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Subfertility and the risk of low birth weight.

Abstract：

OBJECTIVE:We evaluated the association between subfertility and low birth weight infants. DESIGN:Women in this analysis participated in a cross-sectional investigation of maternal risk factors for adverse pregnancy outcomes. SETTING:Medical and obstetric history and life style information were obtained from women who delivered at the Boston Hospital for Women, 1977 to 1980. PATIENTS, PARTICIPANTS:Our analysis was restricted to nondiabetic married women who planned their pregnancies and subsequently delivered viable singletons (3,622). The 644 "subfertile" women (no conception during a year of unprotected intercourse) were compared with 2,978 "fertile" women (conception within 1 year). MAIN OUTCOME MEASURE(S):The relative risk of low birth weight was estimated using the cumulative incidence risk ratio. RESULTS:After adjusting for confounding, the relative risk of delivering a low birth weight infant (less than 2,500 g) for subfertile women versus fertile women was 1.9 (95% confidence interval [CI], 1.3 to 2.8). The adjusted relative risk of delivering a term low birth weight (intrauterine growth retarded) infant was 2.3 (95% CI, 1.2 to 4.4). CONCLUSIONS:In these data, subfertility is a predictor for low birth weight. The association may result from endocrinological, immunological, cervical, or other factors that interfere with optimal fetal growth.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Williams MA,Goldman MB,Mittendorf R,Monson RR

doi

10.1016/s0015-0282(16)54597-x

subject

Has Abstract

pub_date

1991-10-01 00:00:00

pages

668-71

issue

4

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(16)54597-X

journal_volume

56

pub_type

杂志文章

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