The oncofetal protein IMP3: a novel biomarker and triage tool for premalignant atypical endometriotic lesions.


OBJECTIVE:To determine whether the oncofetal protein IMP3 is detectable in endometriomas with or without histological atypia and whether IMP3 staining can be used as a triage tool to identify foci of atypical endometriosis in doubtful cases. DESIGN:Retrospective study. SETTING:Academic department and referral center for endometriosis. PATIENT(S):A consecutive series of 516 women who underwent excision of 874 endometriomas. INTERVENTION(S):Histological review by three expert pathologists and immunohistochemical staining for IMP3. MAIN OUTCOME MEASURE(S):Test performance of IMP3 immunohistochemistry versus first-round histology. RESULT(S):The prevalence of atypical endometriosis was 1.7% (95% confidence interval [CI], 0.9%-3.3%) based on the number of women and 1.0% (95% CI, 0.5%-1.9%) based on the number of cysts. Three cases of atypical endometriosis were identified at first-round histological examination. Immunohistochemistry detected seven of the eight cases diagnosed as preneoplastic atypia at second-round histology and one case diagnosed as reactive atypia at second-round histology. The sensitivity of first-round histology was 33.3%, compared with 88.9% of IMP3 immunohistochemistry. CONCLUSION(S):Immunohistochemical staining for IMP3 expression is a simple, inexpensive, and sensitive test that can be used in routine clinical practice as a triage tool to discriminate between cytological/structural atypia and confounding benign conditions.


Fertil Steril


Fertility and sterility


Vercellini P,Cribiù FM,Del Gobbo A,Carcangiu ML,Somigliana E,Bòsari S




Has Abstract


2013-06-01 00:00:00














  • The Stein-Leventhal syndrome: a neuropituitary disorder.

    abstract::Hypothalamic and pituitary gonadotropin function and responsiveness in four patients with well-documented Stein-Leventhal syndrome were studied. All patients were of reproductive age and had had menstrual disorders since menarche. Estrogen production was assessed by measuring the circulating levels of immunoreactive e...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Scaglia H,Medina M,Gual C,Cabeza M,Pérez-Palacios G

    更新日期:1976-03-01 00:00:00

  • Plasminogen activator inhibitor 1 and miscarriage after metformin treatment and laparoscopic ovarian drilling in patients with polycystic ovary syndrome.

    abstract::In women with polycystic ovary syndrome, metformin administration, not laparoscopic ovarian drilling, reduces plasminogen activator inhibitor 1 (PAI-1) activity. The lack of a decrease in PAI-1 activity is related to a high risk for miscarriage. ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Palomba S,Orio F Jr,Falbo A,Russo T,Tolino A,Zullo F

    更新日期:2005-09-01 00:00:00

  • Superoxide anion in human semen related to seminal parameters and clinical aspects.

    abstract:OBJECTIVE:To study the possible presence of extracellular superoxide anion (O2-) in untreated semen of normal and pathological subjects and to determine the possible relationship between superoxide anion levels, number of seminal leukocytes (WBCs) and seminal parameters. PATIENTS:Semen samples were analyzed from ferti...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Mazzilli F,Rossi T,Marchesini M,Ronconi C,Dondero F

    更新日期:1994-10-01 00:00:00

  • The use of transvaginal color flow imaging after in vitro fertilization to identify optimum uterine conditions before embryo transfer.

    abstract:OBJECTIVE:To assess whether a measure of uterine blood flow impedance (the pulsatility index, PI) as determined by transvaginal ultrasonography with color blood flow imaging, may be used to assess endometrial receptivity immediately before the time of embryo transfer (ET) after assisted conception. DESIGN:A prospectiv...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Steer CV,Campbell S,Tan SL,Crayford T,Mills C,Mason BA,Collins WP

    更新日期:1992-02-01 00:00:00

  • Ultrasonographer experience does not impact outcomes following ultrasound-guided embryo transfer.

    abstract:OBJECTIVE:To determine the effect of sonographer experience during ultrasound guided embryo transfer on pregnancy outcomes. DESIGN:Retrospective chart review. SETTING:A university-based academic practice. PATIENT(S):A total of 319 women who underwent in vitro fertilization and embryo transfer (IVF-ET) from the site-...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Harris ID,Styer AK,Petrozza JC

    更新日期:2009-09-01 00:00:00

  • Efficacy of tibolone as "add-back therapy" in conjunction with a gonadotropin-releasing hormone analogue in the treatment of uterine fibroids.

