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Immunological aspects of surgically induced experimental endometriosis: variation in response to therapy.

Abstract：

:Elevated endometrial antibody titers were detected in serum and peritoneal fluid of rabbits with experimentally induced endometriosis. Surgical extirpation of implants or suppression with gonadotropin-releasing hormone agonist resulted in decreased endometrial antibody titers, whereas the antibody titers in untreated rabbits with endometriosis increased significantly. Endometrial implants and normal endometrial tissue had similar proteins by polyacrylamide gel electrophoresis. However, the serum and peritoneal fluid from rabbits with experimentally induced endometriosis had gamma G immunoglobulin antibodies to an endometrial protein with molecular weight of approximately 40 kD. These antibodies were absent in rabbits without endometriosis. Isolation of endometrial antigens eliciting the humoral immune response in endometriosis may aid in the development of a specific antibody marker for endometriosis.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Homm RJ,Garza DE,Mathur S,Austin M,Baggett B,Williamson HO

doi

10.1016/s0015-0282(16)60802-6

subject

Has Abstract

pub_date

1989-07-01 00:00:00

pages

132-9

issue

1

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(16)60802-6

journal_volume

52

pub_type

杂志文章

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