Relation between the anatomical genital phenotype and cystic fibrosis transmembrane conductance regulator gene mutations in the absence of the vas deferens.


OBJECTIVE:To study the correlation between genital phenotype and cystic fibrosis genotype in men lacking at least one vas deferens. DESIGN:Prospective study. SETTING:Institut Rhônalpin pour la Reproduction Humaine, Lyon-Bron, France. PATIENT(S):Forty-seven infertile men lacking at least one vas deferens. INTERVENTION(S):All patients were screened for the 13 most common CFTR gene mutations and for the 5-thymidine variant of intron 8. Renal, scrotal, and transrectal ultrasonography were systematically performed. MAIN OUTCOME MEASURE(S):Epididymal and seminal vesicular abnormalities and testicular volume were compared among men with two, one, or no CFTR gene mutation, with or without the 5T allele. RESULTS:Seminal vesicles and the symmetry of epididymal and vesicular abnormalities did not differ between patients with and those without the CFTR gene mutation. Epididymal abnormalities were more frequent in men without the mutation. Testicular volumes were significantly lower in men without the mutation and those with the 5T allele only. CONCLUSION:Men with the CFTR mutation, the 5T allele only, and those without CFTR mutation have few differences in genital phenotype. Low testicular volume is observed in men without the CFTR mutation and those with the 5T allele only.


Fertil Steril


Fertility and sterility


Robert F,Bey-Omar F,Rollet J,Lapray JF,Morel Y





Has Abstract


2002-05-01 00:00:00














  • Ovarian reserve, response to gonadotropins, and oocyte maturity in women with malignancy.

    abstract:OBJECTIVE:To study the ovarian reserve, ovarian response to gonadotropins, and oocyte maturity in women with cancer undergoing in vitro fertilization (IVF) before chemotherapy or radiotherapy. DESIGN:Case-control study. SETTING:University teaching hospital. PATIENT(S):We evaluated all women with malignancy who under...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Das M,Shehata F,Moria A,Holzer H,Son WY,Tulandi T

    更新日期:2011-07-01 00:00:00

  • Treatment of endometriosis with the antiprogesterone mifepristone (RU486)

    abstract:OBJECTIVE:To evaluate the safety and efficacy of an antiprogesterone (mifepristone, RU486; Roussel-Uclaf, Romaineville, France) on endometriosis. DESIGN:An open, prospective clinical trial. SETTING:The clinical practice of an academic faculty. PATIENTS:Nine women with endometriosis were studied. INTERVENTIONS:RU486...

    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章


    authors: Kettel LM,Murphy AA,Morales AJ,Ulmann A,Baulieu EE,Yen SS

    更新日期:1996-01-01 00:00:00

  • Clomiphene citrate in the management of infertility associated with shortened luteal phases.

    abstract::Repetitively short luteal phases were found in eight infertile women. The short luteal phase was defined as 10 days or less from the presumed time of ovulation (as assessed by basal body temperature recording) to the onset of menses. Clomiphene citrate (Clomid) therapy resulted in pregnancy in two patients and lengthe...

    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章


    authors: Quagliarello J,Weiss G

    更新日期:1979-04-01 00:00:00

  • Is chromosome testing of the second miscarriage cost saving? A decision analysis of selective versus universal recurrent pregnancy loss evaluation.

    abstract:OBJECTIVE:To compare the cost of selective recurrent pregnancy loss (RPL) evaluation, which is defined as RPL evaluation if the second miscarriage is euploid, versus universal RPL evaluation, which is defined as RPL evaluation after the second miscarriage. Traditionally, an RPL evaluation is instituted after the third ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Bernardi LA,Plunkett BA,Stephenson MD

    更新日期:2012-07-01 00:00:00

  • Blood leukocyte subsets are modulated in patients with endometriosis.

    abstract:OBJECTIVE:To determine whether blood leukocyte populations could be modulated in endometriosis. DESIGN:Case-control study. SETTING:Eight clinical institutions of the Montreal area. PATIENT(S):Women with regular menstrual cycles who underwent laparoscopy or laparotomy between 1997 and 2001 and who were not under horm...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Gagné D,Rivard M,Pagé M,Shazand K,Hugo P,Gosselin D

    更新日期:2003-07-01 00:00:00

  • The immune response during the luteal phase of the ovarian cycle: a Th2-type response?

    abstract:OBJECTIVE:To test the hypothesis that during the luteal phase of the ovarian cycle, as compared with the follicular phase, the peripheral immune response is shifted toward a type-2 response. DESIGN:Prospective study. SETTING:Academic research setting. PATIENT(S):Women with regular menstrual cycles. INTERVENTION(S):...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Faas M,Bouman A,Moesa H,Heineman MJ,de Leij L,Schuiling G

