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No increase in arteriolosclerotic retinopathy or activity in tests for circulating immune complexes 5 years after vasectomy.

Abstract：

:On the basis of studies in monkeys, the hypothesis has been proposed that vasectomy induces the formation of circulating immune complexes (CICs), which--via activation of the complement system--may result in immune injury of the endothelium and thereby exacerbate atherosclerosis; the same mechanism has been suggested to cause retinal arteriolar changes in vasectomized men. We compared 46 men, 5 years after vasectomy, with 46 age-matched control subjects and found no difference in the distribution of arteriolosclerotic retinopathy gradings evaluated by ophthalmoscopy and fundus photography. Blood samples from the two groups were collected and handled identically, and no significant difference in activity was found in four different tests for CICs and two tests for split products of complement factor C3. Thus, the results do not support the hypothesis that changes mediated by CICs occur in vessels after human vasectomy.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Linnet L,Møller NP,Bernth-Petersen P,Ehlers N,Brandslund I,Svehag SE

subject

Has Abstract

pub_date

1982-06-01 00:00:00

pages

798-806

issue

6

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(16)46341-7

journal_volume

37

pub_type

杂志文章

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