当前位置： SCI文献检索 > FERTILITY AND STERILITY期刊下所有文献 > Randomized, double-blind, placebo-controlled study of the effects of raloxifene and conjugated equine estrogen on plasma homocysteine levels in healthy postmenopausal women.

Randomized, double-blind, placebo-controlled study of the effects of raloxifene and conjugated equine estrogen on plasma homocysteine levels in healthy postmenopausal women.

Abstract：

OBJECTIVE:To investigate the long-term effects of raloxifene on fasting plasma homocysteine levels in postmenopausal women compared with conjugated equine estrogen (CEE). DESIGN:Randomized, double-blind, placebo-controlled study. SETTING:Outpatient department of a university hospital. PATIENT(S):Fifty-two hysterectomized, healthy postmenopausal women. INTERVENTION(S):Oral raloxifene in two dosages (60 mg/d [n=13] and 150 mg/d [n=13]), oral CEE (0.625 mg/d [n=13], and placebo (n=13) were given for 24 months. MAIN OUTCOME MEASURE(S):Fasting plasma homocysteine concentrations. RESULT(S):Plasma homocysteine levels were not altered in the placebo group. After 12 months, a significant reduction versus baseline in the mean plasma homocysteine level (-16%) was found only in the raloxifene 150-mg group. The mean change in plasma homocysteine levels within this group also was significantly different from the changes versus baseline found in the placebo group (+2%) and the raloxifene 60-mg group (-2%), but not different from those found in the CEE group (-8%). After 24 months, plasma homocysteine levels were decreased significantly in the raloxifene 150-mg and CEE groups compared with both baseline (-13% and -10%, respectively) and placebo values (-15% and -11%, respectively). No significant change in plasma homocysteine levels was observed in the raloxifene 60-mg group. CONCLUSION(S):Raloxifene has a favorable, dose-related effect on plasma homocysteine levels in postmenopausal women.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Mijatovic V,Netelenbos C,van der Mooren MJ,de Valk-de Roo GW,Jakobs C,Kenemans P

doi

10.1016/s0015-0282(98)00381-1

subject

Has Abstract

pub_date

1998-12-01 00:00:00

pages

1085-9

issue

6

eissn

0015-0282

issn

1556-5653

pii

S0015028298003811

journal_volume

70

pub_type

临床试验,杂志文章,随机对照试验

相关文献

FERTILITY AND STERILITY文献大全
  • Pharmacodynamics of the antiprogesterone RU486 in women after oral administration.

    abstract：:The pharmacokinetic characteristics of RU486 and its acute effects on anterior pituitary hormone secretion after oral administration were examined in six normal women. Serum RU486 concentrations were determined by a radioimmunoassay. The absorption of RU486 was rapid with peak serum levels reached approximately 90 min...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(16)60067-5

    authors： Liu JH,Garzo VG,Yen SS

    更新日期：1988-08-01 00:00:00

  • Relook hysteroscopy after antitubercular therapy.

    abstract：:Hysteroscopic visualization of the endometrium after 6 months of antitubercular therapy showed an improvement in the mucosal morphology. A closer visualization at increased magnification was helpful in demonstrating the remnants of a healing tubercular pathology after antitubercular therapy. ...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2007.07.1346

    authors： Kumar A,Kumar A

    更新日期：2008-03-01 00:00:00

  • Successful microsurgical removal of a pronucleus from tripronuclear human zygotes.

    abstract：:We have microsurgically extracted a pronucleus from 11 tripronuclear human zygotes under two different experimental conditions. One group of six zygotes was incubated in cytochalasin D for 30 minutes before manipulation. The remaining five zygotes were manipulated without preincubation in cytoskeletal relaxing agents....

