当前位置： SCI文献检索 > FERTILITY AND STERILITY期刊下所有文献 > Efficacy of tibolone as "add-back therapy" in conjunction with a gonadotropin-releasing hormone analogue in the treatment of uterine fibroids.

Efficacy of tibolone as "add-back therapy" in conjunction with a gonadotropin-releasing hormone analogue in the treatment of uterine fibroids.

Abstract：

OBJECTIVE:To assess the efficacy of tibolone add-back therapy with Goserelin treatment of uterine fibroids. DESIGN:Randomized placebo-controlled study. SETTING:Gynecology department of an inner-city teaching hospital. PATIENT(S):Seventy-five women of reproductive age with uterine fibroids. INTERVENTION(S):All women were given monthly SC implants of 3.6 mg goserelin and were randomized to take 3 months of placebo followed by 3 months of tibolone 2.5 mg daily (delayed administration), tibolone 2.5 mg daily for 6 months, or placebo for 6 months. MAIN OUTCOME MEASURE(S):Changes in bone mineral density (BMD) at the hip and spine, fibroid and uterine size, and patient symptomatology. RESULT(S):In the tibolone group, 2% loss of BMD at the spine was observed compared with 5.5% loss in the placebo group. For total hip, tibolone led to a 0.7% gain in BMD compared with a loss of 1.7% in the placebo group. Tibolone did not affect GnRH analogue-induced fibroid shrinkage. Vasomotor symptom scores in women taking tibolone were 2.2 and were significantly lower than those taking placebo or in the delayed administration groups (mean scores 2.9 and 2.7, respectively). CONCLUSION(S):Tibolone appears to be a safe and effective add-back therapy which can be given from the commencement of GnRH analogue treatment for fibroids.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Morris EP,Rymer J,Robinson J,Fogelman I

doi

10.1016/j.fertnstert.2007.02.064

subject

Has Abstract

pub_date

2008-02-01 00:00:00

pages

421-8

issue

2

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(07)00539-0

journal_volume

89

pub_type

杂志文章,随机对照试验

相关文献

FERTILITY AND STERILITY文献大全
  • Changing parameters of donor semen.

    abstract：:Effective contraception and easily available abortion have contributed to the decline of adoptable children. This decline has resulted in a marked increase in the demand for AID. The provider of donor semen must establish minimal semen criteria to meet this demand effectively. During the past 8 years the authors have ...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(16)45923-6

    authors： Leto S,Frensilli FJ

    更新日期：1981-12-01 00:00:00

  • Postmolar gestational trophoblastic neoplasia: beyond the traditional risk factors.

    abstract：OBJECTIVE:To investigate the slope of linear regression of postevacuation serum hCG as an independent risk factor for postmolar gestational trophoblastic neoplasia (GTN). DESIGN:Multicenter retrospective cohort study. SETTING:Academic referral health care centers. PATIENT(S):All subjects with confirmed hydatidiform ...

    journal_title：Fertility and sterility

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.fertnstert.2015.06.001

    authors： Bakhtiyari M,Mirzamoradi M,Kimyaiee P,Aghaie A,Mansournia MA,Ashrafi-Vand S,Sarfjoo FS

    更新日期：2015-09-01 00:00:00

  • Plasma lipids and desogestrel and ethinyl estradiol: a meta-analysis.

    abstract：OBJECTIVE:To review the literature to determine the magnitude of the effect of 150 micrograms desogestrel-30 micrograms ethinyl E2, an oral contraceptive (OC) formulation, on plasma lipid concentrations in healthy women using meta-analysis techniques. DATA SOURCES:All English-language published reports (1981 to 1991) ...

    journal_title：Fertility and sterility

    pub_type： 杂志文章,meta分析

    doi：

    authors： Lobo RA,Skinner JB,Lippman JS,Cirillo SJ

    更新日期：1996-06-01 00:00:00

  • Novel fumarate hydratase mutation in a family with atypical uterine leiomyomas and hereditary leiomyomatosis and renal cell cancer.

