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Cytokine gene polymorphisms in northern Indian women with recurrent miscarriages.

Abstract：

OBJECTIVE:To determine association of cytokine gene polymorphism with risk for recurrent miscarriages (RM). DESIGN:Retrospective case-control study on northern Indian RM cases versus control subjects. SETTING:Medical facility. PATIENT(S):A total of 200 women with at least three unexplained spontaneous abortions before 20 weeks of gestation. INTERVENTION(S):Subjects were genotyped by polymerase chain reaction amplification followed by restriction digestion and allele-specific oligonucleotides. MAIN OUTCOME MEASURE(S):Detection of pro- and antiinflammatory gene polymorphism genotypes and allele frequencies. RESULT(S):We applied dominant and recessive models of inheritance, showing no association among T(H)2 [interleukin (IL) 10 (592 C/A) and transforming growth factor β] gene polymorphisms, while significant association was observed between T(H)2 [IL-4 (C590T), IL-6 (G174C), IL-10 (1082A/G and 819C/T)], and T(H)1 [interferon-γ (+874A/T)] with RM compared with control subjects. However, when classification and regression tree analysis was applied, this effect disappeared and demonstrated that IL-10 plays an important role in maintenance of pregnancy. CONCLUSION(S):Interleukin-10 acts as an immunosuppressive by keeping a balance of pro- and antiinflammatory signals that coordinate the satisfactory development of pregnancy, placental growth, and remodeling for favorable pregnancy outcome.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Parveen F,Shukla A,Agarwal S

doi

10.1016/j.fertnstert.2012.09.025

subject

Has Abstract

pub_date

2013-02-01 00:00:00

pages

433-40

issue

2

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(12)02244-3

journal_volume

99

pub_type

杂志文章

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