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(16)60901-9

    authors： Gordon JW,Grunfeld L,Garrisi GJ,Navot D,Laufer N

    更新日期：1989-09-01 00:00:00

  • Comparison of Cryotip vs. Cryotop for mouse and human blastomere vitrification.

    abstract：OBJECTIVE:Compare the efficiency of two vitrification methods for single-blastomere cryopreservation with mouse or human embryos. DESIGN:Experimental prospective controlled study. SETTING:Research center. PATIENT(S):Human Blastomeres were obtained after biopsy. INTERVENTION(S):Mouse blastomeres were obtained after ...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2011.10.008

    authors： Valbuena D,Póo ME,Aguilar-Gallardo C,Martinez S,Cobo AC,Pellicer A,Simón C

    更新日期：2012-01-01 00:00:00

  • The Lupron screening test: tailoring the use of leuprolide acetate in ovarian stimulation for in vitro fertilization.

    abstract：STUDY OBJECTIVE:To evaluate the prognostic and therapeutic value of a Lupron (leuprolide acetate; Tap Pharmaceuticals, North Chicago, IL) screening test before ovarian stimulation for in vitro fertilization (IVF). DESIGN:Prospective. SETTING:Outpatient IVF program. PATIENTS:Eighty patients exhibited four early estra...

    journal_title：Fertility and sterility

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0015-0282(16)54421-5

    authors： Padilla SL,Smith RD,Garcia JE

    更新日期：1991-07-01 00:00:00

  • Random anti-Müllerian hormone (AMH) is a predictor of ovarian response in women with elevated baseline early follicular follicle-stimulating hormone levels.

    abstract：OBJECTIVE:To investigate the utility of random anti-Müllerian hormone (AMH) in assessing ovarian response among women with diminished ovarian reserve (DOR) diagnosed by elevated early follicular-phase FSH levels. DESIGN:Retrospective study. SETTING:Academic and academically affiliated assisted reproductive technology...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2011.03.071

    authors： Buyuk E,Seifer DB,Younger J,Grazi RV,Lieman H

    更新日期：2011-06-01 00:00:00

  • Comparative outcomes of hysteroscopic examinations performed after uterine artery embolization or laparoscopic uterine artery occlusion to treat leiomyomas.

    abstract：:Hysteroscopic examination of the uterine cavity revealed that patients previously treated for intramural myoma(s) by uterine artery embolization had a significantly higher incidence of abnormal findings compared with patients treated by laparoscopic occlusion of uterine arteries (59.5% vs. 2.7%). In particular, there ...

    journal_title：Fertility and sterility

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.fertnstert.2010.12.014

    authors： Kuzel D,Mara M,Horak P,Kubinova K,Maskova J,Dundr P,Cindr J

    更新日期：2011-05-01 00:00:00

  • Preimplantation genetic diagnosis does not increase pregnancy rates in patients at risk for aneuploidy.

    abstract：OBJECTIVE:To investigate the use of preimplantation genetic diagnosis (PGD) as a method for increasing pregnancy success rates in patients at high risk for aneuploidy. DESIGN:Literature review and discussion of current evidence. CONCLUSION(S):Preimplantation genetic diagnosis selects euploid embryos for transfer in a...

    journal_title：Fertility and sterility

    pub_type： 杂志文章,评审

    doi：10.1016/j.fertnstert.2005.06.045

    authors： Shahine LK,Cedars MI

    更新日期：2006-01-01 00:00:00

  • Salpingoscopy: systematic use in diagnostic laparoscopy.

    abstract：OBJECTIVE:To evaluate the importance of salpingoscopy together with laparoscopy in the diagnosis of tubal pathology. DESIGN:Salpingoscopy was performed as a complementary method in patients who were subjected to diagnostic laparoscopy. The relationship between the salpingoscopy and (1) the patient's previous history o...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(16)54952-8

    authors： Marconi G,Auge L,Sojo E,Young E,Quintana R

    更新日期：1992-04-01 00:00:00

  • Survival of the cornual pregnancy in a heterotopic gestation after in vitro fertilization and embryo transfer.

    abstract：:We present a case of combined intrauterine and cornual (interstitial) pregnancy after IVF-ET, with survival of the infant after the cornual pregnancy. The diagnosis of this rare phenomenon is difficult; a high index of suspicion and frequently ultrasound monitoring may enable early diagnosis in other forms of heteroto...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(16)53473-6

    authors： Beck P,Silverman M,Oehninger S,Muasher SJ,Acosta AA,Rosenwaks Z

    更新日期：1990-04-01 00:00:00

  • Functional differentiation in progesterone secretion by granulosa versus cumulus cells in the human preovulatory follicle and the effect of different induction of ovulation protocols.

