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Effect of long-term intranasal oxytocin on sexual dysfunction in premenopausal and postmenopausal women: a randomized trial.

Abstract：

OBJECTIVE:To assess the effect of on-demand intranasal oxytocin administration on female sexual function and activity. DESIGN:Randomized, prospective, double-blind, placebo-controlled, crossover trial with duration of 22 weeks. SETTING:Academic medical center. PATIENT(S):Thirty pre-and postmenopausal women with sexual dysfunction. INTERVENTION(S):Over 8 weeks, intranasal oxytocin (32 IU) or placebo self-administered by women within 50 minutes before sexual intercourse; after a washout period of 2 weeks, crossover with patients switched to the alternate group for another 8 weeks. MAIN OUTCOME MEASURE(S):Primary outcome parameter: Female Sexual Function Index (FSFI); secondary outcome parameters: Female Sexual Distress Scale (FSDS), Sexual Quality of Life-Female (SQOL-F), Sexual Interest and Desire Inventory-Female (SIDI-F), and Hamilton depression scale (HDS). RESULT(S):After oxytocin and placebo, the FSFI score increased by 26% and 31%, SQOL-F score by 144% and 125%, and SIDI-F score by 29% and 23%, respectively (repeated measures analysis of variance between groups). After oxytocin and placebo, the FSDS score decreased by 36% and 45%, respectively (repeated measures analysis of variance between groups). There was no statistically significant treatment, sequence (placebo first/second), or interaction effect. CONCLUSION(S):Long-term intranasal oxytocin and placebo administration both improved sexual function and symptoms of depression in women over time with no treatment, sequence (placebo first/second), or interaction effect. CLINICAL TRIAL REGISTRATION NUMBER:NCT02229721.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Muin DA,Wolzt M,Marculescu R,Sheikh Rezaei S,Salama M,Fuchs C,Luger A,Bragagna E,Litschauer B,Bayerle-Eder M

doi

10.1016/j.fertnstert.2015.06.010

subject

Has Abstract

pub_date

2015-09-01 00:00:00

pages

715-23.e4

issue

3

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(15)00432-X

journal_volume

104

pub_type

杂志文章,随机对照试验

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