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The benefit of human chorionic gonadotropin supplementation throughout the secretory phase of frozen-thawed embryo transfer cycles.

Abstract：

OBJECTIVE:To assess whether supplementation with hCG throughout the secretory phase of hormonally modulated cycles of frozen-thawed embryos might positively affect the outcome of such cycles. DESIGN:Prospective, randomized controlled trial. SETTING:University teaching hospital. PATIENT(S):Patients undergoing frozen-thawed embryo transfer cycles. INTERVENTION(S):Patients were randomly divided into two groups by the last digit of their identification number. Group A received our standard protocol for endometrial preparation, whereas group B patients were given an additional 250 microg of recombinant hCG on day of P initiation, the day of embryo transfer, and 6 days later. Throughout the cycle, and to compare between the groups, serial ultrasound examinations and hormonal tests of E(2) and P serum levels were obtained. MAIN OUTCOME MEASURE(S):Implantation and clinical pregnancy rates (PR). RESULT(S):One hundred sixty-five patients were enrolled in this study, 78 in the control group and 87 in the hCG-treated group. Progesterone levels and endometrial thickness were similar throughout the cycle in both groups. The E(2) level was significantly higher in group B on the day of embryo transfer and 6 days later. The PRs did not differ between the two groups (28.2% and 32.2% for groups A and B, respectively). Similarly, the implantation rates were comparable between the groups (12.7% and 14.9%, respectively). CONCLUSION(S):No advantage was found concerning PR and implantation rate by supplementing the secretory phase with hCG in patients undergoing transfer of frozen-thawed embryo in hormonally modulated cycles.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Ben-Meir A,Aboo-Dia M,Revel A,Eizenman E,Laufer N,Simon A

doi

10.1016/j.fertnstert.2009.02.027

subject

Has Abstract

pub_date

2010-02-01 00:00:00

pages

351-4

issue

2

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(09)00370-7

journal_volume

93

pub_type

杂志文章,随机对照试验

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