Abstract:
OBJECTIVE:To determine whether cryptorchidism associated with azoospermia or oligozoospermia may be due to microdeletions of the Y chromosome. DESIGN:Controlled clinical study. SETTINGS:Division of Medical Genetics and the Andrology Centre, Department of Obstetrics and Gynecology, University Medical Center, Ljubljana. PATIENT(S):Ninety men from infertile couples (36 azoospermics, 35 oligozoospermics, and 19 normozoospermics) with a medical history of cryptorchidism. Nineteen excryptorchid patients with cryptorchidism and Y chromosome microdeletions among 3099 patients from 14 publications. INTERVENTION(S):Collection of semen and blood samples. MAIN OUTCOME MEASURE(S):Medical history, testicular volume, sperm characteristics, serum FSH levels, testicular histology, presence or absence of Y chromosome microdeletions, including all known Y chromosome genes/gene families in the azoospermia factor (AZF) region. RESULT(S):Deletions of the Y chromosome were found in 2 out of 71 cryptorchid patients with azoospermia or oligozoospermia (2.8%). The literature review showed that the incidence of microdeletions in infertile patients with cryptorchidism is lower in comparison with the general population of infertile men (4.9% vs. 8.1%), and that the frequency of cryptorchidism in patients with Y chromosome deletions (6 out of 103, 5.8%) is significantly lower in comparison to infertile patients without deletions (178 out of 1141, 15.6%). CONCLUSION(S):No causal relation exists between Y chromosome microdeletions and cryptorchidism.
journal_name
Fertil Steriljournal_title
Fertility and sterilityauthors
Kunej T,Zorn B,Peterlin Bdoi
10.1016/s0015-0282(03)00375-3keywords:
subject
Has Abstractpub_date
2003-06-01 00:00:00pages
1559-65eissn
0015-0282issn
1556-5653pii
S0015028203003753journal_volume
79 Suppl 3pub_type
杂志文章abstract:OBJECTIVE:To evaluate the effect of growth differentiation factor-9 (GDF-9) and bone morphogenetic protein-15 (BMP-15) on the development of follicles among patients with polycystic ovary syndrome (PCOS). DESIGN:Case-control study. SETTING:University Hospital. PATIENT(S):Twenty-two oocytes were obtained from 15 pati...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2009.03.014
更新日期:2010-06-01 00:00:00
abstract:OBJECTIVE:To compare ovarian performance and hormonal levels, after ovulation induction, in patients with isolated hypogonadotropic hypogonadism, using two different gonadotropin drugs. DESIGN:Patients were treated during consecutive cycles, using the same stimulation protocol, with human menopausal gonadotropin (hMG)...
journal_title:Fertility and sterility
pub_type: 临床试验,杂志文章
doi:10.1016/s0015-0282(16)54715-3
更新日期:1991-12-01 00:00:00
abstract:OBJECTIVE:To determine the impact of hydrosalpinx on pregnancy rates in patients undergoing IVF for infertility caused by tubal disease. DESIGN:Review of the records of all patients who had undergone IVF for tubal factor infertility at our institution between May 1988 and October 1994. SETTING:A university-sponsored,...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(97)80079-9
更新日期:1997-03-01 00:00:00
abstract:OBJECTIVE:The purpose of the study was to describe and to compare the rate of rise of human chorionic gonadotropin (hCG) in vanishing twin and normally progressing twin pregnancies during the first trimester. DESIGN:All patients with twin pregnancies between 1985 and 1989 were prospectively studied. Human chorionic go...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)54475-6
更新日期:1991-08-01 00:00:00
abstract:OBJECTIVE:To evaluate tubal morphology, trophoblast proliferation, and inflammatory reaction in response to methotrexate (MTX) treatment of ectopic pregnancy (EP). DESIGN:Nonrandomized controlled study. SETTING:Academic hospital. PATIENTS:Archival specimens from 10 EP unsuccessfully treated with MTX and 10 cases pri...
journal_title:Fertility and sterility
pub_type: 临床试验,杂志文章
doi:
更新日期:1996-04-01 00:00:00
abstract:OBJECTIVE:To determine the effect of moderate alcohol intake on probability of conception. DESIGN:Prospective cohort study. SETTING:Normal healthy women enrolled in an artificial donor insemination program. PATIENTS:Women starting artificial donor insemination for the very first time were selected. INTERVENTIONS:Al...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)57056-3
更新日期:1994-11-01 00:00:00
abstract:OBJECTIVE:To report a case of parasitic leiomyoma of the abdominal wall after laparoscopic myomectomy. DESIGN:Case report. SETTING:Large medical center. PATIENT(S):A 31-year-old woman with a newly developed palpable mass in the abdominal wall near the trocar site of a previous laparoscopic myomectomy. INTERVENTION(...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2007.08.068
更新日期:2008-10-01 00:00:00
abstract:OBJECTIVE:To study the correlation between the incidence of sex chromosome aneuploidies in the somatic cells and spermatozoa in karyotypically normal infertile men and fertile donors. DESIGN:A prospective, phase two, controlled study. SETTING:A teaching Hospital Reproductive Medicine and Medical Genetics Units. PATI...
