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Adiponectin and its receptors modulate granulosa cell and cumulus cell functions, fertility, and early embryo development in the mouse and human.

Abstract：

OBJECTIVE:To study the expression and function of adiponectin and its receptors in mouse and human follicle cells and in early embryo development. DESIGN:Whole ovaries, granulosa cells, and cumulus-oocyte complexes isolated from immature mice before and during hormone-induced ovulation were used to analyze the expression of adiponectin, its receptors, and ovulation-related genes; human cumulus cells and granulosa cells were isolated from patients undergoing in vitro fertilization (IVF) procedures. SETTING:Multicenter. PATIENT(S):Women in IVF programs in Japan and the United States. INTERVENTION(S):None. MAIN OUTCOME MEASURE(S):Expression of adiponectin receptors and fertility. RESULT(S):Adiponectin expression is absent/low in mouse and human granulosa cells and cumulus cells. Adiponectin receptors are hormonally regulated in mouse granulosa and cumulus cells in vivo and in culture. Adiponectin differentially alters the expression of Adipor1/Adipor2 as well as genes related to steroidogenesis, ovulation, and apoptosis in cumulus cells versus granulosa cells. Adiponectin enhances oocyte maturation and early embryo development in mouse and human IVF procedures. CONCLUSION(S):Adiponectin can modulate not only follicle growth but also embryo development in mice and humans.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Richards JS,Liu Z,Kawai T,Tabata K,Watanabe H,Suresh D,Kuo FT,Pisarska MD,Shimada M

doi

10.1016/j.fertnstert.2012.04.050

subject

Has Abstract

pub_date

2012-08-01 00:00:00

pages

471-9.e1

issue

2

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(12)00536-5

journal_volume

98

pub_type

杂志文章,多中心研究

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