The oncofetal protein IMP3: a novel biomarker and triage tool for premalignant atypical endometriotic lesions.

Abstract:

OBJECTIVE:To determine whether the oncofetal protein IMP3 is detectable in endometriomas with or without histological atypia and whether IMP3 staining can be used as a triage tool to identify foci of atypical endometriosis in doubtful cases. DESIGN:Retrospective study. SETTING:Academic department and referral center for endometriosis. PATIENT(S):A consecutive series of 516 women who underwent excision of 874 endometriomas. INTERVENTION(S):Histological review by three expert pathologists and immunohistochemical staining for IMP3. MAIN OUTCOME MEASURE(S):Test performance of IMP3 immunohistochemistry versus first-round histology. RESULT(S):The prevalence of atypical endometriosis was 1.7% (95% confidence interval [CI], 0.9%-3.3%) based on the number of women and 1.0% (95% CI, 0.5%-1.9%) based on the number of cysts. Three cases of atypical endometriosis were identified at first-round histological examination. Immunohistochemistry detected seven of the eight cases diagnosed as preneoplastic atypia at second-round histology and one case diagnosed as reactive atypia at second-round histology. The sensitivity of first-round histology was 33.3%, compared with 88.9% of IMP3 immunohistochemistry. CONCLUSION(S):Immunohistochemical staining for IMP3 expression is a simple, inexpensive, and sensitive test that can be used in routine clinical practice as a triage tool to discriminate between cytological/structural atypia and confounding benign conditions.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Vercellini P,Cribiù FM,Del Gobbo A,Carcangiu ML,Somigliana E,Bòsari S

doi

10.1016/j.fertnstert.2013.02.002

subject

Has Abstract

pub_date

2013-06-01 00:00:00

pages

1974-9

issue

7

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(13)00255-0

journal_volume

99

pub_type

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