Abstract：
OBJECTIVE:To determine whether the oncofetal protein IMP3 is detectable in endometriomas with or without histological atypia and whether IMP3 staining can be used as a triage tool to identify foci of atypical endometriosis in doubtful cases. DESIGN:Retrospective study. SETTING:Academic department and referral center for endometriosis. PATIENT(S):A consecutive series of 516 women who underwent excision of 874 endometriomas. INTERVENTION(S):Histological review by three expert pathologists and immunohistochemical staining for IMP3. MAIN OUTCOME MEASURE(S):Test performance of IMP3 immunohistochemistry versus first-round histology. RESULT(S):The prevalence of atypical endometriosis was 1.7% (95% confidence interval [CI], 0.9%-3.3%) based on the number of women and 1.0% (95% CI, 0.5%-1.9%) based on the number of cysts. Three cases of atypical endometriosis were identified at first-round histological examination. Immunohistochemistry detected seven of the eight cases diagnosed as preneoplastic atypia at second-round histology and one case diagnosed as reactive atypia at second-round histology. The sensitivity of first-round histology was 33.3%, compared with 88.9% of IMP3 immunohistochemistry. CONCLUSION(S):Immunohistochemical staining for IMP3 expression is a simple, inexpensive, and sensitive test that can be used in routine clinical practice as a triage tool to discriminate between cytological/structural atypia and confounding benign conditions.
journal_name
Fertil Steriljournal_title
Fertility and sterilityauthors
Vercellini P,Cribiù FM,Del Gobbo A,Carcangiu ML,Somigliana E,Bòsari Sdoi
10.1016/j.fertnstert.2013.02.002subject
Has Abstractpub_date
2013-06-01 00:00:00pages
1974-9issue
7eissn
0015-0282issn
1556-5653pii
S0015-0282(13)00255-0journal_volume
99pub_type
杂志文章abstract：OBJECTIVE:To measure the flow velocity of the uterine and ovarian arteries through the menstrual cycle to determine there are changes. DESIGN:Serial measurements throughout the menstrual cycle in women attending an infertility clinic, compared with volunteers coming for annual examinations. Transvaginal ultrasound-col...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)54657-3
更新日期：1991-11-01 00:00:00
abstract：OBJECTIVE:To investigate the effects of estrogen (E) alone or with cyclic, continuous, or interrupted P regimens on bone density in an aged rat model. DESIGN:Randomized controlled trial. ANIMALS:Twenty 12-month-old female Sprague-Dawley rats were sham operated (intact control) and 100 were ovariectomized (OVX). INTE...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：
更新日期：1995-03-01 00:00:00
abstract：OBJECTIVE:To consider the arguments for and against funding for in vitro fertilization (IVF) and to explore potential avenues for policy change. DESIGN:Narrative literature review, policy analysis. SETTING:University Department of Obstetrics and Gynecology. PATIENT(S):Sub-fertile women and men. INTERVENTION(S):Fert...
journal_title：Fertility and sterility
pub_type： 杂志文章,评审
doi：10.1016/s0015-0282(01)01928-8
更新日期：2001-09-01 00:00:00
abstract：OBJECTIVE:To introduce an innovation that combines single port laparoscopic and Wharton-Sheares-George cervicovaginal reconstruction using a small intestinal submucosa (SIS) graft in a patient with congenital cervical atresia, absence of vagina, and incomplete uterine septum (U2aC4V4). DESIGN:Video article introducing...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2019.11.011
更新日期：2020-03-01 00:00:00
abstract：:The administration of five subcutaneous 250-microgram doses of lutienizing hormone (LH)-releasing hormone (LHRH) at 4-hour intervals, the first injection being given at 8 A.M. on 1 or 2 consecutive days between days 1 and 9 following the LH surge in normal women, shortened the luteal phase from 1 to 4 days in 16 of 17...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)43755-6
更新日期：1979-01-01 00:00:00
abstract：OBJECTIVE:To review the literature concerning the regulation of follicle growth, to describe a model for unifollicular ovulation based upon the information gleaned, and to discuss some clinical implications in reproductive endocrinology underscored by this expanding knowledge. DESIGN:Studies relating to follicular gro...
journal_title：Fertility and sterility
pub_type： 杂志文章,评审
doi：10.1016/s0015-0282(16)58077-7
更新日期：1996-02-01 00:00:00
abstract：OBJECTIVE:To assess the effect of gonadotropin-releasing hormone agonist (GnRH-a) on pituitary suppression, subsequent ovarian response, and results of in vitro fertilization (IVF) treatments in polycystic ovarian syndrome (PCOS) patients. DESIGN:Randomized prospective study. SETTING:In vitro fertilization program an...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)54847-x
更新日期：1992-02-01 00:00:00
abstract：OBJECTIVE:To determine the degree of improvement in semen parameters after finasteride discontinuation. DESIGN:A prospective database of men presenting for a fertility evaluation was analyzed for semen and hormone parameters before and after discontinuation of finasteride. SETTING:A male infertility specialty clinic....