    更新日期:2000-11-01 00:00:00

  • Combined screening laparoscopy and timed follicle aspiration for human in vitro fertilization.

    abstract::Twenty-seven patients underwent ultrasonographic and clinical monitoring of a spontaneous cycle so that human chorionic gonadotropin administration could be timed in an attempt to schedule the screening laparoscopy at the optimal time for oocyte aspiration. Inadequate ovarian access was encountered in only 2 of 26 lap...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Wentz AC,Torbit CA,Daniell JF,Fleischer AC,Garner CH,Pittaway DE,Christianson CD,Repp JE,Maxson WS

    更新日期:1983-03-01 00:00:00

  • Hepatic lipase activity during oral and parenteral 17 beta-estradiol replacement therapy: high-density lipoprotein increase may not be antiatherogenic.

    abstract:OBJECTIVE:Hepatic lipase activity is involved in the removal of cholesterol and phospholipid from plasma high-density lipoprotein (HDL) to the liver. Changes in hepatic lipase are responsible for some lipoprotein modifications observed during estrogen administration (i.e., increased HDL levels). The aim of this study w...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Basdevant A,de Lignieres B,Simon P,Blache D,Ponsin G,Guy-Grand B

    更新日期:1991-06-01 00:00:00

  • The International Endogene Study: a collection of families for genetic research in endometriosis.

    abstract:OBJECTIVE:The aim of the International Endogene Study is to discover genes that influence susceptibility to endometriosis. DESIGN:The study brings together two research groups based in Australia and the United Kingdom that independently have been collecting families for linkage analysis and candidate gene studies. Bot...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Treloar S,Hadfield R,Montgomery G,Lambert A,Wicks J,Barlow DH,O'Connor DT,Kennedy S,International Endogene Study Group.

    更新日期:2002-10-01 00:00:00

  • How couples who have undergone in vitro fertilization decide what to do with surplus frozen embryos.

    abstract::In a qualitative interview study of 77 families with stored frozen embryos, we found that while embryo disposition decision making was influenced by individual life circumstances, embryo quantity/quality, personal values, embryo conceptualization, and clinic information, it was a stepwise process that could be represe...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Nachtigall RD,Mac Dougall K,Harrington J,Duff J,Lee M,Becker G

    更新日期:2009-12-01 00:00:00

  • Ovarian pregnancy resulting from cornual fistulae in a woman who had undergone bilateral salpingectomy.

    abstract:OBJECTIVE:To report a case of ovarian pregnancy following in vitro fertilization-embryo transfer (IVF-ET) treatment for which the cornual fistulae was the most probable explanation of the cause. DESIGN:Case report. SETTING:University department and assisted reproduction unit. PATIENT(S):A 29-year-old woman with prim...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Hsu CC,Yang TT,Hsu CT

    更新日期:2005-01-01 00:00:00

  • Assessment of female sexual dysfunction: review of validated methods.

    abstract:OBJECTIVE:To review validated methods for the assessment of female sexual function in clinical trials. DESIGN:Evaluation of recent peer-review literature on sexual function assessment in women. SETTING:International conference on androgen insufficiency in women. PATIENT(S):Women with sexual dysfunction due to androg...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,评审


    authors: Rosen RC

    更新日期:2002-04-01 00:00:00

  • Ectopic growth of endometrium depends on its structural integrity and proteolytic activity in the cynomolgus monkey (Macaca fascicularis) model of endometriosis.

    abstract:OBJECTIVE:To identify factors influencing the development of endometrial autografts in a monkey model of endometriosis. DESIGN:Prospective, comparative study. SETTING:Animal research unit. SUBJECTS:Thirty regularly cycling cynomolgus monkeys in three groups of 10 each. INTERVENTIONS:Endometrium was minced and spill...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Sillem M,Hahn U,Coddington CC 3rd,Gordon K,Runnebaum B,Hodgen GD

    更新日期:1996-09-01 00:00:00

  • A comparison study of a novel stimulation protocol and the conventional low dose step-up and step-down regimens in patients with polycystic ovary syndrome undergoing in vitro fertilization.

    abstract:OBJECTIVE:To compare the efficacy of a sequential step-up/step-down protocol with the conventional low dose step-up and the step-down regimens in patients with polycystic ovary syndrome (PCOS) undergoing IVF. DESIGN:Prospective randomized study. SETTING:Private fertility clinic. PATIENT(S):Two hundred twenty-five, 3...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,随机对照试验


    authors: Koundouros SN

    更新日期:2008-09-01 00:00:00

  • Effect of short-term hormone replacement therapy on left ventricular mass and contractile function.

    abstract:OBJECTIVE:To determine the effect of hormone replacement therapy (HRT) on cardiac structure and function and whether these changes are related to changes in blood volume. DESIGN:Open-label pilot study. SETTING:Academic medical center. PATIENT(S):Eighteen healthy postmenopausal women. INTERVENTION(S):We administered...

