Y chromosome microdeletions in infertile men with cryptorchidism.

Abstract:

OBJECTIVE:To determine whether cryptorchidism associated with azoospermia or oligozoospermia may be due to microdeletions of the Y chromosome. DESIGN:Controlled clinical study. SETTINGS:Division of Medical Genetics and the Andrology Centre, Department of Obstetrics and Gynecology, University Medical Center, Ljubljana. PATIENT(S):Ninety men from infertile couples (36 azoospermics, 35 oligozoospermics, and 19 normozoospermics) with a medical history of cryptorchidism. Nineteen excryptorchid patients with cryptorchidism and Y chromosome microdeletions among 3099 patients from 14 publications. INTERVENTION(S):Collection of semen and blood samples. MAIN OUTCOME MEASURE(S):Medical history, testicular volume, sperm characteristics, serum FSH levels, testicular histology, presence or absence of Y chromosome microdeletions, including all known Y chromosome genes/gene families in the azoospermia factor (AZF) region. RESULT(S):Deletions of the Y chromosome were found in 2 out of 71 cryptorchid patients with azoospermia or oligozoospermia (2.8%). The literature review showed that the incidence of microdeletions in infertile patients with cryptorchidism is lower in comparison with the general population of infertile men (4.9% vs. 8.1%), and that the frequency of cryptorchidism in patients with Y chromosome deletions (6 out of 103, 5.8%) is significantly lower in comparison to infertile patients without deletions (178 out of 1141, 15.6%). CONCLUSION(S):No causal relation exists between Y chromosome microdeletions and cryptorchidism.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Kunej T,Zorn B,Peterlin B

doi

10.1016/s0015-0282(03)00375-3

keywords:

subject

Has Abstract

pub_date

2003-06-01 00:00:00

pages

1559-65

eissn

0015-0282

issn

1556-5653

pii

S0015028203003753

journal_volume

79 Suppl 3

pub_type

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