Abstract：
OBJECTIVE:To determine whether retinoic acid (RA) can regulate the expression of interleukin (IL)-6 in human endometrial cells in a manner that might be beneficial to women with endometriosis. DESIGN:In vitro study. SETTING:Academic medical center. PATIENT(S):Patients with endometriosis and controls. INTERVENTION(S):Endometrial cell cultures were treated with RA. MAIN OUTCOME MEASURE(S):Interleukin-6 protein secretion, messenger RNA expression, and IL-6-promoter activity. RESULT(S):Using a human endometrial cell line (EM42), as well as primary stromal and epithelial endometrial cells, we demonstrated that RA suppresses IL-6 protein and messenger RNA expression in a time- and dose-dependent fashion, showing maximal effects at pharmacologically achievable blood serum concentrations (micromoles per liter). Retinoic acid specifically inhibited the activity of IL-6-promoter reporter constructs that were transiently transfected into EM42 cells. Mutational analysis of reporter constructs indicated that RA suppression of IL-6 expression was mediated, at least in part, through the nuclear factor IL-6 binding site located in the IL-6 promoter. CONCLUSION:Retinoids may play a fundamental role in altering the pathophysiology of endometriosis related to aberrant production of IL-6.
journal_name
Fertil Steriljournal_title
Fertility and sterilityauthors
Sawatsri S,Desai N,Rock JA,Sidell Ndoi
10.1016/s0015-0282(00)00483-0keywords:
subject
Has Abstractpub_date
2000-05-01 00:00:00pages
1012-9issue
5eissn
0015-0282issn
1556-5653pii
S0015-0282(00)00483-0journal_volume
73pub_type
杂志文章abstract：OBJECTIVE:To investigate the effect of vascular endothelial growth factor (VEGF) injection into the testes on spermatogenesis and apoptosis in a varicocele-induced adolescent rat model. SETTING:University hospital urology research laboratory. ANIMAL(S):Six-week-old male Wistar rats (n = 32). INTERVENTION:The rats we...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2008.06.008
更新日期：2009-05-01 00:00:00
abstract：OBJECTIVE:To analyze the effect of human papilloma virus (HPV) sperm infection on sperm parameters and in vitro fertilization (IVF) outcomes. DESIGN:Systematic review and meta-analysis. SETTING:Not applicable. PATIENTS:Men with HPV sperm infection and couples undergoing IVF. INTERVENTIONS:Searches were conducted in...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2020.01.010
更新日期：2020-05-01 00:00:00
abstract：:The presence of ovarian cysts may compromise the success of in vitro fertilization (IVF) and gamete intrafallopian transfer (GIFT). We prospectively studied 212 consecutive ovulation induction cycles in 120 patients for IVF and/or GIFT. A baseline cyst was defined as any intraovarian cystic structure greater than or e...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)54123-5
更新日期：1991-02-01 00:00:00
abstract：OBJECTIVE:To evaluate concentration of granulocyte colony-stimulating factor (G-CSF) in serum and follicular fluid (FF) at the time of oocyte retrieval and to detect expression of G-CSF and its receptor by luteinized granulosa cells (GCs). DESIGN:Collection of serum and FF at the time of oocyte retrieval. SETTING:A u...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2003.09.039
更新日期：2004-03-01 00:00:00
abstract：OBJECTIVE:To determine whether IgG subclass patterns differed between nonpregnant women, healthy pregnant women, and pregnant women with a history of recurrent miscarriage. DESIGN:Controlled clinical study. SETTING:An academic setting. PATIENT(S):Group 1 was comprised of 10 nonpregnant women, group 2 of 10 healthy p...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(01)02857-6
更新日期：2001-11-01 00:00:00
abstract：OBJECTIVE:To present the results of assisted reproductive technology (ART) cycles performed in 2004 in Canada. This is the fourth annual report of Canadian ART outcomes. DESIGN:Prospective cohort study. SETTING:Twenty-six of 26 ART centers in Canada. PATIENT(S):Couples undergoing ART treatment in Canada during 2004....
