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Insights from gene arrays on the development and growth regulation of uterine leiomyomata.

Abstract：

OBJECTIVE:To use microarray analysis as an unbiased approach to identify genes involved in the induction and growth of uterine leiomyomata. DESIGN:Screen by arrays for up to 12,000 genes in leiomyoma (L) and control myometrium (M) from nine patients. SETTING:University research laboratories. PATIENT(S):Nine patients in the follicular and luteal phases of the menstrual cycle. INTERVENTION(S):mRNA from L and M was converted to biotin-labeled cRNA and hybridized to cDNA oligonucleotide sequences on the arrays. MAIN OUTCOME MEASURE(S):Greater than two-fold change in gene expression between leiomyoma and matched myometrium. RESULT(S):Prominent among the 67 genes overexpressed in L relative to M were dlk or Pref-1, doublecortin, JM27, ionotropic glutamate receptor subunit 2, apolipoprotein E3, IGF2, semaphorin F, myelin proteolipid protein, MEST, frizzled, CRABP II, stromelysin-3, and TGFbeta3. The genes dlk, IGF2, and MEST are paternally expressed imprinted genes, and the others are involved in tissue differentiation and growth. Prominent among the 78 genes down-regulated in L relative to M were alcohol dehydrogenases 1alpha-gamma, tryptase, dermatopontin, thrombospondin, coxsackievirus receptor, nur77, and c-kit. CONCLUSION(S):Arrays offer large-scale screening of mRNA expression, which will help us differentiate between the genes and metabolic pathways necessary for leiomyoma growth and those regulating myometrial contractions.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Tsibris JC,Segars J,Coppola D,Mane S,Wilbanks GD,O'Brien WF,Spellacy WN

doi

10.1016/s0015-0282(02)03191-6

keywords:

subject

Has Abstract

pub_date

2002-07-01 00:00:00

pages

114-21

issue

1

eissn

0015-0282

issn

1556-5653

pii

S0015028202031916

journal_volume

78

pub_type

杂志文章

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