Y chromosome microdeletions in infertile men with cryptorchidism.


OBJECTIVE:To determine whether cryptorchidism associated with azoospermia or oligozoospermia may be due to microdeletions of the Y chromosome. DESIGN:Controlled clinical study. SETTINGS:Division of Medical Genetics and the Andrology Centre, Department of Obstetrics and Gynecology, University Medical Center, Ljubljana. PATIENT(S):Ninety men from infertile couples (36 azoospermics, 35 oligozoospermics, and 19 normozoospermics) with a medical history of cryptorchidism. Nineteen excryptorchid patients with cryptorchidism and Y chromosome microdeletions among 3099 patients from 14 publications. INTERVENTION(S):Collection of semen and blood samples. MAIN OUTCOME MEASURE(S):Medical history, testicular volume, sperm characteristics, serum FSH levels, testicular histology, presence or absence of Y chromosome microdeletions, including all known Y chromosome genes/gene families in the azoospermia factor (AZF) region. RESULT(S):Deletions of the Y chromosome were found in 2 out of 71 cryptorchid patients with azoospermia or oligozoospermia (2.8%). The literature review showed that the incidence of microdeletions in infertile patients with cryptorchidism is lower in comparison with the general population of infertile men (4.9% vs. 8.1%), and that the frequency of cryptorchidism in patients with Y chromosome deletions (6 out of 103, 5.8%) is significantly lower in comparison to infertile patients without deletions (178 out of 1141, 15.6%). CONCLUSION(S):No causal relation exists between Y chromosome microdeletions and cryptorchidism.


Fertil Steril


Fertility and sterility


Kunej T,Zorn B,Peterlin B





Has Abstract


2003-06-01 00:00:00










79 Suppl 3


  • Gamete donation: a question of anonymity.

    abstract::The key global issue surrounding gamete donation is not the well-rehearsed known vs. anonymous donation argument but rather one of providing patients with a flexible dual-track system (i.e., ability to know or not to know donor identity), complete with psychosocial support and education that enables them to make well-...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: De Jonge C,Barratt CL

    更新日期:2006-02-01 00:00:00

  • Incomplete and inconsistent reporting of maternal and fetal outcomes in infertility treatment trials.

    abstract::Pregnancy outcomes and adverse outcomes in infertility trials are reported to varying extents; for example, 35% of clinical trials reported no information on pregnancy loss, only 43% reported adverse events during the preconception treatment period, and only 7% reported any serious adverse events. Incomplete reporting...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,评审


    authors: Dapuzzo L,Seitz FE,Dodson WC,Stetter C,Kunselman AR,Legro RS

    更新日期:2011-06-30 00:00:00

  • Immunolocalization of a sperm membrane protein in human male reproductive organs.

    abstract::A monoclonal antibody that induces agglutination of human sperm was used to localize the interacting antigen in various tissues by indirect immunofluorescence. The antibody localized to the immature sperm and Sertoli cells of the seminiferous tubules, simple cuboidal epithelial cells of the rete testis, and the column...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Yan YC,Mitsudo SM,Wang LF,Koide SS

    更新日期:1984-10-01 00:00:00

  • An observational study of women with müllerian agenesis and their need for vaginal dilator therapy.

    abstract:OBJECTIVE:To assess vaginal development, sexual activity, and the efficacy of vaginal dilator therapy in women with vaginal agenesis (Mayer-Rokitansky-Kuster-Hauser syndrome). DESIGN:Retrospective case review. SETTING:Tertiary referral university teaching hospital clinic for disorders of sexual development and differ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Bach F,Glanville JM,Balen AH

    更新日期:2011-08-01 00:00:00

  • A firstborn boy is suggestive of a strong prognostic factor in secondary recurrent miscarriage: a confirmatory study.

    abstract:OBJECTIVE:To test our previously generated hypothesis that women with secondary recurrent miscarriages with a firstborn boy have a poorer pregnancy prognosis than those with a firstborn girl. DESIGN:A study of a retrospective and a prospective cohort. SETTING:The Danish recurrent miscarriage clinic. PATIENT(S):Two c...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Nielsen HS,Andersen AM,Kolte AM,Christiansen OB

    更新日期:2008-04-01 00:00:00

  • Misconduct in third-party assisted reproduction: a committee opinion.

    abstract::Physicians who are told or discover information that would be material to another party's participation in an assisted reproductive technology (ART) arrangement (such as lawyer's, donor's, gestational carrier's, or intended parent's) should encourage disclosure to that party. In some instances, it is ethically and leg...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,评审


    authors: Ethics Committee of the American Society for Reproductive Medicine.