    abstract：OBJECTIVE:To describe a novel mutation in the fumarate hydratase (FH) gene in a family with atypical uterine leiomyomas. DESIGN:Case report and review of the literature. SETTING:Academic community hospital. PATIENT(S):Three sisters who presented as nulligravidas aged 27-30 years with large atypical uterine leiomyoma...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2015.09.034

    authors： Wheeler KC,Warr DJ,Warsetsky SI,Barmat LI

    更新日期：2016-01-01 00:00:00

  • Serum antisperm antibodies in men with vas deferens obstruction caused by childhood inguinal herniorrhaphy.

    abstract：OBJECTIVE:To study the incidence of serum antisperm antibodies in patients with vas deferens obstruction caused by childhood inguinal herniorrhaphy. DESIGN:Retrospective. SETTING:Kansai Medical University and Kyoto University Hospital. PATIENTS:Thirteen patients with vas deferens obstruction caused by childhood ingu...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(16)55934-2

    authors： Matsuda T,Muguruma K,Horii Y,Ogura K,Yoshida O

    更新日期：1993-05-01 00:00:00

  • Effect of antifreeze protein supplementation in vitrification medium on mouse oocyte developmental competence.

    abstract：OBJECTIVE:To investigate the effect of antifreeze protein (AFP) supplementation during mouse oocyte vitrification on the survival, fertilization and embryonic development. DESIGN:Animal study. SETTING:University laboratory. ANIMAL(S):BDF-1 mice. INTERVENTION(S):In vivo-matured metaphase II oocytes were vitrified wi...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2011.08.023

    authors： Jo JW,Jee BC,Lee JR,Suh CS

    更新日期：2011-11-01 00:00:00

  • Effects of pentoxifylline on human sperm motility in normospermic individuals using computer-assisted analysis.

    abstract：OBJECTIVE:To determine if pentoxifylline has an in vitro effect on human sperm motility in subjects with normal semen analysis. DESIGN:Prospective, longitudinal study of the effect of pentoxifylline on normospermic semen samples using computerized analysis. SETTING:The Assisted Conception Unit, Royal Maternity Hospit...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(16)55708-2

    authors： Lewis SE,Moohan JM,Thompson W

    更新日期：1993-02-01 00:00:00

  • Intronic variation of the SOHLH2 gene confers risk to male reproductive impairment.

    abstract：OBJECTIVE:To evaluate whether SOHLH2 intronic variation contributes to the genetic predisposition to male infertility traits, including severe oligospermia (SO) and different nonobstructive azoospermia (NOA) clinical phenotypes. DESIGN:Genetic association study. SETTING:Not applicable. PATIENT(S):Five hundred five c...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2020.02.115

    authors： Cerván-Martín M,Suazo-Sánchez MI,Rivera-Egea R,Garrido N,Luján S,Romeu G,Santos-Ribeiro S,Castilla JA,Gonzalvo MC,Clavero A,Vicente FJ,Maldonado V,Burgos M,Barrionuevo FJ,Jiménez R,Sánchez-Curbelo J,López-Rodrigo O,Pera

    更新日期：2020-08-01 00:00:00

  • Trophectoderm biopsy reduces the level of serum β-human chorionic gonadotropin in early pregnancy.

    abstract：OBJECTIVE:To assess whether trophectoderm biopsy has any impact on the level of serum β-human chorionic gonadotropin (β-hCG) in early pregnancies. DESIGN:Retrospective cohort study. SETTING:University-affiliated reproductive medical center. PATIENT(S):Three hundred and eighty-three women undergoing 396 frozen embryo...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2020.05.015

    authors： Lu MM,Wen YX,Liu YL,Ding CH,Zhou CQ,Xu YW

    更新日期：2020-10-01 00:00:00

  • Serum levels of soluble vascular cell adhesion molecule-1, tumor necrosis factor-alpha, and interleukin-6 in in vitro fertilization cycles.

    abstract：OBJECTIVE:To assess whether gonadotropin-induced changes in E(2) alter serum levels of soluble vascular cell adhesion molecule-1 (sVCAM-1) and proinflammatory cytokines. DESIGN:Prospective collection of serum in patients undergoing IVF. SETTING:University hospital. PATIENT(S):Twenty-four infertile women. INTERVENTI...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2008.04.039

    authors： Souter I,Huang A,Martinez-Maza O,Breen EC,Decherney AH,Chaudhuri G,Nathan L