journal_title:Fertility and sterility
pub_type: 临床试验,杂志文章
doi:10.1016/s0015-0282(00)00603-8
更新日期:2000-08-01 00:00:00
abstract:OBJECTIVE:To summarize the available published randomized controlled trial data regarding timing of P supplementation during the luteal phase of patients undergoing assisted reproductive technology (ART). DESIGN:A systematic review. SETTING:Not applicable. PATIENT(S):Undergoing IVF. INTERVENTION(S):Different starti...
journal_title:Fertility and sterility
pub_type: 杂志文章,评审
doi:10.1016/j.fertnstert.2014.12.125
更新日期:2015-04-01 00:00:00
abstract:OBJECTIVE:To evaluate whether stimulation of endometrium embryo transfer (SEET) can improve implantation rate and pregnancy rate (PR) for patients undergoing assisted reproductive technology (ART) for the first time by injecting embryo culture supernatant into the uterus before blastocyst transfer (BT). DESIGN:Randomi...
journal_title:Fertility and sterility
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.fertnstert.2008.08.076
更新日期:2009-10-01 00:00:00
abstract:OBJECTIVE:To test the hypothesis that during the luteal phase of the ovarian cycle, as compared with the follicular phase, the peripheral immune response is shifted toward a type-2 response. DESIGN:Prospective study. SETTING:Academic research setting. PATIENT(S):Women with regular menstrual cycles. INTERVENTION(S):...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(00)01553-3
更新日期:2000-11-01 00:00:00
abstract::We hypothesized that diminished endothelin 1 (ET-1) expression at the spermatic vein wall level might be responsible for the development of varicocele. However, immunohistochemical evaluation of spermatic and control vein samples from 55 patients with varicocele showed overexpression of ET-1 and its receptors ETA and ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2011.04.062
更新日期:2011-06-30 00:00:00
abstract:OBJECTIVE:To perform a cost-benefit analysis of preimplantation genetic diagnosis (PGD) for carrier couples of cystic fibrosis (CF) compared with the alternative of natural conception (NC) followed by prenatal testing and termination of affected pregnancies. DESIGN:Cost-benefit analysis using a decision analytic model...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2008.12.053
更新日期:2010-04-01 00:00:00
abstract::Danazol was found to possess androgenic and glucocorticoid activity in rat bioassays. In contrast, danazol displayed no significant estrogenic activity. In support of these findings, danazol bound to the 8 S androgen receptor of rat prostate cytosol and to the glucocorticoid receptor of rat liver cytosol, but danazol ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)43820-3
更新日期:1979-02-01 00:00:00
abstract::The predictive value of the metoclopramid-provocation test to detect transient hyperprolactinemia during cycle stimulation was assessed. Patients developing hyperprolactinemia during cycle stimulation showed a significantly higher PRL response to the metoclopramid-provocation test before cycle stimulation. The current...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)53300-7
更新日期:1990-02-01 00:00:00
abstract:OBJECTIVE:To evaluate the occurrence of mutations of 5alpha-reductase type 2 gene in patients with cryptorchidism or idiopathic azoospermia. DESIGN:Controlled clinical study. SETTING:Yamagata University Hospital, Yamagata and Tokyo Electric Power Company Hospital, Tokyo, Japan. PATIENT(S):Patients with isolated cryp...
journal_title:Fertility and sterility
pub_type: 临床试验,杂志文章
doi:10.1016/s0015-0282(02)03220-x
更新日期:2002-08-01 00:00:00
abstract:OBJECTIVE:To assess bacterial colonization following balloon uterine stent placement in the uterus for 30 days. DESIGN:Prospective randomized controlled study. SETTING:Tertiary medical center. PATIENT(S):Sixty-eight women scheduled for hysteroscopy. INTERVENTION(S):Women who were undergoing hysteroscopic surgery we...
journal_title:Fertility and sterility
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.fertnstert.2014.10.032
更新日期:2015-02-01 00:00:00
abstract::Expanded carrier screening refers to identification of carriers of single-gene disorders outside of traditional screening guidelines. New genetic testing technologies allow for such screening at costs that are comparable to single-gene testing. There is a high degree of variability among genetic testing laboratories a...