    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章


    authors: Sites CK,Tischler MD,Blackman JA,Niggel J,Fairbank JT,O'Connell M,Ashikaga T

    更新日期:1999-01-01 00:00:00

  • Can intracytoplasmic morphologically selected sperm injection be used to select normal-sized sperm heads in infertile patients with macrocephalic sperm head syndrome?

    abstract:OBJECTIVE:To study the chromosomal content of spermatozoa selected by intracytoplasmic morphologically selected sperm injection (IMSI) in cases of macrocephalic sperm head syndrome. DESIGN:Case report. SETTING:Obstetrics, gynecology, urology, and reproductive biology departments. PATIENT(S):Two infertile patients wi...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Chelli MH,Albert M,Ray PF,Guthauser B,Izard V,Hammoud I,Selva J,Vialard F

    更新日期:2010-03-01 00:00:00

  • Cumuli oophori in tissue culture: hormone production, ultrastructure, and morphometry of early luteinization.

    abstract::The steroidogenic activity of cumulus oophorus granulosa cells obtained from unstimulated rabbits in estrus has been investigated at closely timed intervals in short-term cultures. The presence of viable, structurally well preserved oocytes and the addition of large follicle follicular fluid had no apparent inhibitory...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Nicosia SV,Mikhail G

    更新日期:1975-05-01 00:00:00

  • Clinical application of comprehensive chromosomal screening at the blastocyst stage.

    abstract:OBJECTIVE:To evaluate a new strategy for comprehensive chromosome screening at the blastocyst stage. DESIGN:Clinical research study. SETTING:An IVF clinic and a specialist preimplantation genetic diagnosis laboratory. PATIENT(S):Forty-five infertile couples participated in the study. The mean maternal age was 37.7 y...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Schoolcraft WB,Fragouli E,Stevens J,Munne S,Katz-Jaffe MG,Wells D

    更新日期:2010-10-01 00:00:00

  • Insights from gene arrays on the development and growth regulation of uterine leiomyomata.

    abstract:OBJECTIVE:To use microarray analysis as an unbiased approach to identify genes involved in the induction and growth of uterine leiomyomata. DESIGN:Screen by arrays for up to 12,000 genes in leiomyoma (L) and control myometrium (M) from nine patients. SETTING:University research laboratories. PATIENT(S):Nine patients...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Tsibris JC,Segars J,Coppola D,Mane S,Wilbanks GD,O'Brien WF,Spellacy WN

    更新日期:2002-07-01 00:00:00

  • Identification of a uteroglobin-like antigen in human uterine washings.

    abstract::A uteroglobin-like molecule was detected with a sensitive radioimmunoassay for rabbit uteroglobin in the uterine washings of women. This antigen was detectable only in small amounts in the uterine washings obtained from women in the late luteal phase or proliferative phase, but was detected in large amounts in uterine...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Cowan BD,North DH,Whitworth NS,Fujita R,Shumacher EK,Mukherjee AB

    更新日期:1986-06-01 00:00:00

  • Gross and histopathologic effects of medroxyprogesterone acetate and progesterone on the mammary glands of adult beagle bitches.

    abstract::Adult beagle bitches received 0.2 to 75 mg/kg doses of medroxyprogesterone acetate (MPA) once every 3 months for 1 to 1.5 years. Doses greater than 2.0 mg/kg prevented the recurrence of ovarian cycles; lower doses did not. MPA (10 and 75 mg/kg) induced a dose-related development of multiple, large (greater than 5 mm d...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Concannon PW,Spraker TR,Casey HW,Hansel W

    更新日期:1981-09-01 00:00:00

  • Risk of type 2 diabetes is increased in nonobese women with polycystic ovary syndrome: the National Health Insurance Service-National Sample Cohort Study.

