Number of biopsied trophectoderm cells is likely to affect the implantation potential of blastocysts with poor trophectoderm quality.

Abstract:

OBJECTIVE:To evaluate whether the developmental potential of the blastocyst is affected by the number of trophectoderm (TE) cells biopsied in preimplantation genetic diagnosis (PGD) cycles. DESIGN:Retrospective study. SETTING:University-affiliated center. PATIENT(S):Women underwent PGD cycles of blastocyst biopsy and fluorescence in situ hybridization analysis. INTERVENTION(S):Not applicable. MAIN OUTCOME MEASURE(S):Biopsied TE cell number of blastocysts, survival, and implantation rates. RESULT(S):The biopsied TE cell number was affected by the TE quality and experience of different embryologists. The diagnostic efficiency increased when from one to five cells were biopsied (86.7%, 91.7%%, 96.0%, 96.8%, to 98.7%) and was maximized when more than six cells were biopsied. To compare the clinical efficiencies, blastocysts were divided into four groups according to biopsied TE cell number: 1-5, 6-10, 11-15, and 16-41. For the blastocysts with grade A TE score, no significant difference was observed in the survival and implantation rates among the four groups. For the blastocysts with grades B and C TE scores, the survival rates showed no significant differences among the four groups, but a significant decreasing trend in implantation rates was observed with increasing biopsied TE cell number. CONCLUSION(S):The implantation potential is negatively affected by the biopsied TE cell number in blastocysts with poor TE morphological score.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Zhang S,Luo K,Cheng D,Tan Y,Lu C,He H,Gu Y,Lu G,Gong F,Lin G

doi

10.1016/j.fertnstert.2016.01.011

subject

Has Abstract

pub_date

2016-05-01 00:00:00

pages

1222-1227.e4

issue

5

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(16)00046-7

journal_volume

105

pub_type

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