The role of internal spermatic vein plasma catecholamine determinations in subfertile men with varicoceles.

Abstract:

:Catecholamine concentrations were determined in left spermatic vein blood of 18 patients with varicocele. These values were compared with concentrations of catecholamines in the right femoral vein. Of 18 patients studied, 6 had moderate to marked elevations of spermatic vein catecholamine concentrations. Norepinephrine was the fractioned component that was elevated. In an average 1-year follow-up the group with elevated catecholamine levels had a much better semen improvement percentage and pregnancy rate than the other group. Chronic exposure of testicular vasculature to norepinephrine may account for the spermatogenic dysfunction encountered in varicocele patients. Once this exposure is interrupted, there may be reversibility of function and the fertility prognosis may improve. The presence of other adrenal or renal metabolites detrimental to spermatogenesis must be considered.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Cohen MS,Plaine L,Brown JS

doi

10.1016/s0015-0282(16)41541-4

subject

Has Abstract

pub_date

1975-12-01 00:00:00

pages

1243-9

issue

12

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(16)41541-4

journal_volume

26

pub_type

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