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Increased expression of c-fos protein associated with increased matrix metalloproteinase-9 protein expression in the endometrium of endometriotic patients.

Abstract：

OBJECTIVE:To investigate c-fos and matrix metalloproteinase-9 (MMP-9) expression in the endometrium from women with or without endometriosis throughout the menstrual cycle, and to explore the correlation of c-fos expression with MMP-9 expression and 17beta-E(2) levels in serum. DESIGN:Molecular studies in human tissue. SETTING:A women's hospital in China. PATIENT(S):Fifty-five premenopausal women (25 with endometriosis and 30 without endometriosis) undergoing laparoscopic surgery or hysterectomy. INTERVENTION(S):Eutopic and ectopic endometrium tissue were obtained at the time of surgery. Peripheral sera were also collected on the same day. MAIN OUTCOME MEASURE(S):Immunohistochemical localization of c-fos in the endometrium, c-fos and MMP-9 protein levels in the endometrium, and 17beta-E(2) levels in the serum. RESULT(S):c-fos protein was predominantly located in the nuclei of glandular epithelial cells and stromal cells. c-fos and MMP-9 protein levels in paired eutopic and ectopic endometria from women with endometriosis were significantly higher than those in the endometrium from women without endometriosis. No significant difference in c-fos or MMP-9 protein levels was observed between paired eutopic and ectopic endometria. c-fos protein levels in endometrium positively correlated with endometrial MMP-9 levels and serum 17beta-E(2) levels. CONCLUSION(S):Expression of c-fos in the human endometrium may be regulated by 17beta-E(2), and c-fos may be involved in development of endometriosis by promoting MMP-9 gene expression and subsequently the invasive potential of endometrial explants.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Pan H,Sheng JZ,Tang L,Zhu R,Zhou TH,Huang HF

doi

10.1016/j.fertnstert.2007.07.1386

subject

Has Abstract

pub_date

2008-10-01 00:00:00

pages

1000-7

issue

4

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(07)03043-9

journal_volume

90

pub_type

杂志文章

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