    更新日期：2009-05-01 00:00:00

  • Mutation profiles and clinical characteristics of Chinese males with isolated hypogonadotropic hypogonadism.

    abstract：OBJECTIVE:To investigate the mutation profiles and clinical characteristics of Chinese males with isolated hypogonadotropic hypogonadism (IHH) and discover new pathogenic genes that cause IHH. DESIGN:A gene panel, including 31 known IHH genes and 52 candidate genes, was used to perform semiconductor next-generation se...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2018.04.010

    authors： Zhou C,Niu Y,Xu H,Li Z,Wang T,Yang W,Wang S,Wang DW,Liu J

    更新日期：2018-08-01 00:00:00

  • Laparoscopic metroplasty: reconstructive surgery for unicornuate uterus with noncommunicating, functional uterine horn.

    abstract：OBJECTIVE:To demonstrate laparoscopic surgery for a patient with unicornuate uterus and a large hematometra in the noncommunicating uterine horn. DESIGN:Narrated video featuring the diagnostic tests and surgical management. SETTING:Academic tertiary hospital. PATIENT(S):A 13-year-old woman, gravida 0 with menarche a...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2020.05.042

    authors： Yen CF,Hsin-Yu Pai A,Lo A,Chueh HY,Huang HY,Lin SL

    更新日期：2020-11-01 00:00:00

  • Randomized, double-blind, placebo-controlled study of the effects of raloxifene and conjugated equine estrogen on plasma homocysteine levels in healthy postmenopausal women.

    abstract：OBJECTIVE:To investigate the long-term effects of raloxifene on fasting plasma homocysteine levels in postmenopausal women compared with conjugated equine estrogen (CEE). DESIGN:Randomized, double-blind, placebo-controlled study. SETTING:Outpatient department of a university hospital. PATIENT(S):Fifty-two hysterecto...

    journal_title：Fertility and sterility

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0015-0282(98)00381-1

    authors： Mijatovic V,Netelenbos C,van der Mooren MJ,de Valk-de Roo GW,Jakobs C,Kenemans P

    更新日期：1998-12-01 00:00:00

  • Strategies to minimize discomfort during diagnostic hysterosalpingography with disposable balloon catheters: a randomized placebo-controlled study with oral nonsteroidal premedication.

    abstract：OBJECTIVE:To assess whether oral administration of 100 mg of nimesulide reduces pain during or after a hysterosalpingography (HSG) performed with disposable balloon catheters. DESIGN:Prospective, randomized, placebo-controlled study. SETTING:Reproductive Centre, Department of Obstetrics and Gynaecology, University of...

    journal_title：Fertility and sterility

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.fertnstert.2007.07.1302

    authors： Anserini P,Delfino F,Ferraiolo A,Remorgida V,Menoni S,De Caro G

    更新日期：2008-09-01 00:00:00

  • Measurement of serosal temperatures and depth of thermal injury generated by thermal balloon endometrial ablation in ex vivo and in vivo models.

    abstract：OBJECTIVE:To evaluate the safety profile of endometrial ablation performed with a thermal balloon as defined by serosal temperature elevation and depth of injury. DESIGN:Observational study with histopathologic correlation conducted in ex vivo and in vivo phases. SETTING:Academic medical center. PATIENT(S):Twenty pa...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(98)00245-3

    authors： Shah AA,Stabinsky SA,Klusak T,Bradley KR,Steege JF,Grainger DA

    更新日期：1998-10-01 00:00:00

  • Comparisons of inhibin B versus antimüllerian hormone in poor ovarian responders undergoing in vitro fertilization.

    abstract：OBJECTIVE:To evaluate serum inhibin B as a predictor of poor ovarian response in patients undergoing in vitro fertilization/intracytoplasmic sperm injection (IVF-ICSI) and to compare it with the performance of antimüllerian hormone (AMH). DESIGN:Meta-analysis. SETTING:University hospital. PATIENT(S):Patients undergo...

    journal_title：Fertility and sterility

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.fertnstert.2011.07.1102

    authors： Tan R,Pu D,Liu L,Liu J,Wu J

    更新日期：2011-10-01 00:00:00

  • Congenital obstructive azoospermia in a man with Marfan syndrome.