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2013.07.2000
更新日期：2013-12-01 00:00:00
abstract：:The high rates of unplanned pregnancy reflect an unmet need for effective contraceptive methods for women, especially for individuals with health risks such as obesity, diabetes, hypertension, and other conditions that may contraindicate use of an estrogen-containing product. Improvements in safety, user convenience, ...
journal_title：Fertility and sterility
pub_type： 杂志文章,评审
doi：10.1016/j.fertnstert.2016.07.1115
更新日期：2016-11-01 00:00:00
abstract：:Laparoscopic sterilization was performed on 50 racially distributed patients, aged 18-42 years, who were selected at random from the Outpatient Laparoscope Sterilization Clinic and offered sterilization under local anesthesia. The patients were injected with a systemic analgesic as well as a local anesthetic. One in...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)38530-2
更新日期：1971-10-01 00:00:00
abstract：:Salpingitis isthmica nodosa has been studied in relation to female infertility and tubal ectopic pregnancy. The incidence of this lesion in a control Caucasian population was 0.6%, as compared with incidences of 2.86% in an ectopic group and 50% in a small infertility group undergoing tuboplasty. It is suggested that ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：
更新日期：1978-02-01 00:00:00
abstract：:We found that there was no significant difference in endometrial responses to vaginal or IM P. But the response was suboptimal in cycles treated with dydrogesterone, suggesting that dydrogesterone treatment is not the preferred progestin for use in artificial cycles. ...
journal_title：Fertility and sterility
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0015-0282(16)56840-x
更新日期：1994-07-01 00:00:00
abstract：OBJECTIVE:To evaluate endometrial adhesion and invasion of peritoneal mesothelium. DESIGN:Descriptive study using confocal laser-scanning microscopy. SETTING:University-based laboratory. PATIENT(S):Women undergoing surgery for benign conditions. INTERVENTION(S):Fluorescence-labeled peritoneal mesothelial cells (PMC...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(02)04834-3
更新日期：2003-03-01 00:00:00
abstract：:In this prospective case-control study, we determined the role of surface-enhanced laser desorption and ionization time-of-flight mass spectrometry in the detection of histologically proven endometriosis. In the plasma of the group with endometriosis, there were 20 different protein peaks, and the classifier showed a ...
journal_title：Fertility and sterility
pub_type： 信件
doi：10.1016/j.fertnstert.2006.08.095
更新日期：2007-04-01 00:00:00
abstract：OBJECTIVE:To evaluate whether some ultrasound parameters of ovarian morphology can discriminate between control women and patients with polycystic ovary syndrome (PCOS). DESIGN:Retrospective data analysis. SETTING:Volunteers women in an academic research environment. PATIENT(S):Eighty amenorrheic or oligomenorrheic ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(01)01919-7
更新日期：2001-08-01 00:00:00
abstract：:Midluteal phase corpora lutea (CL) obtained from women induced with 50 mg (n = 5), 100 mg (n = 5), and 150 mg (n = 5) of clomiphene citrate (CC) were measured for luteinizing hormone/human chorionic gonadotropin (LH/hCG) concentrations and cytosol progesterone (P) and 17 alpha-hydroxyprogesterone (17-OHP) and compared...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：
更新日期：1990-10-01 00:00:00
abstract：:Sperm banking with the relatively simple and economical biologic freezer (Linde BF-5; Union Carbide Corporation, Linde Division, New York, N.Y.) was compared with controlled-rate freezer (Linde CRF-1; Union Carbide), using different freezing rates and cryoprotective media. The results were assessed by comparing prefre...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：
更新日期：1981-05-01 00:00:00
abstract：OBJECTIVE:To assess perinatal risk of major congenital anomalies in children born after embryo transfer with assisted hatching (AH). DESIGN:Retrospective cohort study. SETTING:Not applicable. PATIENT(S):Cycles registered from 2010 to 2012 and conceived via single-embryo transfer were included for the analysis. Live ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2015.03.029
更新日期：2015-07-01 00:00:00
abstract：OBJECTIVE:To describe different approaches for diagnosis and management of proximal ectopic pregnancies (PP) in general population. DESIGN:Observational population based-study. SETTING:Regional ectopic pregnancy registry. PATIENT(S):Eighty-six PP registered from 1992 to 2008. INTERVENTION(S):Surgical (radical or co...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2010.10.025
