Intrauterine insemination-ready versus conventional semen cryopreservation for donor insemination: a comparison of retrospective results and a prospective, randomized trial.

Abstract:

OBJECTIVE:To compare fecundity rates following intrauterine insemination (IUI) with donor sperm frozen conventionally versus an IUI-ready preparation. DESIGN:Both retrospective results and a prospective, randomized study where recipients were assigned to one of two sperm cryopreservation methods in each cycle of intrauterine insemination are reported. SETTING:University-based infertility practice, affiliated private practices, and andrology laboratory. PATIENT(S):Women desiring therapeutic insemination in an effort to establish pregnancy. INTERVENTION(S):Intrauterine insemination with donor sperm frozen conventionally or by an IUI-ready protocol. MAIN OUTCOME MEASURE(S):Cycle fecundity in donor IUI recipients. RESULT(S):In a retrospective analysis involving 642 inseminations in 209 recipients, 79 pregnancies were recorded for an overall pregnancy rate of 12.3% per insemination (or cycle): 11.3% with IUI-ready sperm and 13.9% with conventionally preserved sperm. In a follow-up prospective, randomized study, the pregnancy rate for IUI-ready sperm preparations was 36% per cycle (14 of 39) whereas that for conventionally preserved sperm was 19.6% per cycle (9 of 46). Thirteen of the 23 pregnancies occurred in the first study cycle of insemination; only two pregnancies were observed in patients undergoing more than four cycles of insemination. CONCLUSION(S):Cycle fecundity for IUI-ready donor sperm is equivalent to conventional cryopreserved sperm based on both prospective and retrospective assessments.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Wolf DP,Patton PE,Burry KA,Kaplan PF

doi

10.1016/s0015-0282(01)01857-x

keywords:

subject

Has Abstract

pub_date

2001-07-01 00:00:00

pages

181-5

issue

1

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(01)01857-X

journal_volume

76

pub_type

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