    更新日期:2014-01-01 00:00:00

  • Genetic evaluation of oocyte donors: recipient couple preferences and outcome of testing.

    abstract:OBJECTIVE:To report preferences of recipient couples for genetic testing of their oocyte donors. DESIGN:Observational report of results from a genetic testing-options form implemented as part of routine care. SETTING:Private practice. PATIENT(S):Recipients and oocyte donors. INTERVENTION(S):Recipient couples comple...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Baker VL,Rone HM,Adamson GD

    更新日期:2008-12-01 00:00:00

  • Clomiphene citrate in the management of infertility associated with shortened luteal phases.

    abstract::Repetitively short luteal phases were found in eight infertile women. The short luteal phase was defined as 10 days or less from the presumed time of ovulation (as assessed by basal body temperature recording) to the onset of menses. Clomiphene citrate (Clomid) therapy resulted in pregnancy in two patients and lengthe...

    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章


    authors: Quagliarello J,Weiss G

    更新日期:1979-04-01 00:00:00

  • Relevance of assessing the uterine microbiota in infertility.

    abstract::Technical advances in massive parallel sequencing have allowed the characterization of the whole reproductive tract microbiome in all the compartments beyond the vagina. The microbiota in the uterine cavity seem to be a continuum from the microbiota in the vagina, but several works have reported significant difference...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,评审


    authors: Moreno I,Simon C

    更新日期:2018-08-01 00:00:00

  • Cost-effectiveness analysis of preimplantation genetic screening and in vitro fertilization versus expectant management in patients with unexplained recurrent pregnancy loss.

    abstract:OBJECTIVE:To determine whether in vitro fertilization with preimplantation genetic screening (IVF/PGS) is cost effective compared with expectant management in achieving live birth for patients with unexplained recurrent pregnancy loss (RPL). DESIGN:Decision analytic model comparing costs and clinical outcomes. SETTIN...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Murugappan G,Ohno MS,Lathi RB

    更新日期:2015-05-01 00:00:00

  • Placement of a Malecot catheter to enable embryo transfer after radical trachelectomy.

    abstract:OBJECTIVE:To describe the use of a Malecot catheter as a stent after radical trachelectomy (RT). DESIGN:Case report. SETTING:Assisted conception unit at a teaching hospital in the United Kingdom. PATIENT(S):A 36-year-old woman undergoing IVF after her cervix had been excised for cervical carcinoma. Previous attempts...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Aust TR,Herod JJ,Gazvani R

    更新日期:2005-06-01 00:00:00

  • Immunocytochemistry of the estrogen receptor in spontaneous endometriosis in rhesus macaques.

    abstract::Immunocytochemical, biochemical, and histologic analysis of endometriotic lesions and endometria from rhesus macaques with endometriosis revealed several distinctions between ectopic and eutopic endometrium. In lesions, unlike endometrium, neither the mean percentages of estrogen receptor positive (ER+) cells nor the ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Sternfeld MD,West NB,Brenner RM

    更新日期:1988-02-01 00:00:00

  • Characterization of two heterozygous mutations of the oocyte activation factor phospholipase C zeta (PLCζ) from an infertile man by use of minisequencing of individual sperm and expression in somatic cells.

    abstract:OBJECTIVE:To examine the underlying factors leading to infertility in a male patient from whom phospholipase C zeta H398P (PLCζ(H398P), histidine > proline) and PLCζ(H233L) (histidine > leucine) mutations were previously identified. DESIGN:Laboratory-based study. SETTING:University laboratory. PATIENT(S):An infertil...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Kashir J,Konstantinidis M,Jones C,Heindryckx B,De Sutter P,Parrington J,Wells D,Coward K

    更新日期:2012-08-01 00:00:00

  • Comparison of the action of nonoxynol-9 and chlorhexidine on sperm.

    abstract::The effect on sperm motility of nonoxynol-9 chlorhexidine diacetate was compared in semen and cervical mucus. Both compounds had similar spermicidal potency in semen, abolishing sperm motility within 3 minutes at 0.5 mg/ml. When these compounds were allowed to diffuse into mucus, the subsequent survival of sperm in th...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Sharman D,Chantler E,Dukes M,Hutchinson FG,Elstein M