    abstract：OBJECTIVE:To investigate P secretion by granulosa cells (GCs) versus cumulus cells derived from human preovulatory follicles. DESIGN:Cells were recovered by aspiration of preovulatory follicles in 44 women participating in an IVF program. Induction of ovulation was performed using clomiphene citrate, hMG and hCG (grou...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(16)56404-8

    authors： Dirnfeld M,Goldman S,Gonen Y,Koifman M,Lissak A,Kraiem Z,Abramovici H

    更新日期：1993-12-01 00:00:00

  • Progesterone level and progesterone/estradiol ratio on the day of hCG administration: detrimental cutoff levels and new treatment strategy.

    abstract：OBJECTIVE:To identify if there are certain cutoff levels for P and or the P/E(2) ratio on the day of hCG that would be defined as detrimental for occurrence of pregnancy in women with normal ovarian reserve undergoing cleavage-stage embryo transfer (ET). Secondarily, to determine if these same cutoffs might have the sa...

    journal_title：Fertility and sterility

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.fertnstert.2010.12.065

    authors： Elgindy EA

    更新日期：2011-04-01 00:00:00

  • Declining rates of sterilization procedures in Western Australian women from 1990 to 2008: the relationship with age, hospital type, and government policy changes.

    abstract：OBJECTIVE:To describe trends in age-specific incidence rates of female sterilization (FS) procedures in Western Australia and to evaluate the effects of the introduction of government-subsidized contraceptive methods and the implementation of the Australian government's baby bonus policy on FS rates. DESIGN:Population...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2016.04.035

    authors： Jama-Alol KA,Bremner AP,Stewart LM,Kemp-Casey A,Malacova E,Moorin R,Shirangi A,Preen DB

    更新日期：2016-09-01 00:00:00

  • Relation between the anatomical genital phenotype and cystic fibrosis transmembrane conductance regulator gene mutations in the absence of the vas deferens.

    abstract：OBJECTIVE:To study the correlation between genital phenotype and cystic fibrosis genotype in men lacking at least one vas deferens. DESIGN:Prospective study. SETTING:Institut Rhônalpin pour la Reproduction Humaine, Lyon-Bron, France. PATIENT(S):Forty-seven infertile men lacking at least one vas deferens. INTERVENTI...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(02)02954-0

    authors： Robert F,Bey-Omar F,Rollet J,Lapray JF,Morel Y

    更新日期：2002-05-01 00:00:00

  • Discovery of germ cell-specific transcripts by expressed sequence tag database analysis.

    abstract：OBJECTIVE:To identify transcripts whose expression is restricted to germ cells. DESIGN:Expressed sequence tags (ESTs) from unfertilized egg libraries were utilized to perform in silico subtraction and identify germ cell-specific transcripts. SETTING:Baylor College of Medicine, Houston, Texas. ANIMAL(S):C57BL/6J/129S...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(01)01966-5

    authors： Rajkovic A,Yan M S C,Klysik M,Matzuk M

    更新日期：2001-09-01 00:00:00

  • Laparoscopic management of hydrosalpinges before in vitro fertilization-embryo transfer: salpingectomy versus proximal tubal occlusion.

    abstract：OBJECTIVE:To compare ovarian response and IVF-ET cycle outcome in patients with hydrosalpinges managed by either laparoscopic salpingectomy or proximal tubal occlusion. DESIGN:Retrospective analysis. SETTING:Tertiary-care assisted reproductive technology program. PATIENT(S):One hundred four consecutive fresh IVF-ET ...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(00)01742-8

    authors： Surrey ES,Schoolcraft WB

    更新日期：2001-03-01 00:00:00

  • Neuroendocrine response to an intravenous L-tryptophan challenge in women with premenstrual syndrome.

