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Role of follicle-stimulating hormone receptor Ser680Asn polymorphism in the efficacy of follicle-stimulating hormone.

Abstract：

OBJECTIVE:To evaluate the association between FSH efficacy and FSHR alleles. DESIGN:Retrospective study. SETTING:University-based fertility unit and a private center for biomedical research. PATIENT(S):One hundred two women with ovarian function who were undergoing controlled ovarian stimulation (COS). Women were categorized as poor responders (< or =3 ovarian follicles at the end of the cycle) or normal responders (>3 follicles). INTERVENTION(S):Daily administration of exogenous FSH. MAIN OUTCOME MEASURE(S):Number of good or poor responders. RESULT(S):The allele frequency and genotype distribution of the Ser680Asn marker differed significantly between groups. Cycle cancellations were increased (21%) among women who were homozygous for Ser680 compared with Ser/Asn and Asn/Asn patients, and 36% of poor-responders were homozygous for Ser680. CONCLUSION(S):The results support a role for FSHR gene in COS outcome. However, the weight of this factor is probably low. The Ser680 allele may act in concert with other environmental and genetic factors that contribute to FSH efficacy.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

de Castro F,Ruiz R,Montoro L,Pérez-Hernández D,Sánchez-Casas Padilla E,Real LM,Ruiz A

doi

10.1016/s0015-0282(03)00795-7

keywords:

subject

Has Abstract

pub_date

2003-09-01 00:00:00

pages

571-6

issue

3

eissn

0015-0282

issn

1556-5653

pii

S0015028203007957

journal_volume

80

pub_type

杂志文章

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