    更新日期:1986-02-01 00:00:00

  • Evaluation of sperm head shape at high magnification revealed correlation of sperm DNA fragmentation with aberrant head ellipticity and angularity.

    abstract:OBJECTIVE:To test for an association between DNA fragmentation and head shape at high magnification in fresh motile spermatozoa. DESIGN:Observational study. SETTING:Academic tertiary care center. PATIENT(S):A total of 60 men in our assisted reproductive program. INTERVENTION(S):Quantifying sperm head shape using el...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Utsuno H,Oka K,Yamamoto A,Shiozawa T

    更新日期:2013-05-01 00:00:00

  • No increase in arteriolosclerotic retinopathy or activity in tests for circulating immune complexes 5 years after vasectomy.

    abstract::On the basis of studies in monkeys, the hypothesis has been proposed that vasectomy induces the formation of circulating immune complexes (CICs), which--via activation of the complement system--may result in immune injury of the endothelium and thereby exacerbate atherosclerosis; the same mechanism has been suggested ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Linnet L,Møller NP,Bernth-Petersen P,Ehlers N,Brandslund I,Svehag SE

    更新日期:1982-06-01 00:00:00

  • Involvement of FKHR (FOXO1) transcription factor in human uterus leiomyoma growth.

    abstract:OBJECTIVE:To study the expression of FOXO1 and pSer256-FOXO1 parallel to Akt and pSer473-Akt in leiomyoma compared with adjacent myometrium from human uteri. DESIGN:Prospective study. SETTING:University departments. PATIENT(S):Thirty-eight cyclic and 20 menopausal women who underwent hysterectomy for benign indicati...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Kovács KA,Lengyel F,Wilhelm F,Vértes Z,Sumegi B,Vértes M

    更新日期:2010-09-01 00:00:00

  • The likelihood of finding mature sperm cells in men with AZFb or AZFb-c deletions: six new cases and a review of the literature (1994-2010).

    abstract:OBJECTIVE:To reassess the predictive value of detecting sperm cells in men with AZFb or AZFb-c deletions. DESIGN:Retrospective analysis of previously reported men with AZFb or AZFb-c deletions and the addition of six new cases. SETTING:Fertility institution. PATIENT(S):Men with both sequence tagged site marker ident...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,评审


    authors: Kleiman SE,Yogev L,Lehavi O,Hauser R,Botchan A,Paz G,Yavetz H,Gamzu R

    更新日期:2011-05-01 00:00:00

  • Stimulation of spermatogenesis with recombinant human follicle-stimulating hormone (follitropin alfa; GONAL-f): long-term treatment in azoospermic men with hypogonadotropic hypogonadism.

    abstract:OBJECTIVE:To demonstrate the efficacy and safety of follitropin alfa administered with hCG on spermatogenesis in adult male hypogonadotropic hypogonadism (HH) patients. DESIGN:Phase III, multicenter, open-label, noncomparative. SETTING:Seven US medical centers. PATIENT(S):A total of 36 adult males with severe HH. I...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,多中心研究


    authors: Matsumoto AM,Snyder PJ,Bhasin S,Martin K,Weber T,Winters S,Spratt D,Brentzel J,O'Dea L

    更新日期:2009-09-01 00:00:00

  • Y-chromosome microdeletion and phenotype in cytogenetically normal men with idiopathic azoospermia.

    abstract:OBJECTIVE:To determine the prevalence of microdeletions of the long arm of chromosome Y within the AZFa, AZFb, and AZFc subregions in patients with idiopathic azoospermia, and then correlate the microdeletions with clinical phenotypes to determine the most important subregion for screening. DESIGN:Controlled clinical ...

    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章


    authors: Fujisawa M,Shirakawa T,Kanzaki M,Okada H,Arakawa S,Kamidono S

    更新日期:2001-09-01 00:00:00

  • Does prolonged pituitary down-regulation with gonadotropin-releasing hormone agonist improve the live-birth rate in in vitro fertilization treatment?

    abstract:OBJECTIVE:To evaluate the effects of a prolonged duration of gonadotropin-releasing hormone agonist (GnRH-a) in pituitary down-regulation for controlled ovarian hyperstimulation (COH) on the live-birth rate in nonendometriotic women undergoing in vitro fertilization and embryo transfer (IVF-ET). DESIGN:Retrospective c...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Ren J,Sha A,Han D,Li P,Geng J,Ma C

    更新日期:2014-07-01 00:00:00

  • Results of repeated tuboplasties.