journal_title:Fertility and sterility
pub_type: 杂志文章,评审
doi:10.1016/j.fertnstert.2017.11.030
更新日期:2018-02-01 00:00:00
abstract:OBJECTIVE:To study the differences in the cleavage time between types of embryo chromosomal abnormalities and elaborate algorithm to exclude aneuploid embryos according to the likelihood to be euploid. DESIGN:Retrospective cohort study. SETTING:University affiliated private center. PATIENT(S):Preimplantational genet...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2016.09.019
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVE:To investigate whether proteins secreted in urine differ between women with and without endometriosis. DESIGN:Laboratory study using human urine. SETTING:University-based laboratory. PATIENT(S):Women with and without endometriosis undergoing laparoscopy, hysteroscopy and curettage. INTERVENTION(S):Urine c...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2010.05.016
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVE:To evaluate the results of IVF in women > or = 40 years of age using their own oocytes. DESIGN:Retrospective study. SETTING:Wolfson and Royal Masonic in vitro fertilization units, London, United Kingdom. PATIENT(S):A total of 1,087 IVF cycles were started in women > or = 40 years of age. INTERVENTION(S):M...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(98)00353-7
更新日期:1998-12-01 00:00:00
abstract:OBJECTIVE:To determine the efficiency of oocyte retrieval (OR) timing based on the occurrence of spontaneous LH surge during natural cycle IVF (ncIVF) treatment. DESIGN:Retrospective cohort study. The cohort was divided into five subgroups according to the presumed stage of spontaneous LH surge on scheduling day (1A: ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2014.01.016
更新日期:2014-04-01 00:00:00
abstract::We have microsurgically extracted a pronucleus from 11 tripronuclear human zygotes under two different experimental conditions. One group of six zygotes was incubated in cytochalasin D for 30 minutes before manipulation. The remaining five zygotes were manipulated without preincubation in cytoskeletal relaxing agents....
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)60901-9
更新日期:1989-09-01 00:00:00
abstract:OBJECTIVE:To present an unusual side effect of therapy for adolescent menorrhagia, with commentary on management options. DESIGN:Case report. SETTING:Tertiary gynecologic center. PATIENT(S):A 13-year-old girl presenting with profuse uterine bleeding. INTERVENTION(S):Dysfunctional uterine bleeding was diagnosed, and...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2009.07.997
更新日期:2009-11-01 00:00:00
abstract:OBJECTIVE:To compare oocyte maturation, fertilization and cleavage rates, and embryonic developmental quality after culture of human immature oocytes from polycystic ovary syndrome (PCOS) patients in human tubal fluid (HTF) or tissue culture medium (TCM) 199. DESIGN:Prospective, randomized, controlled trial. SETTING:...
journal_title:Fertility and sterility
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.fertnstert.2007.11.082
更新日期:2009-02-01 00:00:00
abstract:OBJECTIVE:Formin-2 (Fmn2) mutant mice produce oocytes with meiosis I arrest. Our aim was to describe the human FORMIN-2 (FMN2) gene and to identify DNA sequence polymorphisms in patients with unexplained infertility and multiple failed IVF cycles. DESIGN:Institutional review board-approved observational case-control s...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2004.10.051
更新日期:2005-05-01 00:00:00
abstract:OBJECTIVE:To determine the contribution of several variables to fluid loss during transcervical resection of submucous myomas. DESIGN:An observational study using multiple linear regression analyses. SETTING:A university-affiliated training hospital and a university department of clinical epidemiology and biostatisti...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(97)00335-x
更新日期:1997-11-01 00:00:00
abstract:OBJECTIVE:To critically examine ovarian reserve testing before assisted reproduction. DESIGN:A PUBMED computer search to identify relevant literature. SETTING:Multiple sites. PATIENT(S):Patients undergoing assisted reproduction. INTERVENTION(S):Testing for ovarian reserve. MAIN OUTCOME MEASURE(S):Assisted reproduc...
journal_title:Fertility and sterility
pub_type: 杂志文章,评审
doi:10.1016/j.fertnstert.2007.10.080
更新日期:2008-12-01 00:00:00
abstract:OBJECTIVE:To determine the fertility potential of women with congenital ampullary atresia of the fallopian tube. DESIGN:Case report and review of literature. SETTING:University-affiliated tertiary care infertility clinic. PATIENT(S):Six infertile women with congenital ampullary atresia of the oviduct. INTERVENTION(...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(02)04691-5
更新日期:2003-02-01 00:00:00
abstract::Since the late 1980s premature progesterone elevation has repeatedly caught the attention of investigators, not only for its importance, but also because studies have shown differing results and conclusions, constituting an unexplainable sequence of doubts and uncertainties. This issue's Views and Reviews section seek...
journal_title:Fertility and sterility
pub_type:
doi:10.1016/j.fertnstert.2018.02.134
更新日期:2018-04-01 00:00:00