    abstract：OBJECTIVE:To present a case of Marfan syndrome and concurrent congenital obstructive azoospermia. DESIGN:Case report. SETTING:Tertiary-care academic hospital. PATIENT(S):A man with Marfan syndrome and obstructive azoospermia. INTERVENTION(S):The patient was evaluated for azoospermia that was proved to be due to con...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(01)02868-0

    authors： Kukuvitis A,Georgiou I,Ioannidis S,Tarlatzis B,Bontis J,Papadimas J

    更新日期：2001-12-01 00:00:00

  • Molecular analysis of the neuropeptide Y1 receptor gene in human idiopathic gonadotropin-dependent precocious puberty and isolated hypogonadotropic hypogonadism.

    abstract：OBJECTIVE:To investigate the role of mutations or polymorphisms in the NPY-Y1R gene in human idiopathic central pubertal disorders. DESIGN:Molecular studies. SETTING:University hospital. PATIENT(S):Thirty-three patients with gonadotropin-dependent precocious puberty, 22 with hypogonadotropic hypogonadism, and 50 con...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2006.07.1519

    authors： Freitas KC,Ryan G,Brito VN,Tao YX,Costa EM,Mendonca BB,Segaloff D,Latronico AC

    更新日期：2007-03-01 00:00:00

  • Effect of halving the daily dose of triptorelin at the start of ovarian stimulation on hormone serum levels and the outcome of in vitro fertilization.

    abstract：:Halving the standard daily dose of triptorelin at the start of ovarian stimulation in down-regulated women stimulated with recombinant FSH is enough for pituitary suppression and was associated with higher LH serum concentrations in the follicular phase. However, this did not translate into higher serum concentrations...

    journal_title：Fertility and sterility

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.fertnstert.2004.10.032

    authors： Fábregues F,Peñarrubia J,Creus M,Casamitjana R,Vanrell JA,Balasch J

    更新日期：2005-03-01 00:00:00

  • Public perspectives on placing age limits on men and women seeking fertility treatment.

    abstract：OBJECTIVE:To assess public attitudes toward placing age limits on men and women seeking fertility treatment. DESIGN:Cross-sectional web-based survey. SETTING:Not applicable. PATIENT(S):A nationally representative sample of 1,427 adults in the United States. INTERVENTION(S):Not applicable. MAIN OUTCOME MEASURE(S):S...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2018.11.019

    authors： Lee MS,Farland LV,Thomas AM,Ginsburg ES

    更新日期：2019-03-01 00:00:00

  • Accuracy of hysterosalpingography and laparoscopic hydrotubation in diagnosis of tubal patency.

    abstract：OBJECTIVE:To compare the diagnostic accuracy of two methods of assessment of tubal patency, viz, hysterosalpingography (HSG) and laparoscopic hydrotubation. DESIGN:One hundred four infertile women who were investigated with both HSG and laparoscopy in King Khalid University Hospital were selected for the study. Comple...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(16)57540-2

    authors： Adelusi B,al-Nuaim L,Makanjuola D,Khashoggi T,Chowdhury N,Kangave D

    更新日期：1995-05-01 00:00:00

  • Women with reduced ovarian reserve or advanced maternal age have an altered follicular environment.

    abstract：OBJECTIVE:To determine whether altered follicular environment is associated with ovarian reserve or maternal age. DESIGN:Prospective study examining follicular fluid (FF) composition and follicular cell metabolism. SETTING:University research department and private IVF clinic. PATIENT(S):Women (n = 54) undergoing ro...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2012.06.025

    authors： Pacella L,Zander-Fox DL,Armstrong DT,Lane M

    更新日期：2012-10-01 00:00:00

  • Inflammatory bowel disease and male infertility: effects of sulfasalazine and 5-aminosalicylic acid on sperm-fertilizing capacity and reactive oxygen species generation.

    abstract：:To investigate the mechanism of the antifertility action of sulfasalazine, we prospectively measured sperm density, motility, hamster oocyte penetration capacity, and reactive oxygen species production in six men with inflammatory bowel disease being treated with sulfasalazine and 8 and 16 weeks after changing to 5-am...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(16)53050-7

    authors： Wu FC,Aitken RJ,Ferguson A

    更新日期：1989-11-01 00:00:00

  • Assessment of testicular cytology by fine needle aspiration as a diagnostic parameter in the evaluation of the azoospermic subject.