    abstract::The cumulative conception rate of 31 infertile women undergoing a second tuboplasty using microsurgery was compared with that 71 women undergoing a single microsurgical tuboplasty. The follow-up period ranged from ranged from 1 to 61/2 years. Five (16%) of the patients in the repeat tuboplasty group conceived; there w...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Lauritsen JG,Pagel JD,Vangsted P,Starup J

    更新日期:1982-01-01 00:00:00

  • In vitro fertilization outcomes after intracytoplasmic sperm injection with fresh or frozen-thawed testicular spermatozoa.

    abstract:OBJECTIVE:To compare the outcomes of intracytoplasmic sperm injection (ICSI) and in vitro fertilization (IVF) with fresh and cryopreserved testicular spermatozoa in patients with obstructive and nonobstructive azoospermia. DESIGN:Retrospective analysis of consecutive ICSI cycles. SETTING:Large urban reproductive medi...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Habermann H,Seo R,Cieslak J,Niederberger C,Prins GS,Ross L

    更新日期:2000-05-01 00:00:00

  • Use of a gonadotropin-releasing hormone agonist during ovarian stimulation leads to significant concentrations of peptide in follicular fluids.

    abstract::The penetration of a gonadotropin-releasing hormone agonist (GnRH-a), Buserelin (Hoechst AG, Frankfurt, West Germany), into human follicular fluids (FF) was studied by means of a radioimmunoassay (RIA) and a bioassay. Acute nasal administration of a therapeutic dose of Buserelin (300 and 600 micrograms) before the ovu...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Loumaye E,Coen G,Pampfer S,Vankrieken L,Thomas K

    更新日期:1989-08-01 00:00:00

  • Leptin and reproduction: a review.

    abstract:OBJECTIVE:To review recent advances in understanding the role of leptin in the physiology and pathophysiology of reproduction, with a focus on relevant clinical situations. DESIGN:A MEDLINE computer search was performed to identify relevant articles. RESULT(S):Leptin, an adipocyte hormone important in regulating ener...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,评审


    authors: Moschos S,Chan JL,Mantzoros CS

    更新日期:2002-03-01 00:00:00

  • Videolaseroscopy for the treatment of endometriosis associated with infertility.

    abstract::Recent advances in laparoscopic surgery have enabled the gynecologic surgeon to treat an increased number of diseases of the reproductive organs by using the laser through the laparoscope. This article reviews the results of 243 patients with infertility associated with endometriosis ranging in severity from mild to e...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Nezhat C,Crowgey S,Nezhat F

    更新日期:1989-02-01 00:00:00

  • Neural tube defects after infertility treatment: a review.

    abstract:OBJECTIVE:To investigate whether an association exists between ovulation induction and neural tube defects (NTDs). MATERIALS AND METHODS:Risk estimations in the medical literature were identified through Medline, and validity and power were assessed. Large in vitro fertilization-embryo transfer (IVF-ET) registries rep...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,评审


    authors: Van Loon K,Besseghir K,Eshkol A

    更新日期:1992-11-01 00:00:00

  • Uterine polyps, adenomyosis, leiomyomas, and endometrial receptivity.

    abstract::Endometrial polyps, adenomyosis, and leiomyomas are commonly encountered abnormalities frequently found in both fertile women and those with infertility. The clinician is frequently challenged to determine which of these entities, when found, is likely to impair fertility, and which are "innocent bystanders" unrelated...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,评审


    authors: Munro MG

    更新日期:2019-04-01 00:00:00

  • Interruption of pregnancy by prostaglandin 15-methyl F2alpha.

    abstract::The current study was formulated to investigate the abortifacient activity of prostaglandin 15-methyl F2alpha (15-methyl PGF2alpha) administered intramuscularly to 80 healthy women with gestations between 8 and 22 weeks. Goals were the establishment of an effective dosage schedule and assessment of the incidence and s...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Bolognese RJ,Corson SL

    更新日期:1975-07-01 00:00:00

  • Serum pattern of circulating free leptin, bound leptin, and soluble leptin receptor in the physiological menstrual cycle.

    abstract:OBJECTIVE:To investigate the serum pattern of free leptin, bound leptin, and soluble leptin receptor throughout the physiological menstrual cycle. DESIGN:Prospective observational study. SETTING:Tertiary care center for gynecological endocrinology and reproductive medicine and a university research laboratory. PATIE...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Geisthövel F,Jochmann N,Widjaja A,Horn R,Brabant G

    更新日期:2004-02-01 00:00:00