当前位置： SCI文献检索 > FERTILITY AND STERILITY期刊下所有文献 > Immunoneutralization of gonadotropin-releasing hormone and subsequent treatment with testosterone Silastic implants in rats: an approach toward developing a male contraceptive.

Immunoneutralization of gonadotropin-releasing hormone and subsequent treatment with testosterone Silastic implants in rats: an approach toward developing a male contraceptive.

Abstract：

STUDY OBJECTIVE:To determine the extent to which increasing doses of exogenous testosterone (T) administered via Silastic implants can restore spermatogenesis and fertility to rats made azoospermic by active immunization against gonadotropin-releasing hormone (GnRH). DESIGN:Male rats were made azoospermic by active immunization against GnRH. Increasing doses of exogenously administered T (via Silastic implants) were administered for 8 weeks, and testicular sperm concentration and ability to impregnate female rats were evaluated. SETTING:Reproductive Endocrinology Laboratory, Department of Obstetrics and Gynecology, University of Colorado Health Sciences Center, Denver, Colorado. ANIMALS:Sexually mature male Sprague Dawley rats (SASCO, Omaha, NE). RESULTS:Suppression of gonadotropins and azoospermia was achieved by actively immunizing rats against GnRH. Testosterone was capable of restoring quantitatively complete spermatogenesis and fertility in GnRH-immunized azoospermic rats. This relationship was dose-dependent, as evidenced by the partial restoration of spermatogenesis and fertility observed in animals replaced with smaller T Silastic implants. CONCLUSION:Gonadotropin-releasing hormone immunization and T-filled Silastic implants may provide a model to study isolated gonadotropin deficiency and for the development of a reversible male contraceptive.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Awoniyi CA,Kim WK,Hurst BS,Schlaff WD

doi

10.1016/s0015-0282(16)55192-9

keywords:

subject

Has Abstract

pub_date

1992-08-01 00:00:00

pages

403-8

issue

2

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(16)55192-9

journal_volume

58

pub_type

杂志文章

相关文献

FERTILITY AND STERILITY文献大全
  • Amino acid and protein concentrations of human follicular fluid.

    abstract：:The amino acid and protein composition of human follicular fluid, obtained during surgery from women with polycystic ovaries, and of a simultaneously obtained sample of blood plasma were studied. In general, amino acid concentrations were higher in follicular fluid than in blood plasma: only the concentration of Cys w...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(16)42324-1

    authors： Velazquez A,Reyes A,Chargoy J,Rosado A

    更新日期：1977-01-01 00:00:00

  • Comparison of the effect of oral and transdermal hormone therapy on fasting and postmethionine homocysteine levels.

    abstract：OBJECTIVE:To compare the modifications on basal and post-methionine homocysteine (Hcy) levels induced by transdermal vs. oral continuous combined hormone therapy (HT). DESIGN:Prospective randomized study. SETTING:Outpatient service at university hospital. PATIENT(S):Twenty-four healthy postmenopausal women. INTERVE...

    journal_title：Fertility and sterility

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/j.fertnstert.2003.05.026

    authors： Cagnacci A,Malmusi S,Zanni AL,Alessandrini C,Caretto S,Volpe A

    更新日期：2004-01-01 00:00:00

  • The uterus and fertility.

    abstract：OBJECTIVE:To review the current understanding of the role the uterus plays in embryo implantation and to outline congenital anomalies and acquired diseases that impact normal uterine function. DESIGN:The publications related to the embryo implantation, Mullerian anomalies, uterine polyps, uterine synechiae, and myomas...

    journal_title：Fertility and sterility

    pub_type： 杂志文章,评审

    doi：10.1016/j.fertnstert.2007.09.069

    authors： Taylor E,Gomel V

    更新日期：2008-01-01 00:00:00

  • Liver function tests in women using intravaginal spermicide nonoxynol-9.

    abstract：:The effects of intravaginal application of nonoxynol-9 (N-9) on hematological parameters, routine liver function biochemistry (bilirubin, serum bile acid, SGOT, SGPT, GGT, alkaline phosphatase), and serum lipids (cholesterol and triglyceride) were evaluated in 10 normal women who received 150 mg N-9 daily for 14 conse...