    abstract:OBJECTIVE:To assess the efficacy of tibolone add-back therapy with Goserelin treatment of uterine fibroids. DESIGN:Randomized placebo-controlled study. SETTING:Gynecology department of an inner-city teaching hospital. PATIENT(S):Seventy-five women of reproductive age with uterine fibroids. INTERVENTION(S):All women...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,随机对照试验


    authors: Morris EP,Rymer J,Robinson J,Fogelman I

    更新日期:2008-02-01 00:00:00

  • Effects of danazol, gonadotropin-releasing hormone agonist, and estrogen/progestogen combination on experimental endometriosis in the ovariectomized rat.

    abstract::Direct effects of a gonadotropin-releasing hormone agonist (GnRHa), danazol, or estrogen/progestogen (E/P) on experimental endometriosis were evaluated in castrated female rats. Endometrial explants decreased in size following castration, but there was no further change in the treatment groups. Histologic examination ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Henig I,Rawlins RG,Weinrib HP,Dmowski WP

    更新日期:1988-02-01 00:00:00

  • Controlled ovarian hyperstimulation and transvaginal intratubal insemination as an alternative to gamete intrafallopian transfer.

    abstract:OBJECTIVE:To evaluate the efficacy of controlled ovarian hyperstimulation (COH) followed by intratubal insemination in the treatment of infertility. DESIGN:Retrospective analysis of 179 intratubal insemination trials in 78 women over a 48-month period. SETTING:Reproductive endocrinology practice. PATIENTS:Seventy-ei...

    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章


    authors: Toaff ME,Gross ST,Lev-Toaff AS

    更新日期:1995-10-01 00:00:00

  • Inhibitory effects of danazol on steroidogenesis in cultured human granulosa cells.

    abstract::The effect of danazol on steroidogenesis in cultured human granulosa cells was studied. Granulosa cells obtained from antral follicles in the mid to late follicular phase were cultured for 2 to 6 days. Danazol (0.1 to 5 micrograms/ml) and human chorionic gonadotropin (hCG, 10 IU/ml), alone or in combination, were adde...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Olsson JH,Hillensjö T,Nilsson L

    更新日期:1986-08-01 00:00:00

  • European view of subspecialty training on behalf of the European Society of Human Reproduction and Embryology (ESHRE).

    abstract::Specialist training in reproductive medicine within Europe continues to evolve. Recent revisions, updates, and initiatives have helped to refine the core educational needs for the specialist trainee. ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,评审


    authors: Calhaz-Jorge C,Feki A,Farquharson R

    更新日期:2015-07-01 00:00:00

  • BRCA carriers' thoughts on risk management in relation to preimplantation genetic diagnosis and childbearing: when too many choices are just as difficult as none.

    abstract::Women with a BRCA mutation have unique concerns about childbearing and future fertility. In a focus group conducted among unaffected carriers, the majority of women held positive attitudes toward preimplantation genetic diagnosis to reduce transmission to future offspring and further identified unmet needs for educati...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Quinn GP,Vadaparampil ST,Tollin S,Miree CA,Murphy D,Bower B,Silva C

    更新日期:2010-11-01 00:00:00

  • Round spermatid nucleus injection (ROSNI).

    abstract::This Committee Opinion reviews the unresolved issues and experimental nature associated with the procedure and its limited success rates. ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,评审


    authors: Practice Committee of American Society for Reproductive Medicine.,Practice Committee of Society for Assisted Reproductive Technology.

    更新日期:2008-11-01 00:00:00

  • Human serum and follicular fluid stimulate hyperactivation of human spermatozoa after preincubation.

    abstract:OBJECTIVE:To test the effects of steroid-containing media such as follicular fluid (FF) and serum and of steroid-free but human protein-rich medium on hyperactivation (HA) of human spermatozoa with and without a preincubation period. DESIGN:Analysis of HA using a computer-aided sperm analysis system. SETTING:Academic...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Kulin S,Bastiaans BA,Hollanders HM,Janssen HJ,Goverde HJ

    更新日期:1994-12-01 00:00:00

  • Relationship of epididymal sperm antibodies to their in vitro fertilization capacity in men with congenital absence of the vas deferens.

    abstract:OBJECTIVES:To test, using the immunobead binding technique, for the presence of antisperm antibodies on epididymal sperm, in epididymal fluid, and in serum of men with congenital absence of the vas deferens. To evaluate the in vitro fertilization (IVF) capacity of human epididymal sperm in the presence of antisperm ant...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Patrizio P,Silber SJ,Ord T,Moretti-Rojas I,Asch RH