    abstract：OBJECTIVE:To evaluate the neuroendocrine responses to an intravenous L-tryptophan challenge across the menstrual cycle in women with premenstrual syndrome (PMS) and controls. DESIGN:Controlled clinical study. SETTING:The Clinical Research Center of an academic research environment. PATIENT(S):Women with PMS and heal...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(99)00452-5

    authors： Rasgon N,McGuire M,Tanavoli S,Fairbanks L,Rapkin A

    更新日期：2000-01-01 00:00:00

  • The benefit of human chorionic gonadotropin supplementation throughout the secretory phase of frozen-thawed embryo transfer cycles.

    abstract：OBJECTIVE:To assess whether supplementation with hCG throughout the secretory phase of hormonally modulated cycles of frozen-thawed embryos might positively affect the outcome of such cycles. DESIGN:Prospective, randomized controlled trial. SETTING:University teaching hospital. PATIENT(S):Patients undergoing frozen-...

    journal_title：Fertility and sterility

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.fertnstert.2009.02.027

    authors： Ben-Meir A,Aboo-Dia M,Revel A,Eizenman E,Laufer N,Simon A

    更新日期：2010-02-01 00:00:00

  • Occurrence of a spontaneous luteinizing hormone surge in superovulated cycles--predictive value of serum progesterone.

    abstract：:A preovulatory increase in serum progesterone (P) precedes the occurrence of an endogenous luteinizing hormone (LH) surge in a majority of women. This study evaluates whether a single daily measurement of serum P could reliably identify a spontaneous LH surge in women undergoing controlled ovarian hyperstimulation. Ei...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(16)59654-x

    authors： Serafini P,Stone B,Kerin J,Batzofin J,Quinn P,Marrs RP

    更新日期：1988-01-01 00:00:00

  • Comparisons of inhibin B versus antimüllerian hormone in poor ovarian responders undergoing in vitro fertilization.

    abstract：OBJECTIVE:To evaluate serum inhibin B as a predictor of poor ovarian response in patients undergoing in vitro fertilization/intracytoplasmic sperm injection (IVF-ICSI) and to compare it with the performance of antimüllerian hormone (AMH). DESIGN:Meta-analysis. SETTING:University hospital. PATIENT(S):Patients undergo...

    journal_title：Fertility and sterility

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.fertnstert.2011.07.1102

    authors： Tan R,Pu D,Liu L,Liu J,Wu J

    更新日期：2011-10-01 00:00:00

  • Testicular sperm aspiration and intracytoplasmic sperm injection for persistent infection of the ejaculate.

    abstract：OBJECTIVE:To report the successful use of testicular sperm aspiration and intracytoplasmic sperm injection in the presence of an Escherichia coli-infected ejaculate that previously caused repeated embryo degeneration. DESIGN:Case report. SETTING:University medical center. PATIENT(S):A 38-year-old woman who did not c...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(98)00508-1

    authors： Seidman DS,Madjar I,Levron J,Levran D,Mashiach S,Dor J

    更新日期：1999-03-01 00:00:00

  • Characterization and mutation analysis of the human formin-2 (FMN2) gene in women with unexplained infertility.

    abstract：OBJECTIVE:Formin-2 (Fmn2) mutant mice produce oocytes with meiosis I arrest. Our aim was to describe the human FORMIN-2 (FMN2) gene and to identify DNA sequence polymorphisms in patients with unexplained infertility and multiple failed IVF cycles. DESIGN:Institutional review board-approved observational case-control s...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2004.10.051

    authors： Ryley DA,Wu HH,Leader B,Zimon A,Reindollar RH,Gray MR

    更新日期：2005-05-01 00:00:00

  • Use of augmented reality in laparoscopic gynecology to visualize myomas.

    abstract：OBJECTIVE:To report the use of augmented reality (AR) in gynecology. DESIGN:AR is a surgical guidance technology that enables important hidden surface structures to be visualized in endoscopic images. AR has been used for other organs, but never in gynecology and never with a very mobile organ like the uterus. We have...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2016.12.016

    authors： Bourdel N,Collins T,Pizarro D,Debize C,Grémeau AS,Bartoli A,Canis M

    更新日期：2017-03-01 00:00:00

  • Ovarian stimulation for in vitro fertilization and embryo transfer, human menopausal gonadotropin versus pure human follicle stimulating hormone: a randomized prospective study.

