当前位置： SCI文献检索 > FERTILITY AND STERILITY期刊下所有文献 > Serum bioactive and immunoreactive follicle-stimulating hormone in oligozoospermic and azoospermic men: application of a modified granulosa cell bioassay.

Serum bioactive and immunoreactive follicle-stimulating hormone in oligozoospermic and azoospermic men: application of a modified granulosa cell bioassay.

Abstract：

:Serum follicle-stimulating hormone (FSH) levels measured by radioimmunoassay (RIA) usually correlate well with the rate of spermatogenesis. However, in certain cases this correlation does not exist. The purpose of this study was to establish a reliable bioassay of FSH for the andrological clinic. Follicle-stimulating hormone was measured by both standard RIA and bioassay in 98 men subgrouped into normospermic, oligospermic, and azoospermic. Bioactivity of FSH was determined using in vitro cultures of granulosa cells utilizing progesterone measurements for assessing FSH activity. Results of FSH levels obtained by both methods correlated well (r = 0.55, P less than 0.01) within themselves, and both correlated negatively and significantly with sperm concentration. The ratio between bioactivity and immunoreactivity of FSH did not correlate with sperm density. Thus, the decrease in sperm concentration and other sperm variables resulting from a germinal epithelial dysfunction was not mediated or associated with low biological activity of FSH. The application of this method can be of clinical value in cases where a discrepancy is found between serum RIA-FSH levels and sperm quality.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Matzkin H,Homonnai ZT,Galiani D,Paz G,Dekel N

doi

10.1016/s0015-0282(16)53469-4

subject

Has Abstract

pub_date

1990-04-01 00:00:00

pages

709-14

issue

4

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(16)53469-4

journal_volume

53

pub_type

杂志文章

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