Abstract：
OBJECTIVE:To review our experience with low-dose IM methotrexate for the medical management of ectopic pregnancy (EP). DESIGN:Retrospective chart review. SETTING:Magee-Womens Hospital, Pittsburgh, Pennsylvania. PATIENT(S):The first 50 women treated by the resident service in whom EP was diagnosed and treated with methotrexate. INTERVENTION(S):Intramuscular methotrexate, 50 mg/m2. Serum beta-hCG was evaluated 4 and 7 days after treatment and then weekly thereafter. The dose was repeated if the beta-hCG level did not drop > or = 15% between days 4 and 7 or if a plateau or rise was noted during weekly follow-up evaluation. Surgery was performed if significant abdominal pain occurred in the presence of hemodynamic instability or signs of peritoneal irritation on physical examination. MAIN OUTCOME MEASURE(S):Resolution of the EP without surgical intervention. RESULT(S):Two patients were lost to follow-up and one was treated without a certain diagnosis of EP. Forty-three of the remaining 47 women (91.5%; 95% confidence interval, 83.5%, 99.5%) were treated successfully with methotrexate. Of these, 36 women were treated with a single dose, and 7 required a second dose. Four women were treated surgically after medical management failed. The time from initiation of treatment to cure in women who were treated successfully was 25 +/- 15 days (mean +/- SD). Thirteen patients (27.7%) made additional visits to the emergency department because of increased abdominal pain. CONCLUSION(S):As medical therapy for EP becomes common practice, familiarity with its side effects may lead to greater success rates. The decision to abandon medical treatment and proceed with surgery should be based on defined guidelines, such as the development of peritoneal signs, decreasing hemoglobin levels, or hemodynamic instability.
journal_name
Fertil Steriljournal_title
Fertility and sterilityauthors
Thoen LD,Creinin MDdoi
10.1016/s0015-0282(97)00284-7subject
Has Abstractpub_date
1997-10-01 00:00:00pages
727-30issue
4eissn
0015-0282issn
1556-5653pii
S0015-0282(97)00284-7journal_volume
68pub_type
杂志文章abstract：:A surrogate end point (e.g., a laboratory test or image) serves as a proxy for a clinical end point of importance (e.g., fracture, thrombosis, or death). Adoption and use of surrogate end points lacking validation, especially in cardiovascular medicine, have caused thousands of patients' deaths, a serious violation of...
journal_title：Fertility and sterility
pub_type： 社论,评审
doi：10.1016/j.fertnstert.2009.12.054
更新日期：2010-04-01 00:00:00
abstract：:This retrospective cohort study compared blastocyst transfers in 136 fresh oocyte donor cycles and 69 autologous cycles using blastocysts derived from culture of thawed bipronuclear oocytes, all with oocytes derived from patients or donors less than 35 years old. The autologous cycles and oocyte donor cycles had simil...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2009.07.966
更新日期：2010-01-01 00:00:00
abstract：OBJECTIVE:To establish the relative frequency of aneuploidy in sperm from normal and abnormal subjects using dual color fluorescence in situ hybridization and probes for six different chromosomes. DESIGN:Semen from 33 normal males and a patient with a translocation was studied using dual color fluorescence in situ hyb...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)56896-4
更新日期：1994-08-01 00:00:00
abstract：OBJECTIVE:To determine whether magnetic resonance imaging (MRI) and serum levels of CA-125 can be used to evaluate patients with endometriomas before initiating medical treatment. DESIGN:Comparative study before and after medical treatment. SETTING:Shimane Medical University Hospital, Izumo, Japan. PATIENTS:Eleven c...
journal_title：Fertility and sterility
pub_type： 临床试验,杂志文章
doi：10.1016/s0015-0282(16)58087-x
更新日期：1996-02-01 00:00:00
abstract：OBJECTIVE:To examine the relationship of ovulation-inducing drugs and ovarian cancer. DESIGN:Retrospective cohort study, with additional follow-up since initial report. SETTING:Five large reproductive endocrinology practices. PATIENT(S):In a retrospective cohort of 9,825 women evaluated for infertility at five clini...