    更新日期:1992-11-01 00:00:00

  • Ovarian responses to menopausal gonadotropins in groups of patients with differing basal growth hormone levels.

    abstract:OBJECTIVE:To investigate the relationship between endogenous serum levels of human growth hormone (hGH) and ovarian response to human menopausal gonadotropins (hMG). DESIGN:Retrospective analysis of patient response to hMG. SETTING:Center for assisted reproductive technology. PATIENTS:Eighty women who had undergone ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Stone BA,Marrs RP

    更新日期:1992-07-01 00:00:00

  • Distribution of type IV collagen subtypes in human testes and their association with spermatogenesis.

    abstract:OBJECTIVE:To evaluate the expression of type IV collagen [alpha1(IV) to alpha6(IV)] in testes and the association with spermatogenesis. DESIGN:Retrospective immunohistochemical study. SETTING:Division of Urology, Department of Organs Therapeutics, Faculty of Medicine, in a university hospital. PATIENT(S):Testicular ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Dobashi M,Fujisawa M,Naito I,Yamazaki T,Okada H,Kamidono S

    更新日期:2003-09-01 00:00:00

  • Daily levels of salivary progesterone during menstrual cycle in adolescent girls.

    abstract:OBJECTIVE:To study the daily levels of salivary progesterone (P) during the menstrual cycles of adolescent girls 14 to 19 years of age and the occurrence of anovulations and defective luteal phases. DESIGN:The salivary P levels were analyzed by radioimmunoassay from three age groups of girls (n = 65) and compared with...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Vuorento T,Huhtaniemi I

    更新日期:1992-10-01 00:00:00

  • Raw and test-thaw semen parameters after cryopreservation among men with newly diagnosed cancer.

    abstract:OBJECTIVE:To characterize sperm parameters from thawed semen samples of men with different cancers who cryopreserved semen before oncologic therapy. DESIGN:Retrospective cohort study. SETTING:Tertiary academic medical center. PATIENT(S):1,010 semen samples collected between 1994 to 2010. INTERVENTION(S):None. MAIN...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Hotaling JM,Lopushnyan NA,Davenport M,Christensen H,Pagel ER,Muller CH,Walsh TJ

    更新日期:2013-02-01 00:00:00

  • Decreased expression of the heat shock protein hsp70-2 is associated with the pathogenesis of male infertility.

    abstract:OBJECTIVE:To examine the expression of the heat shock protein hsp70-2, and the possible relationship with the pathogenesis of male infertility. DESIGN:Prospective study. SETTING:Reproductive testing laboratory in a university hospital. PATIENT(S):Men undergoing testicular biopsy during an investigation of subfertili...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Feng HL,Sandlow JI,Sparks AE

    更新日期:2001-12-01 00:00:00

  • Introduction: An update on bone metabolism and osteoporosis.

    abstract::Osteoporosis continues to be a major public health challenge in both women and men. There are more than 2 million low-impact fractures in the United States every year, 39% of which occur in men. The mortality rate in the first year after hip fracture is estimated at 20% to 25% in women and is even higher in men. The g...

    journal_title:Fertility and sterility



    authors: Schlaff WD

    更新日期:2019-11-01 00:00:00

  • Total acrosin activity correlates with fertility potential after fertilization in vitro.

    abstract:OBJECTIVE:To evaluate the possible relationship between total acrosin activity in spermatozoa and fertility potential after fertilization in vitro. DESIGN:Total acrosin activity of spermatozoa was measured in 101 in vitro fertilization (IVF) cases by an observer unaware of fertilization and cleavage results. SETTING:...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Tummon IS,Yuzpe AA,Daniel SA,Deutsch A

    更新日期:1991-11-01 00:00:00

  • An approach to noninvasive delivery, biodistribution, and fertility control potential evaluation of the Cuproferrogel iron oxide-copper-styrene maleic anhydride-dimethyl sulphoxide in the female.

    abstract::Under guidance of an external pulsed magnetic field the Cuproferrogel iron oxide-copper-styrene maleic anhydride-dimethyl sulphoxide delivered into the rat/rabbit oviduct resulted in oocytes with granulated cytoplasm, zona enlargement, membrane disintegration, and finally loss of viability in 72 hours. Also, the perce...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Jha R,Jha PK,Rana SV,Guha SK