    journal_title：Fertility and sterility

    pub_type： 信件

    doi：10.1016/s0015-0282(16)46058-9

    authors： Chvapil M,Droegemueller W,Earnest DL

    更新日期：1982-02-01 00:00:00

  • Reactive oxygen species in human semen: validation and qualification of a chemiluminescence assay.

    abstract：OBJECTIVE:To standardize and validate an assay for reactive oxygen species (ROS) in human semen. DESIGN:ROS levels assayed in blanks, negative and positive control samples (30% H2O2), and human semen, with the use of a luminol-based chemiluminescence assay measured in a single tube luminometer. SETTING:Andrology labo...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2014.09.009

    authors： Vessey W,Perez-Miranda A,Macfarquhar R,Agarwal A,Homa S

    更新日期：2014-12-01 00:00:00

  • Pretreatment with estrogen does not affect IVF-ICSI cycle outcome compared with no pretreatment in GnRH antagonist protocol: a prospective randomized trial.

    abstract：OBJECTIVE:To assess effects of estrogen pretreatment in GnRH antagonist protocol. DESIGN:Prospective, randomized multicenter study. SETTING:Ten private or university-based centers. PATIENT(S):A total of 472 patients undergoing IVF/ICSI. INTERVENTION(S):Randomization by sealed envelopes to receive 17β-estradiol (4 m...

    journal_title：Fertility and sterility

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.fertnstert.2012.02.028

    authors： Cédrin-Durnerin I,Guivarc'h-Levêque A,Hugues JN,Groupe d'Etude en Médecine et Endocrinologie de la Reproduction.

    更新日期：2012-06-01 00:00:00

  • In vitro fertilization without ovarian stimulation: a simplified protocol applied in 80 cycles.

    abstract：:Ovulation induction with various hormonal agents has become a standard component of in vitro fertilization (IVF) cycles to obtain multiple oocytes. Failure to anticipate the retrieval of more than two oocytes often results in cancellation of the cycle. In this study, we report our results in 80 unstimulated IVF cycles...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(16)60974-3

    authors： Foulot H,Ranoux C,Dubuisson JB,Rambaud D,Aubriot FX,Poirot C

    更新日期：1989-10-01 00:00:00

  • Oxyphenbutazone--an adjuvant to be used in prevention of adhesions in operations for fertility.

    abstract：:A laparotomy was performed in 40 rats and the cecum was subjected to a standardized trauma. Half the rats were treated with oxyphenbutazone in a dose of 40 mg/kg body weight daily for 14 days. The remaining 20 rats served as controls. All of the rats were killed 2 weeks after the laparotomy, and the number of intraper...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(16)42731-7

    authors： Larsson B,Svanberg SG,Swolin K

    更新日期：1977-08-01 00:00:00

  • Minimum standards for practices offering assisted reproductive technologies: a committee opinion.

    abstract：:This document is designed to provide a framework for assisted reproductive technology (ART) programs that meet or exceed the requirements suggested by the Centers for Disease Control and Prevention (CDC) for certification of ART laboratories. This document replaces the document, "Revised Minimum Standards for Practices...

    journal_title：Fertility and sterility

    pub_type： 杂志文章,实务指引

    doi：10.1016/j.fertnstert.2019.11.024

    authors： Practice Committee of the American Society for Reproductive Medicine.,Practice Committee of the Society for Assisted Reproductive Technology.,Practice Committee of the Society of Reproductive Biologists and Technologists. Electronic address: asrm@as

    更新日期：2020-03-01 00:00:00

  • Postoperative adhesion formation after ovarian wedge resection with and without ovarian reconstruction in the rabbit.

