the origin of T...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/s0015-0282(16)60920-2

    authors: Thaler CJ,Critser JK,McIntyre JA,Faulk WP

    更新日期:1989-09-01 00:00:00

  • Hyperhomocysteinemia and recurrent early pregnancy loss: a meta-analysis.

    abstract:OBJECTIVE:To quantify the risk of recurrent early pregnancy loss in the presence of elevated fasting or afterload homocysteine concentrations or homozygosity for the 677C-->T mutation in the methylenetetrahydrofolate reductase (MTHFR) gene (T/T genotype). DESIGN:Case-control studies published between January 1992 and ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,meta分析

    doi:10.1016/s0015-0282(00)01595-8

    authors: Nelen WL,Blom HJ,Steegers EA,den Heijer M,Eskes TK

    更新日期:2000-12-01 00:00:00

  • Efficacy of selection criteria for ovarian reserve screening using the clomiphene citrate challenge test in a tertiary fertility center population.

    abstract:OBJECTIVE:To examine selection criteria for ovarian reserve screening. DESIGN:Retrospective study. PATIENTS:Two hundred nineteen women underwent testing for ovarian reserve for woman's age > 35 years, any age with unexplained infertility, one ovary, or a poor response to hMG. INTERVENTIONS:Clomiphene citrate challen...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/s0015-0282(16)58386-1

    authors: Hofmann GE,Sosnowski J,Scott RT,Thie J

    更新日期:1996-07-01 00:00:00

  • Consecutive gonadotropin-releasing hormone-antagonist in vitro fertilization cycles: does the elapsed time interval between successive treatments affect outcomes?

    abstract:OBJECTIVE:To determine whether patients who failed an in vitro fertilization (IVF) cycle can proceed with a subsequent IVF cycle after waiting only one menstrual cycle, or whether there is a benefit to allowing two or more menstrual cycles to elapse before proceeding. DESIGN:Retrospective cohort study. SETTING:Academ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/j.fertnstert.2012.11.044

    authors: Reichman DE,Chung P,Meyer L,Greenwood E,Davis O,Rosenwaks Z

    更新日期:2013-04-01 00:00:00

  • Impact of infertility treatments on the health of newborns.

    abstract:OBJECTIVE:To measure the use of infertility treatments in the general population and their association with neonatal health. DESIGN:Cross-sectional, population-based study. SETTING:Canton of Vaud, Switzerland; Etude du Developpement des Nouveau-nés (EDEN), a prospective study of chronic childhood conditions. PATIENT...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/s0015-0282(97)00468-8

    authors: Addor V,Santos-Eggimann B,Fawer CL,Paccaud F,Calame A

    更新日期:1998-02-01 00:00:00

  • Stromal cells from endometriotic lesions and endometrium from women with endometriosis have reduced decidualization capacity.

    abstract:OBJECTIVE:To evaluate the phenotype, proliferative, and differentiation capacities in vitro of stromal cells derived from peritoneal, ovarian, and deeply infiltrating endometriosis. DESIGN:Experimental study using phase contrast microscopy, immunocytochemistry, and functional bioassays. SETTING:University-based labor...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/j.fertnstert.2005.08.046

    authors: Klemmt PA,Carver JG,Kennedy SH,Koninckx PR,Mardon HJ

    更新日期:2006-03-01 00:00:00

  • Luteal start vaginal micronized progesterone improves pregnancy success in women with recurrent pregnancy loss.

    abstract:OBJECTIVE:To assess the effectiveness of luteal start vaginal micronized P in a recurrent pregnancy loss (RPL) cohort. DESIGN:Observational cohort study using prospectively collected data. SETTING:Not applicable. PATIENT(S):Women seen between 2004 and 2012 with a history of two or more unexplained pregnancy losses <...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/j.fertnstert.2016.11.029

    authors: Stephenson MD,McQueen D,Winter M,Kliman HJ

    更新日期:2017-03-01 00:00:00

  • Transfer of cryopreserved-thawed pre-embryos in a natural cycle or a programmed cycle with exogenous hormonal replacement yields similar pregnancy results.

    abstract:OBJECTIVE:To examine the results of 7 years of thawed ET during natural or controlled cycles using exogenous steroids. DESIGN:Retrospective evaluation to compare implantation and pregnancy rates with two protocols for transfer of cryopreserved-thawed pre-embryos. SETTING:Tertiary care academic center. PATIENTS:From ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/s0015-0282(16)56943-x

    authors: Queenan JT Jr,Veeck LL,Seltman HJ,Muasher SJ

    更新日期:1994-09-01 00:00:00

  • Assisted reproductive technologies in Canada: 2005 results from the Canadian Assisted Reproductive Technologies Register.

    abstract:OBJECTIVE:To present a report on assisted reproductive technologies (ART) cycles performed in 2005 in Canada. This is the fifth annual report from the Canadian ART Register (CARTR). DESIGN:Prospective cohort study. SETTING:Twenty-five of 25 ART centers in Canada. PARTICIPANT(S):Couples undergoing ART treatment in Ca...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/j.fertnstert.2008.02.125

    authors: Gunby J,Bissonnette F,Librach C,Cowan L,IVF Directors Group of the Canadian Fertility and Andrology Society.

    更新日期:2009-05-01 00:00:00

  • Congenital anomalies and assisted reproductive technology: more of the same.

    abstract::Klemetti's birth registry study is put in context of other major studies. Summary advice is offered to practitioners as to what they should tell parents who conceive with assisted reproductive technology. ...

    journal_title:Fertility and sterility

    pub_type: 评论,信件

    doi:10.1016/j.fertnstert.2005.04.067

    authors: Sutcliffe AG

    更新日期:2005-11-01 00:00:00

  • The relationship between coping and depression in men and women referred for in vitro fertilization.

    abstract::This study examined coping with infertility and how coping is related to depression for men and women. Results showed that both men and women who engage in a disproportionate degree of escape/avoidance behavior and acceptance of responsibility for infertility were more vulnerable to symptoms of depression. ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/j.fertnstert.2005.09.020

    authors: Peterson BD,Newton CR,Rosen KH,Skaggs GE

    更新日期:2006-03-01 00:00:00