    abstract:OBJECTIVE:To investigate the relationship between polycystic ovary syndrome (PCOS) and type 2 diabetes mellitus (T2DM) in Korean women. DESIGN:Longitudinal case-control study. SETTING:Not applicable. PATIENT(S):PCOS patients aged 15 to 44 years (n = 1,136) and control individuals (n = 5,675), matched 1:5 by age grou...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Ryu KJ,Kim MS,Kim HK,Kim YJ,Yi KW,Shin JH,Hur JY,Kim T,Park H

    更新日期:2021-01-25 00:00:00

  • One thousand initiated cycles of in vitro fertilization in women > or = 40 years of age.

    abstract:OBJECTIVE:To evaluate the results of IVF in women > or = 40 years of age using their own oocytes. DESIGN:Retrospective study. SETTING:Wolfson and Royal Masonic in vitro fertilization units, London, United Kingdom. PATIENT(S):A total of 1,087 IVF cycles were started in women > or = 40 years of age. INTERVENTION(S):M...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Lass A,Croucher C,Duffy S,Dawson K,Margara R,Winston RM

    更新日期:1998-12-01 00:00:00

  • Embryo morphology and development are dependent on the chromosomal complement.

    abstract:OBJECTIVE:To analyze embryo morphology in relation to the corresponding chromosomal status, in order to evaluate the effects of aneuploidy over fragmentation, delayed cleavage, and arrested cleavage. DESIGN:Retrospective study. SETTING:Reproductive Medicine Unit, Società Italiana di Studi di Medicina della Riproduzio...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Magli MC,Gianaroli L,Ferraretti AP,Lappi M,Ruberti A,Farfalli V

    更新日期:2007-03-01 00:00:00

  • Pink or blue? The need for regulation is black and white.

    abstract::A new direct-to-consumer genetic test purports to detect fetal gender as early as five weeks of pregnancy. The availability of this test highlights the consequences of the current system of oversight for genetic tests and underscores the need for an enhanced regulatory framework to ensure the accuracy, reliability, an...

    journal_title:Fertility and sterility

    pub_type: 社论


    authors: Javitt GH

    更新日期:2006-07-01 00:00:00

  • A steroid cell tumor outside the ovary is a rare cause of virilization.

    abstract:OBJECTIVE:To report the case of a female who presented in childhood with symptoms and signs of hyperandrogenism secondary to an extraovarian steroid cell tumor. DESIGN:Case report. SETTING:Endocrine investigation unit of a university teaching hospital. PATIENT(S):An 11-year-old female presented with symptoms and sig...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Smith D,Crotty TB,Murphy JF,Crofton ME,Franks S,McKenna TJ

    更新日期:2006-01-01 00:00:00

  • Protein, progesterone, and protease inhibitors in uterine and peritoneal fluids of women with endometriosis.

    abstract::This study was undertaken to determine whether women with endometriosis have altered protein, progesterone (P), and protease inhibitor concentrations in their uterine fluid and peritoneal fluid (PF) compared with controls at different phases of the menstrual cycle. Uterine flushings (UFs), PF, and blood were obtained ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Fazleabas AT,Khan-Dawood FS,Dawood MY

    更新日期:1987-02-01 00:00:00

  • Lack of standardization in performance of the semen analysis among laboratories in the United States.

    abstract:OBJECTIVE:To determine the level of standardization in performance of the semen analysis among clinical laboratories in the United States. DESIGN:A survey was mailed to laboratories requesting information about the laboratory and performance of the semen analysis. Responses were received from 536 laboratories. SETTIN...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Keel BA,Stembridge TW,Pineda G,Serafy NT Sr

    更新日期:2002-09-01 00:00:00

  • Effects of low-dose estrogen oral contraceptives on weight, body composition, and fat distribution in young women.

    abstract:OBJECTIVE:To determine prospectively whether the use of low-dose estrogen oral contraceptives (OC) is associated with changes in weight, body composition, or fat distribution. DESIGN:Anthropometric measurements were performed in 49 healthy young (16 to 21 years old) women before commencement of OC use (30 micrograms e...

    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章


    authors: Reubinoff BE,Grubstein A,Meirow D,Berry E,Schenker JG,Brzezinski A

    更新日期:1995-03-01 00:00:00

  • Subfertility increases risk of testicular cancer: evidence from population-based semen samples.

    abstract:OBJECTIVE:To further understand the association between semen quality and cancer risk by means of well defined semen parameters. DESIGN:Retrospective cohort study. SETTING:Not applicable. PATIENT(S):A total of 20,433 men who underwent semen analysis (SA) and a sample of 20,433 fertile control subjects matched by age...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Hanson HA,Anderson RE,Aston KI,Carrell DT,Smith KR,Hotaling JM

    更新日期:2016-02-01 00:00:00