    abstract：:A rabbit model was used to examine adhesion formation after ovarian wedge resection with and without reapproximation of the ovarian cortex. A wedge resection was completed on one ovary with a scalpel, and the ovarian cortex was reapproximated using microsurgical technique. In the contralateral ovary, a wedge resection...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：

    authors： Brumsted JR,Deaton J,Lavigne E,Riddick DH

    更新日期：1990-04-01 00:00:00

  • Fertility preservation in women with breast cancer undergoing adjuvant chemotherapy: a systematic review.

    abstract：OBJECTIVE:To investigate methods of fertility preservation in younger women exposed to adjuvant chemotherapy for breast cancer. DESIGN:Systematic review of literature. SETTING:Academic Department of Medical Oncology. PATIENT(S):Premenopausal women exposed to adjuvant chemotherapy for breast cancer. MAIN OUTCOME MEA...

    journal_title：Fertility and sterility

    pub_type： 杂志文章,评审

    doi：10.1016/j.fertnstert.2009.02.055

    authors： Cruz MR,Prestes JC,Gimenes DL,Fanelli MF

    更新日期：2010-06-01 00:00:00

  • Compounds interfering with ovum implantation and development. I. Alkaloids and antimetabolites.

    abstract：:The alkaloids ergocornine, vinblastine, and colcemide, with reported effects interfering with ovum implantation and development were investigated in the white New Zealand rabbit and the macaque monkey. 3 antimetabolites, 5-fluorouracil, 6-azauridine, and BW 57-323H, the 6 mercaptopurine derivative, were also investig...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(16)36181-7

    authors： Morris JM,Van Wagenen G,Hurteau GD,Johnston DW,Carlsen RA

    更新日期：1967-01-01 00:00:00

  • Human semen relaxin and its correlation with the parameters of semen analysis.

    abstract：:The relaxin content of 92 normal semen samples and 85 semen samples selected at random was correlated to the parameters measured on routine semen analysis in those samples. The concentration of immunoactive relaxin in a sample of semen plasma did not correlate with any of the parameters commonly used for semen analysi...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(16)59130-4

    authors： Brenner SH,Lesing JB,Schoenfeld C,Goldsmith LT,Amelar R,Dubin L,Weiss G

    更新日期：1987-04-01 00:00:00

  • Studies of gene expression in human cumulus cells indicate pentraxin 3 as a possible marker for oocyte quality.

    abstract：OBJECTIVE:To search for differentially expressed genes in cumulus cells from two groups of oocytes with different developmental outcome in vitro. DESIGN:Analyses of gene expression in human cumulus cells from oocytes that failed to fertilize in vitro (group A) and those that developed into normal-appearing embryos on ...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2004.11.030

    authors： Zhang X,Jafari N,Barnes RB,Confino E,Milad M,Kazer RR

    更新日期：2005-04-01 00:00:00

  • Gonadotropin-releasing hormone antagonist administration enhances gonadotrope responsiveness at doses inadequate to suppress immunoassayable gonadotropin levels.

    abstract：:Chronic GnRH antagonist therapy produces enhanced gonadotrope responsiveness to supraphysiologic stimuli despite the lack of any measurable suppression of gonadotropin levels. This indicates that GnRH antagonists fundamentally alter gonadotrope response mechanisms without inhibiting gonadotropin release. Beyond the ph...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：

    authors： Scott RT Jr,Illions EH,Carey KD,Navot D

    更新日期：1994-11-01 00:00:00

  • Mayer-Rokitansky-Küster-Hauser syndrome associated with thrombocytopenia-absent radius syndrome.

    abstract：OBJECTIVE:To describe the association of Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome and thrombocytopenia-absent radius (TAR) syndrome. DESIGN:Descriptive case report. SETTING:Tertiary university-affiliated care and referral facility. PATIENT(S):A 22-year-old woman with TAR syndrome referred to our department wit...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2004.06.077

    authors： Griesinger G,Dafopoulos K,Schultze-Mosgau A,Schroder A,Felberbaum R,Diedrich K

    更新日期：2005-02-01 00:00:00

  • Requirements for research investigations to clarify the relationships and management of menstrual abnormalities in women with hemostatic disorders.