    abstract：OBJECTIVE:To investigate whether testicular cytology by fine needle aspiration (FNA) may be considered a diagnostic parameter in the evaluation of the azoospermic subject. DESIGN:Cytologic smears were obtained using a 23-G needle, stained with May-Grünwald-Giemsa stain and examined under a light Orthoplan microscope (...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(16)54971-1

    authors： Foresta C,Varotto A,Scandellari C

    更新日期：1992-04-01 00:00:00

  • Factors of importance for the establishment of a successful program of intracytoplasmic sperm injection treatment for male infertility.

    abstract：OBJECTIVE:To establish an intracytoplasmic sperm injection treatment program for couples with male infertility and to determine those factors important for success. DESIGN:A retrospective analysis of 171 consecutive cycles of intracytoplasmic sperm injection concerning 145 infertile couples. SETTING:Infertility clini...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(16)57489-5

    authors： Svalander P,Forsberg AS,Jakobsson AH,Wikland M

    更新日期：1995-04-01 00:00:00

  • Study of nucleation status in the second cell cycle of human embryo and its impact on implantation rate.

    abstract：OBJECTIVE:To study nucleation status in two- and four-cell embryos and its effect on reproductive outcomes. DESIGN:Retrospective cohort study. SETTING:University-affiliated private center. PATIENT(S):A total of 1,679 embryos from 940 oocyte donation cycles from May 2012 to May 2014. INTERVENTION(S):None. MAIN OUTC...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2016.03.036

    authors： Aguilar J,Rubio I,Muñoz E,Pellicer A,Meseguer M

    更新日期：2016-08-01 00:00:00

  • Effect of sperm treatment with exogenous platelet-activating factor on the outcome of intrauterine insemination.

    abstract：OBJECTIVE:To evaluate the effect of sperm treatment with exogenous platelet-activating factor (PAF) on IUI clinical pregnancy rate. DESIGN:Prospective randomized study. SETTING:Assisted Reproduction Unit, 2nd Department of Obstetrics and Gynecology, University of Athens, Aretaieion Hospital, Athens, Greece. SUBJECT(...

    journal_title：Fertility and sterility

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/j.fertnstert.2004.07.980

    authors： Grigoriou O,Makrakis E,Konidaris S,Hassiakos D,Papadias K,Baka S,Creatsas G

    更新日期：2005-03-01 00:00:00

  • Dichorionic quadramniotic quadruple gestation with monochorionic triamniotic triplets after two embryos transfer and selective reduction to twin pregnancy: case report.

    abstract：OBJECTIVE:To report a dichorionic quadramniotic quadruple gestation with monochorionic triamniotic triplets after intracytoplasmic sperm injection (ICSI) treatment and transfer of two embryos. DESIGN:Case report. SETTING:Academic reproductive medicine center. PATIENT(S):A 28-year-old nulligravida who underwent first...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2009.08.022

    authors： Li Y,Yang D,Zhang Q

    更新日期：2009-12-01 00:00:00

  • Histologic analysis of endometriomas: what the surgeon needs to know.

    abstract：OBJECTIVE:To evaluate by thorough pathologic analysis the histologic features of the endometrioma wall excised at laparoscopy. DESIGN:Prospective series of consecutive patients. SETTING:Tertiary care, university hospital. PATIENT(S):Fifty-nine patients with ovarian endometriomas. A total of 70 cysts were examined. ...

    journal_title：Fertility and sterility

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.fertnstert.2006.06.055

    authors： Muzii L,Bianchi A,Bellati F,Cristi E,Pernice M,Zullo MA,Angioli R,Panici PB

    更新日期：2007-02-01 00:00:00

  • Fertility, pregnancy, and medical management of Turner syndrome in the reproductive years.

    abstract：:Turner syndrome results in infertility in most cases. Fertility preservation through the cryopreservation of oocytes or ovarian tissue may be an option for some girls with Turner syndrome. Oocyte donation results in high pregnancy rates (PR). Those women who plan to pursue pregnancy need comprehensive screening and co...

    journal_title：Fertility and sterility

    pub_type： 杂志文章,评审

    doi：10.1016/j.fertnstert.2012.08.022

    authors： Karnis MF

    更新日期：2012-10-01 00:00:00