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2007.05.015
更新日期：2008-05-01 00:00:00
abstract：OBJECTIVE:To investigate c-fos and matrix metalloproteinase-9 (MMP-9) expression in the endometrium from women with or without endometriosis throughout the menstrual cycle, and to explore the correlation of c-fos expression with MMP-9 expression and 17beta-E(2) levels in serum. DESIGN:Molecular studies in human tissue...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2007.07.1386
更新日期：2008-10-01 00:00:00
abstract：OBJECTIVE:To review recent advances in understanding the role of leptin in the physiology and pathophysiology of reproduction, with a focus on relevant clinical situations. DESIGN:A MEDLINE computer search was performed to identify relevant articles. RESULT(S):Leptin, an adipocyte hormone important in regulating ener...
journal_title：Fertility and sterility
pub_type： 杂志文章,评审
doi：10.1016/s0015-0282(01)03010-2
更新日期：2002-03-01 00:00:00
abstract：OBJECTIVE:To examine the implantation potential of embryos from assisted reproductive technology cycles with low embryo production and to assess the effects of clinical variables and embryo scores (ES) on pregnancy outcome. DESIGN:Prospective clinical study. SETTING:Assisted reproductive technology unit in a tertiary...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2003.05.011
更新日期：2003-12-01 00:00:00
abstract：OBJECTIVE:To evaluate the effectiveness of L-carnitine (LC) or L-acetyl-carnitine (LAC) or combined LC and LAC treatment in improving semen kinetic parameters and the total oxyradical scavenging capacity in semen. DESIGN:Placebo-controlled, double-blind, randomized trial. SETTING:Andrology unit, Department of Interna...
journal_title：Fertility and sterility
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.fertnstert.2005.03.064
更新日期：2005-09-01 00:00:00
abstract：:Genetic factors, especially numerical chromosome anomalies, play an important role in embryonic loss. Because somatic cell analysis cannot assess the risk of errors arising de novo during germ cell maturation, we investigated whether the male gametes from couples with habitual abortion carry a higher rate of anomalies...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)54505-1
更新日期：1991-08-01 00:00:00
abstract：:Testosterone and 19-nortestosterone derivatives were evaluated in a developmental scheme designed to identify competitive progesterone antagonists having abortifacient activity. Compounds that displayed significant binding to the rabbit uterine progesterone receptor were followed in biologic tests for progestational, ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)44003-3
更新日期：1979-05-01 00:00:00
abstract：:In this study, acrosin activity and hyaluronic acid binding were compared in sperm from men with spinal cord injury versus sperm from healthy controls. The results showed statistically significantly lower acrosin activity and statistically significantly lower hyaluronic acid binding in spinal cord injured patients com...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2010.01.015
更新日期：2010-10-01 00:00:00
abstract：:A liquefraction factor from normal human seminal plasma was purified by cation and anion exchange chromatography. It is nondialyzable, heat-labile, and has many properties in common with the seminal protease "chymotrypsin-like enzyme." Its lytic effect is most distinctly observed in abnormal semen that is semisolid or...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)41471-8
更新日期：1975-11-01 00:00:00
abstract：OBJECTIVE:To investigate PPARGC1A promoter methylation and mitochondria DNA (mtDNA) content in the leukocytes of women with polycystic ovary syndrome (PCOS) and analyze the relationship between these indices and metabolic risk for women with PCOS. DESIGN:Cross-sectional study. SETTING:University hospital. PATIENT(S)...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2016.10.039
更新日期：2017-02-01 00:00:00
abstract：:The results of reinsemination of 150 morphologically mature oocytes that failed to fertilize within 15 to 20 hours after initial insemination were evaluated. Only 41 oocytes (27.3%) were fertilized after reinsemination, which is significantly lower than the percentage obtained after initial insemination (74%). However...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)49097-7
更新日期：1986-01-01 00:00:00
abstract：OBJECTIVE:To develop and test a simple, feasible approach to improve spindle assembly and developmental competence of human in vitro matured oocytes by parthenogenetic activation in maturation medium. DESIGN:Prospective, randomized study. SETTING:University research laboratory-based assisted reproductive technology l...
journal_title：Fertility and sterility
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.fertnstert.2011.04.077
更新日期：2011-07-01 00:00:00
abstract：OBJECTIVE:To assess whether provision of an educational DVD was more effective in increasing the uptake of elective single embryo transfers (eSET) than an educational brochure in an IVF population. DESIGN:Randomized controlled trial. SETTING:Private IVF clinic. PATIENT(S):One hundred thirty-one couples starting thei...
journal_title：Fertility and sterility
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.fertnstert.2009.03.080
更新日期：2010-07-01 00:00:00
abstract：:Well-designed and -conducted clinical trials are needed to further advance the field for reproductive medicine. However, current reporting of outcomes of trials is ambiguous and disparate. In this review it is offered that the preferred outcome for clinical trials in reproductive medicine should be live birth. Multipl...