    abstract：:This article highlights a comprehensive range of research investigations which are required to clarify the relationships between the symptom of excessively heavy menstrual bleeding and different disorders of systemic hemostasis and their management. The need for these investigations was stimulated by an international ...

    journal_title：Fertility and sterility

    pub_type： 杂志文章,评审

    doi：10.1016/j.fertnstert.2005.07.1268

    authors： Fraser IS,Bonnar J,Peyvandi F

    更新日期：2005-11-01 00:00:00

  • Anti-annexin V antibodies in patients with early pregnancy loss or implantation failures.

    abstract：OBJECTIVE:To describe the prevalence of annexin V antibodies (aANX) in women with early recurrent pregnancy losses (RPLs) or recurrent IVF-ET failure. DESIGN:Retrospective data analysis. SETTING:Tokai University Hospital, Kanagawa, Japan. PATIENT(S):Two hundred thirty-eight patients with RPLs, 48 patients with recur...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(01)02009-x

    authors： Matsubayashi H,Arai T,Izumi S,Sugi T,McIntyre JA,Makino T

    更新日期：2001-10-01 00:00:00

  • Differences in seminal parameters in specimens collected via intercourse and incomplete intercourse (coitus interruptus)

    abstract：:Whatever the mechanism of such improvements may be, the results in this study point out that coitus interruptus in the human may not be the method of choice for collection of semen specimens, especially in patients with spermatogenic dysfunctions such as hypospermia, oligospermia, and asthenospermia. It should also be...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(16)56779-x

    authors： Zavos PM,Kofinas GD,Sofikitis NV,Zarmakoupis PN,Miyagawa I

    更新日期：1994-06-01 00:00:00

  • Endometrial expression of relaxin and relaxin receptor in endometriosis.

    abstract：:Our studies demonstrate significantly lower expression of relaxin and its receptor in ectopic endometriotic tissues than their expression in eutopic endometrium and in endometrium from normal controls. These data suggest that in normal and eutopic endometrium, relaxin may exert a protective effect against endometriosi...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2010.06.051

    authors： Morelli SS,Petraglia F,Weiss G,Luisi S,Florio P,Wojtczuk A,Goldsmith LT

    更新日期：2010-12-01 00:00:00

  • Controlled ovarian hyperstimulation and transvaginal intratubal insemination as an alternative to gamete intrafallopian transfer.

    abstract：OBJECTIVE:To evaluate the efficacy of controlled ovarian hyperstimulation (COH) followed by intratubal insemination in the treatment of infertility. DESIGN:Retrospective analysis of 179 intratubal insemination trials in 78 women over a 48-month period. SETTING:Reproductive endocrinology practice. PATIENTS:Seventy-ei...

    journal_title：Fertility and sterility

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0015-0282(16)57854-6

    authors： Toaff ME,Gross ST,Lev-Toaff AS

    更新日期：1995-10-01 00:00:00

  • Accumulation of nicotine in the uterine fluid of the six-day pregnant rabbit.

    abstract：:In 6-day pregnant New Zealand White rabbits dosed intravenously with 3H-nicotine, the 3H-activity in the uterine fluid was approximately 5 to 11 times greater than that in the plasma at the corresponding times; 3H-nicotine itself accounted for most of this radioactivity. Dichlorodiphenyltrichloroethane (DDT) also accu...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：

    authors： McLachlan JA,Dames NM,Sieber SM,Fabro S

    更新日期：1976-10-01 00:00:00

  • A comparison study of a novel stimulation protocol and the conventional low dose step-up and step-down regimens in patients with polycystic ovary syndrome undergoing in vitro fertilization.

    abstract：OBJECTIVE:To compare the efficacy of a sequential step-up/step-down protocol with the conventional low dose step-up and the step-down regimens in patients with polycystic ovary syndrome (PCOS) undergoing IVF. DESIGN:Prospective randomized study. SETTING:Private fertility clinic. PATIENT(S):Two hundred twenty-five, 3...

    journal_title：Fertility and sterility

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.fertnstert.2007.06.080

    authors： Koundouros SN

    更新日期：2008-09-01 00:00:00

  • Relation between indices of semen analysis and pregnancy rate in infertile couples.

