BRCA mutation carriers show normal ovarian response in in vitro fertilization cycles.

Abstract:

OBJECTIVE:To evaluate the association between carriage of BRCA1/2 mutations and ovarian performance, as demonstrated by in vitro fertilization (IVF) outcomes. DESIGN:Retrospective cohort study. SETTING:Two tertiary IVF centers. PATIENT(S):BRCA mutation carriers undergoing IVF for preimplantation genetic diagnosis (PGD) or fertility preservation were compared with non-BRCA PGD or fertility preservation patients, matched by age, IVF protocol, IVF center, and cancer disease status. INTERVENTION(S):In vitro fertilization cycles for PGD and fertility preservation. MAIN OUTCOME MEASURE(S):Outcome of IVF: oocyte yield, poor response rate, number of zygotes, pregnancy rates. RESULT(S):A total of 62 BRCA mutation carriers and 62 matched noncarriers were included; 42 were fertility preservation breast cancer patients, and 82 were PGD non-cancer patients. Mean (± SD) age of patients was 32 ± 3.58 years. Number of stimulation days and total stimulation dose were comparable between carriers and noncarriers. Their cycles resulted in comparable oocyte yield (13.75 vs. 14.75) and low response rates (8.06% vs. 6.45%). Number of zygotes, fertilization rates, and conception rates were also comparable. CONCLUSION(S):Both healthy and cancer-affected BRCA mutation carriers demonstrated normal ovarian response in IVF cycles.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Shapira M,Raanani H,Feldman B,Srebnik N,Dereck-Haim S,Manela D,Brenghausen M,Geva-Lerner L,Friedman E,Levi-Lahad E,Goldberg D,Perri T,Eldar-Geva T,Meirow D

doi

10.1016/j.fertnstert.2015.07.1162

subject

Has Abstract

pub_date

2015-11-01 00:00:00

pages

1162-7

issue

5

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(15)01674-X

journal_volume

104

pub_type

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