journal_title：Fertility and sterility
pub_type： 杂志文章,评审
doi：10.1016/j.fertnstert.2014.03.026
更新日期：2014-05-01 00:00:00
abstract：OBJECTIVE:To measure serum anti-Müllerian hormone (AMH) during different phases of the menstrual cycle and to correlate the measurements with ovarian response and clinical-pregnancy rates in intracytoplasmic sperm injection cycles. DESIGN:Prospective cohort study. SETTING:University IVF unit. PATIENT(S):Thirty-three...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2007.05.040
更新日期：2008-06-01 00:00:00
abstract：OBJECTIVE:To test for an association between DNA fragmentation and head shape at high magnification in fresh motile spermatozoa. DESIGN:Observational study. SETTING:Academic tertiary care center. PATIENT(S):A total of 60 men in our assisted reproductive program. INTERVENTION(S):Quantifying sperm head shape using el...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2013.01.100
更新日期：2013-05-01 00:00:00
abstract：:This report describes the historical experience of our laboratory in the handling and processing of epididymal sperm from men with congenital absence of the vas deferens. Three different methods of sperm preparation were used: swim-up or resuspension in the first group of patients treated, mini-Percoll in the second g...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)55031-6
更新日期：1992-05-01 00:00:00
abstract：OBJECTIVE:To investigate the influence of folic acid supplementation on the follicular fluid concentrations of folate and total homocysteine and their relationship to the diameter of the follicle. DESIGN:Observational study. SETTING:Tertiary referral fertility clinic at the Erasmus MC, University Medical Center, Rott...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2007.06.036
更新日期：2008-06-01 00:00:00
abstract：OBJECTIVE:To determine the efficacy of combined l-carnitine and l-acetyl-carnitine therapy in infertile males with oligo-astheno-teratozoospermia. DESIGN:Placebo-controlled double-blind randomized trial. SETTING:University tertiary referral center. PATIENT(S):Sixty infertile patients (aged 20-40 years) with the foll...
journal_title：Fertility and sterility
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/j.fertnstert.2003.10.034
更新日期：2004-06-01 00:00:00
abstract：OBJECTIVE:To compare the rate of ectopic pregnancy (EP) with fresh versus frozen blastocyst transfer in our program during the same time period. DESIGN:Retrospective analysis. SETTING:University IVF program. PATIENT(S):Women who achieved a clinical pregnancy after IVF between 1998 and 2005. INTERVENTION(S):In our p...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2006.12.005
更新日期：2007-09-01 00:00:00
abstract：OBJECTIVE:To examine the relationship between sperm chromatin defects, evaluated by the flow cytometric (FCM) sperm chromatin structure assay (SCSA), and the probability of a pregnancy in a menstrual cycle (fecundability). DESIGN:Follow-up study. SETTING:The Section of Toxicology and Biomedical Sciences, ENEA Casacci...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(99)00462-8
更新日期：2000-01-01 00:00:00
abstract：OBJECTIVE:To review the effectiveness of rectal probe electroejaculation in terms of pregnancy in treatment of anejaculatory males due to spinal cord injury. The characteristics of electroejaculates also are examined. DATA IDENTIFICATION:All English language studies reporting pregnancies as a result of electroejaculat...
journal_title：Fertility and sterility
pub_type： 杂志文章,评审
doi：
更新日期：1995-07-01 00:00:00
abstract：:Five patients with primary infertility and secondary amenorrhea who did not respond to clomiphene with a gonadotropin or estrogen surge were treated with 500 mug of luteinizing hormone, follicle-stimulating hormone-releasing hormone (LH-RH), self-administered subcutaneously every 8 hours for 14 days. Of four patients ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)41890-x
更新日期：1976-06-01 00:00:00
abstract：:Detection of bacteria with molecular techniques has enabled the study of low biomass microbiomes in tissues and organs previously considered sterile, such as the endometrium. Subsequently, an abnormal endometrial microbiota has been associated with implantation failure, pregnancy loss, and other gynecological and obst...
journal_title：Fertility and sterility
pub_type： 杂志文章,评审
doi：10.1016/j.fertnstert.2017.05.034
更新日期：2017-07-01 00:00:00
abstract：OBJECTIVE:To investigate whether sphingosine-1-phosphate (S1P), an apoptosis-inhibitor, would be able to protect ovarian follicles from chemotherapy-induced cell death in vivo. DESIGN:Animal study. SETTING:Academic medical center. ANIMAL(S):Twenty female mice. INTERVENTION(S):Twenty mice were randomly assigned into...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2006.06.020
更新日期：2007-01-01 00:00:00