    abstract：:A randomized, prospective study was conducted to compare ovarian stimulation with human menopausal gonadotropin (hMG) and human follicle-stimulating hormone (hFSH) in an in vitro fertilization and embryo transfer (IVF-ET) program. Minimal inclusion criteria included age less than or equal to 37, tubal infertility, reg...

    journal_title：Fertility and sterility

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0015-0282(16)60011-0

    authors： Lavy G,Pellicer A,Diamond MP,DeCherney AH

    更新日期：1988-07-01 00:00:00

  • Endometriosis entrapment of the obturator nerve after previous cervical cancer surgery.

    abstract：:A 26-year-old patient underwent pelvic lymphadenectomy and trachelectomy because of cervical cancer stage IB. Later she developed symptoms from obturator nerve entrapment. Examinations could not reveal metastatic cancer disease, but endometriosis surrounding the obturator nerve was discovered. Laparoscopic removal of ...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2008.03.024

    authors： Langebrekke A,Qvigstad E

    更新日期：2009-02-01 00:00:00

  • The effects of a once-a-week steroid contraceptive (R2323) on lipid and carbohydrate metabolism in women during three months of use.

    abstract：:Forty-four women were prospectively evaluated with a 3-hour oral glucose tolerance test while they used a new weekly oral contraceptive drug, R2323. The blood tests were carried out before the drug was administered and again 3 months after its use. Both blood glucose and plasma insulin levels were measured. In the 40 ...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(16)43513-2

    authors： Spellacy WN,Buhi WC,Dumbaugh VA,Birk SA

    更新日期：1978-09-01 00:00:00

  • Successful management of an extensive intracranial sinus thrombosis in a patient undergoing IVF: case report and review of literature.

    abstract：OBJECTIVE:To report a successfully managed case of extensive intracranial sinus thrombosis that occurred during an IVF cycle, and to review the literature. DESIGN:Case report and review of literature. SETTING:University-affiliated teaching hospital. PATIENT(S):A 38-year-old nulliparous woman who developed severe ova...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2006.12.024

    authors： Edris F,Kerner CM,Feyles V,Leung A,Power S

    更新日期：2007-09-01 00:00:00

  • Investigation of the microbiota of the reproductive tract in women undergoing a total hysterectomy and bilateral salpingo-oopherectomy.

    abstract：OBJECTIVE:To conduct a pilot study to investigate the possible presence of bacteria throughout the female reproductive tract and to make a preliminary assessment of whether there are differences in the composition of the microbial communities between these body sites and/or between patients. DESIGN:Prospective pilot s...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2016.11.028

    authors： Miles SM,Hardy BL,Merrell DS

    更新日期：2017-03-01 00:00:00

  • Innovative barriers for peritoneal adhesion prevention: liquid or solid? A rat uterine horn model.

    abstract：OBJECTIVE:To compare the effects of solid barriers (PDLA membrane and foil, Interceed), innovative barrier solutions (Adept and Hyalobarrier Gel, phospholipid emulsion), and Ringer's lactate solution in preventing postsurgical peritoneal adhesions in the rat. DESIGN:Prospective, randomized experimental study. SETTING...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2006.05.023

    authors： Wallwiener M,Brucker S,Hierlemann H,Brochhausen C,Solomayer E,Wallwiener C

    更新日期：2006-10-01 00:00:00

  • Effects of progesterone, progestogens, and danazol on the specific cortisol binding in human plasma.

    abstract：:The interaction of medroxyprogesterone acetate (MPA) with cortisol binding to corticosteroid-binding globulin (CBG) was studied with the use of an aqueous two-phase system with polyethylene glycol and dextran for equilibrium partition. Competitive binding analyses were also performed for progesterone (P), levonorgestr...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(16)48612-7

    authors： Ottosson UB,Nilsson B,Södergård R,von Schoultz B

    更新日期：1985-06-01 00:00:00