    abstract：:Both partners of 198 consecutive infertile couples were evaluated. Studies in the female included clinical evaluation of ovulation for a minimum of two menstrual cycles, investigation of tubal patency, and evaluation of sperm survival in cervical mucus. Six semen specimens were analyzed from each male. Laparoscopy, sc...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(16)42976-6

    authors： Smith KD,Rodriguez-Rigau LJ,Steinberger E

    更新日期：1977-12-01 00:00:00

  • Effect of danazol in vitro and in vivo on monocyte-mediated enhancement of endometrial cell proliferation in women with endometriosis.

    abstract：OBJECTIVE:To investigate danazol's effect in vitro and in vivo on the ability of peripheral blood monocytes (PBM) from women with endometriosis to stimulate endometrial cell proliferation. DESIGN:Uterine endometrial cells from untreated or danazol-treated patients with endometriosis were cultured with or without autol...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：

    authors： Braun DP,Gebel H,Dmowski WP

    更新日期：1994-07-01 00:00:00

  • Videolaseroscopy for the treatment of endometriosis associated with infertility.

    abstract：:Recent advances in laparoscopic surgery have enabled the gynecologic surgeon to treat an increased number of diseases of the reproductive organs by using the laser through the laparoscope. This article reviews the results of 243 patients with infertility associated with endometriosis ranging in severity from mild to e...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(16)60483-1

    authors： Nezhat C,Crowgey S,Nezhat F

    更新日期：1989-02-01 00:00:00

  • The psychological effects of multifetal pregnancy reduction.

    abstract：OBJECTIVE:To study the psychological effects of multifetal pregnancy reduction. DESIGN AND SETTING:Hour-long semistructured telephone interviews with both multifetal pregnancy reduction patients and control subjects. PATIENTS:Forty-two multifetal pregnancy reduction patients were contacted within 1 year of undergoing...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：

    authors： McKinney M,Downey J,Timor-Tritsch I

    更新日期：1995-07-01 00:00:00

  • Impairment of the developmental potential of frozen-thawed human zygotes obtained after intracytoplasmic sperm injection.

    abstract：OBJECTIVE:To evaluate the effects of cryopreservation on the survival, cleavage, and morphology of embryos and on the implantation and embryonic loss rates of human zygotes obtained after ICSI compared with frozen-thawed zygotes obtained after traditional IVF. A further objective was to evaluate the same parameters in ...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(98)00021-1

    authors： Macas E,Imthurn B,Borsos M,Rosselli M,Maurer-Major E,Keller PJ

    更新日期：1998-04-01 00:00:00

  • Forty years of IVF.

    abstract：:This monograph, written by the pioneers of IVF and reproductive medicine, celebrates the history, achievements, and medical advancements made over the last 40 years in this rapidly growing field. ...

    journal_title：Fertility and sterility

    pub_type： 历史文章,杂志文章,评审

    doi：10.1016/j.fertnstert.2018.06.005

    authors： Niederberger C,Pellicer A,Cohen J,Gardner DK,Palermo GD,O'Neill CL,Chow S,Rosenwaks Z,Cobo A,Swain JE,Schoolcraft WB,Frydman R,Bishop LA,Aharon D,Gordon C,New E,Decherney A,Tan SL,Paulson RJ,Goldfarb JM,Brännström

    更新日期：2018-07-15 00:00:00

  • Usual dietary isoflavone intake and reproductive function across the menstrual cycle.

    abstract：OBJECTIVE:To assess the association of total isoflavone intake with ovulatory function, including sporadic anovulation in healthy premenopausal women. DESIGN:Prospective cohort study. SETTING:University. PATIENT(S):Participants included 259 healthy regularly menstruating women aged 18-44 years. INTERVENTION(S):None...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2013.08.002

    authors： Filiberto AC,Mumford SL,Pollack AZ,Zhang C,Yeung EH,Schliep KC,Perkins NJ,Wactawski-Wende J,Schisterman EF

    更新日期：2013-12-01 00:00:00