    更新日期:2010-12-01 00:00:00

  • Early prediction of ovarian multifollicular response during ovulation induction in patients with polycystic ovary syndrome.

    abstract:OBJECTIVE:To examine the association between the midfollicular FSH-LH ratio and the number of follicles, and the multifollicular ovarian response to gonadotropin stimulation in patients with polycystic ovary syndrome (PCOS) with normal basal LH and FSH levels. SUBJECT(S):Eighteen patients who had an abandoned treatmen...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Farhi J,Jacobs HS

    更新日期:1997-03-01 00:00:00

  • Ovarian reserve, response to gonadotropins, and oocyte maturity in women with malignancy.

    abstract:OBJECTIVE:To study the ovarian reserve, ovarian response to gonadotropins, and oocyte maturity in women with cancer undergoing in vitro fertilization (IVF) before chemotherapy or radiotherapy. DESIGN:Case-control study. SETTING:University teaching hospital. PATIENT(S):We evaluated all women with malignancy who under...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Das M,Shehata F,Moria A,Holzer H,Son WY,Tulandi T

    更新日期:2011-07-01 00:00:00

  • The nitrofurans as sperm-immobilizing agents, their tissue toxicity, and their clinical application in vasectomy.

    abstract::Nitrofurantoin sodium and nitorfurazone, in certain critical concentrations, have the ability to immobilize spermatozoa. In this study, this effect was consisitent with both 5:1, and 10:1 dilutions. Histologic examination of the effects of these drugs as intraoperative vas irrigants revealed no apparent tissue toxicit...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Albert PS,Salerno RG,Kapoor SN,Davis JE

    更新日期:1975-06-01 00:00:00

  • Preclinical abortions and endometriosis.

    abstract::A single human chorionic gonadotropin determination was performed in 786 infertile women during the late luteal phase to determine the frequencies of preclinical abortions and whether the frequency was increased in women with endometriosis. Thirty-seven pregnancies (4.7% of cycles) were identified, of which six were c...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Pittaway DE,Ellington CP,Klimek M

    更新日期:1988-02-01 00:00:00

  • Factors affecting sperm motility. IV. Incubation of human semen with caffeine, kallikrein, and other metabolically active compounds.

    abstract::The effect of six metabolically active compounds, namely caffeine, kallikrein, cyclic adenosine 3':5'-monophosphate, prostaglandin E, triiodothyronine, and insulin on spermatozoal motility was investigated. Hypokinetic and normokinetic semen specimens from fertile and infertile patients were incubated with various con...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Makler A,Makler E,Itzkovitz J,Brandes JM

    更新日期:1980-06-01 00:00:00

  • Laparoscopic bipolar coagulation of uterine vessels: a new method for treating symptomatic fibroids.

    abstract:OBJECTIVE:To evaluate the effects of laparoscopic bipolar coagulation of uterine vessels in treating symptomatic fibroids. DESIGN:Prospective clinical study. SETTING:University-affiliated tertiary referral center. PATIENT(S):Eighty-seven women with symptomatic fibroids warranting surgical treatment and wanting to re...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Liu WM,Ng HT,Wu YC,Yen YK,Yuan CC

    更新日期:2001-02-01 00:00:00

  • Clinical studies with d-Trp 6-luteinizing hormone-releasing hormone in anovulatory women.

    abstract::Nine anovulatory patients with hypothalamic-pituitary dysfunction were treated with d-Trp6-luteinizing hormone-releasing hormone, an analog with far greater gonadotropin-releasing activity than luteinizing hormone-releasing hormone. Four of eight patients, who were formerly unsuccessfully treated with clomiphene, huma...

    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章


    authors: Jaramillo CJ,Charro-Salgado A,Peréz-Infante V,del Campo GL,Botella-Llusiá J,Coy DH,Schally AV

    更新日期:1978-04-01 00:00:00

  • Absence of block to polyspermy at the human oolemma.

    abstract:OBJECTIVE:To study the fusiogenic ability of human spermatozoa and oocytes. DESIGN:Retrospective study of 3,027 oocytes included in a program of subzonal insemination (SUZI). SETTING:Assisted fertilization program in an academic research environment. PATIENT(S):Couples with characterized male factor infertility or p...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Wolf JP,Ducot B,Aymar C,Rodrigues D,Desjardin S,Jardin A,Jouannet P

    更新日期:1997-06-01 00:00:00