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The CC-allele of the PvuII polymorphic variant in intron 1 of the α-estrogen receptor gene is significantly more prevalent among infertile women at risk of premature ovarian aging.

Abstract：

OBJECTIVE:To study the distribution of a set of polymorphic alleles of genes encoding key regulators of the menstrual cycle in cohorts of women with different levels of fertility. DESIGN:Prospective cohort study. SETTING:University hospital. PATIENT(S):Two hundred fertile women, who reported to have conceived within 3 months, 348 women with ongoing menstrual cycles suffering of infertility, and 48 infertile women diagnosed with infertility and premature ovarian failure (POF). INTERVENTION(S):Eleven polymorphisms of genes with known associations with surrogate parameters of female ovarian function were analyzed. MAIN OUTCOME MEASURE(S):The prevalence of polymorphic alleles in the three distinct cohorts after adjustment for age. RESULT(S):The distributions of the allelic variants were compared with the fertility status of the recruited women. Using age-adjusted logistic regression analysis and the Bonferroni correction for multiple corrections, the CC-allele of the PvuII polymorphic variant in intron 1 of the ESR1 gene was twice as prevalent among women suffering from infertility. None of the other polymorphisms were distributed differently among the three cohorts. CONCLUSION(S):The ESR1-PvuII polymorphism emerges as a potential candidate for the early prediction of infertility due to premature ovarian aging.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

M'Rabet N,Moffat R,Helbling S,Kaech A,Zhang H,de Geyter C

doi

10.1016/j.fertnstert.2012.05.048

subject

Has Abstract

pub_date

2012-10-01 00:00:00

pages

965-72.e1-5

issue

4

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(12)00602-4

journal_volume

98

pub_type

杂志文章

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