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Endometrial infusion of human chorionic gonadotropin at the time of blastocyst embryo transfer does not impact clinical outcomes: a randomized, double-blind, placebo-controlled trial.

Abstract：

OBJECTIVE:To determine whether endometrial hCG infusion at the time of human blastocyst transfer impacts implantation rates. DESIGN:Randomized double-blinded placebo-controlled trial. SETTING:Academic. PATIENT(S):Infertile couples with the female partner less than 43 years old (n = 300) undergoing fresh or frozen ET of one or two blastocysts. INTERVENTION(S):Patients undergoing ET were randomized into either a treatment or a control group. The treatment group received an infusion of 500 IU of hCG diluted in ET media. The control group received a sham infusion of ET media. Infusions were done using a separate catheter less than 3 minutes before actual ET. MAIN OUTCOME MEASURE(S):Sustained implantation rate: ongoing viable gestation (primary outcome) and ongoing pregnancy rate (secondary outcome). RESULT(S):A total of 473 blastocysts were transferred into 300 patients. There were no differences between the two groups in sustained implantation rate (48.1% in the hCG group, 44.2% in the control group) or ongoing pregnancy rate (58.8% in the hCG group, 52.0% in the control group). CONCLUSION(S):Endometrial infusion of hCG at the time of blastocyst ET does not improve sustained implantation rates. CLINICAL TRIAL REGISTRATION NUMBER:NCT01643993.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Hong KH,Forman EJ,Werner MD,Upham KM,Gumeny CL,Winslow AD,Kim TJ,Scott RT Jr

doi

10.1016/j.fertnstert.2014.08.006

subject

Has Abstract

pub_date

2014-12-01 00:00:00

pages

1591-5.e2

issue

6

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(14)02065-2

journal_volume

102

pub_type

杂志文章,随机对照试验

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