Levels of androgens and danazol metabolites in serum during danazol therapy.

Abstract:

:Thirteen women who had endometriosis were treated with danazol (300 to 400 mg/d). Levels of androgens and danazol metabolites in serum and the influences of danazol metabolites on the assays for serum androgen were investigated during danazol therapy. Serum DHEAS significantly increased (P < 0.05), but serum DHEA slightly decreased. Serum T levels, measured by direct assay, were markedly elevated. However, measured after HPLC separation, the T levels in serum were significantly decreased (P < 0.05). There were considerable cross-reactions between danazol metabolites and androgens (T, DHEA, and A) in RIA. Purification of androgens using column chromatography was necessary to measure serum androgens precisely.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Murakami K,Nakagawa T,Yamashiro G,Araki K,Akasofu K

subject

Has Abstract

pub_date

1993-07-01 00:00:00

pages

179-81

issue

1

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(16)56060-9

journal_volume

60

pub_type

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