First trimester screening for Down's syndrome after assisted reproductive technology: non-male factor infertility is associated with elevated free beta-human chorionic gonadotropin levels at 10-14 weeks of gestation.

Abstract:

:We retrospectively compared the first trimester Down's syndrome serum screening markers free beta-hCG (fbetahCG) and pregnancy-associated plasma protein-A (PAPP-A) at 11-14 weeks of gestation in 4,088 women with naturally conceived pregnancies and in women pregnant after ICSI (n = 163), IVF (n = 59) and frozen-thawed embryo transfer (n = 31), and we searched for a potential relationship between infertility cause and marker levels. We found lower serum PAPP-A levels in pregnancies after IVF and ICSI compared with spontaneously conceived pregnancies and non-male factor infertility was associated with elevated serum fbetahCG levels at 11-14 weeks of gestation.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Anckaert E,Schiettecatte J,Sleurs E,Devroey P,Smitz J

doi

10.1016/j.fertnstert.2007.08.050

subject

Has Abstract

pub_date

2008-10-01 00:00:00

pages

1206-10

issue

4

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(07)03393-6

journal_volume

90

pub_type

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