更新日期：2011-03-01 00:00:00
abstract：OBJECTIVE:To describe a 5-year experience of fluoroscopically guided hysteroscopic synechiolysis for Asherman's syndrome. DESIGN:Retrospective, uncontrolled cohort study. SETTING:Department of Endo-Gynaecology, University of New South Wales, Royal Hospital for Women, Randwick, Sydney, New South Wales, Australia. PAT...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2006.06.035
更新日期：2007-02-01 00:00:00
abstract：OBJECTIVE:To analyze relationship and parenthood in IVF twin couples, IVF singleton couples, and spontaneously pregnant primiparous couples. SETTING:Southeast region of Sweden. DESIGN:Prospective case-control study. PATIENT(S):In total, 24 women and men who became pregnant with twins, consecutively, and expected the...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2007.03.064
更新日期：2008-03-01 00:00:00
abstract：:The proportions of good, fair, and poor embryos in 13 women with bilateral endometriomas were compared with those of 39 women without endometriomas and were found to be similar (47.2% vs. 41.1%, 28.3% vs. 32.8%, and 24.3% vs. 26.0%, respectively). Therefore, it appears that the presence of bilateral endometriomas duri...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2011.03.002
更新日期：2011-06-30 00:00:00
abstract：OBJECTIVE:To examine the factors influencing the development of adhesions after laparoscopic myomectomy (LM) and the efficacy of adhesion-preventing agents. DESIGN:Prospective nonrandomized study. SETTING:University-affiliated hospital. PATIENT(S):Three hundred seventy-two patients who underwent LM alone by the same...
journal_title：Fertility and sterility
pub_type： 临床试验,杂志文章
doi：10.1016/j.fertnstert.2007.05.021
更新日期：2008-05-01 00:00:00
abstract：OBJECTIVE:To report the birth of a healthy female infant from a father with nonmosaic Klinefelter syndrome (KS) and document the experience of men with KS undergoing assisted conception. DESIGN:Retrospective. SETTING:Private IVF center. PATIENT(S):Twelve couples with male factor infertility due to Klinefelter syndro...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(03)01157-9
更新日期：2003-10-01 00:00:00
abstract：OBJECTIVE:To determine the expression of nitric oxide synthases (NOSs) and their modulation by hypoxia in human peritoneal (NF) and adhesion fibroblasts (ADF). DESIGN:Prospective experimental study. SETTING:University medical center. PATIENT(S):Fibroblasts from peritoneum and adhesion tissues. INTERVENTION(S):Hypox...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2007.07.1313
更新日期：2008-09-01 00:00:00
abstract：:Patients undergoing controlled ovarian hyperstimulation and pituitary suppression with a GnRH antagonist who experienced a transient premature rise in LH were compared with those who did not have an early surge. Those experiencing a premature LH surge had equivalent clinical and ongoing pregnancy rates per ET. ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2010.12.046
更新日期：2011-06-30 00:00:00
abstract：OBJECTIVE:To review current knowledge regarding recombinant DNA technology and its safety and efficacy in relation to recombinant gonadotropin production. DATA IDENTIFICATION AND SELECTION:Studies that relate specifically to recombinant DNA technology, method of laboratory production, and the clinical aspects of using...
journal_title：Fertility and sterility
pub_type： 杂志文章,评审
doi：10.1016/s0015-0282(16)58437-4
更新日期：1996-08-01 00:00:00
abstract：:Plasma preptin levels were higher in women with PCOS compared with the control group (mean±SD, 823.2±140.7 vs. 324.9±147.3 pg/mL). This article suggests a potential role of preptin in the pathogenesis of PCOS. ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2010.08.058
更新日期：2011-01-01 00:00:00
abstract：:Hysteroscopic examination of the uterine cavity revealed that patients previously treated for intramural myoma(s) by uterine artery embolization had a significantly higher incidence of abnormal findings compared with patients treated by laparoscopic occlusion of uterine arteries (59.5% vs. 2.7%). In particular, there ...
journal_title：Fertility and sterility
pub_type： 临床试验,杂志文章
doi：10.1016/j.fertnstert.2010.12.014
更新日期：2011-05-01 00:00:00
abstract：OBJECTIVE:To evaluate the efficacy of transvaginal intratubal methotrexate (MTX) treatment of tubal ectopic pregnancy (EP). SETTING:Outpatient setting in University Hospital. PATIENTS:Forty women with early EP and rising serum beta-human chorionic gonadotropin (beta-hCG) levels. INTERVENTION:Transvaginal intratubal ...
journal_title：Fertility and sterility
pub_type： 临床试验,杂志文章
doi：10.1016/s0015-0282(16)55143-7
更新日期：1992-07-01 00:00:00