journal_title：Fertility and sterility
pub_type： 杂志文章,多中心研究
doi：10.1016/j.fertnstert.2013.08.008
更新日期：2013-12-01 00:00:00
abstract：:Serum anti-Müllerian hormone concentrations vary significantly over time and this should be taken into account when tailoring treatment protocols for patients undergoing controlled ovarian hyperstimulation (COH). Compared with FSH, serum anti-Müllerian hormone may have greater discriminatory power because of its modes...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2010.10.001
更新日期：2011-03-01 00:00:00
abstract：:A case is described in which, after a tubal sterilization procedure and subsequent unilateral tubal anastomosis, an ectopic gestation occurred in the contralateral, unrepaired, distal tubal segment. On the basis of this case and related evidence, the authors suggest that in cases in which only a unilateral tubal anast...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)59068-2
更新日期：1987-03-01 00:00:00
abstract：OBJECTIVE:To determine the variability in the recognition of normal sperm and various sperm defects using the strict criteria recommended by the World Health Organization (5th edition, 2010). DESIGN:Sperm morphologic assessment by three experienced evaluators. SETTING:Image processing laboratory and reproduction rese...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2013.12.047
更新日期：2014-04-01 00:00:00
abstract：:We aimed to investigate the effects of LH and FSH on the gene expression of the platelet-derived growth factor (PDGF) gene family in human granulosa-luteal cells. We found that LH significantly increased PDGF-D messenger RNA (mRNA) expression but suppressed PDGF-B and PDGF-C mRNA in human granulosa-luteal cells, and F...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2009.05.064
更新日期：2009-12-01 00:00:00
abstract：OBJECTIVE:To perform a systematic review and meta-analysis of studies that compared the prevalence of anxiety symptoms in women with polycystic ovary syndrome (PCOS) and control women. DESIGN:Meta-analysis and systematic review. SETTING:University practice. PATIENT(S):Cross-sectional studies comparing PCOS subjects ...
journal_title：Fertility and sterility
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.fertnstert.2011.10.022
更新日期：2012-01-01 00:00:00
abstract：OBJECTIVE:To report a rare case of somatic mosaicism with a germline component of campomelic dysplasia in a woman undergoing in vitro fertilization with preimplantation genetic diagnosis (IVF-PGD). DESIGN:Case report. SETTING:Clinic. PATIENT(S):A 28-year old G2P0110 and her 34-year old husband had two previous pregn...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2018.05.002
更新日期：2018-09-01 00:00:00
abstract：:We found, by reverse transcription--real time--polymerase chain reaction, that the expression of aromatase (CYP19) in ovarian, peritoneal endometriosis, and deep endometriotic nodules is significantly different, which strengthens the theory of three distinct clinical entities. Compared with peritoneal endometriosis, o...
journal_title：Fertility and sterility
pub_type： 临床试验,杂志文章
doi：10.1016/j.fertnstert.2005.10.041
更新日期：2006-05-01 00:00:00
abstract：OBJECTIVE:To evaluate the association between follicular and serum nitric oxide (NO) levels and embryo development and outcome in IVF. DESIGN:Prospective, case-control study. SETTING:University hospital, tertiary medical center. PATIENT(S):Eighteen patients with tubal or peritoneal factor infertility and 18 female p...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2004.02.097
更新日期：2004-07-01 00:00:00
abstract：:The comprehensive "one-stop shop" ultrasound evaluation of an infertile woman, performed around cycle days 5 to 9, will reveal abundant information about the anatomy and morphology of the pelvic organs and thereby avoid costly radiation and iodinated contrast exposure. We propose a two-dimensional and three-dimensiona...
journal_title：Fertility and sterility
pub_type： 杂志文章,评审
doi：10.1016/j.fertnstert.2016.03.026
更新日期：2016-06-01 00:00:00
abstract：OBJECTIVE:To investigate the parameters of mosaicism and the biological mechanisms leading to healthy pregnancies from mosaic embryo transfers. DESIGN:Prospective study. SETTING:IVF center and associated research laboratory. PATIENT(S):Fifty-nine patients. INTERVENTION(S):Embryos underwent blastocyst-stage preimpla...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2018.10.019
更新日期：2019-02-01 00:00:00
abstract：OBJECTIVE:To evaluate the influence of socioeconomic factors on the outcomes of infertility, including pregnancy, adoption, resolution, and loss to follow-up. DESIGN:Prospective observational study. SETTING:Infertility clinics in 11 teaching hospitals. PATIENTS:Newly registered couples with infertility of > 1 year. ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：
更新日期：1993-09-01 00:00:00
abstract：:Of 5,341 infertile couples seen over an 8-year period, 76 (1.4%) had primary vaginismus, of whom 63 were treated with the use of a simplified sensate focus technique. There was complete symptomatic resolution of vaginismus in 60 women, and pregnancy was achieved in 33. ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2010.03.071
更新日期：2010-11-01 00:00:00
abstract：OBJECTIVE:To study the association of perinatal outcome and IVF transfer type in a group of infertility patients with standardized treatment and similar prognosis. DESIGN:Retrospective cohort study. SETTING:University-based infertility center, January 1998 to June 2006. PATIENT(S):Two hundred eighteen IVF pregnancie...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2010.05.049
更新日期：2011-02-01 00:00:00
abstract：OBJECTIVE:To investigate the effect of the anti-P Org 31710 on human blastocyst attachment to cultured endometrial epithelial cells. DESIGN:Experimental in vitro study. SETTING:University hospital. PATIENT(S):Eleven fertile endometrial donors. INTERVENTION(S):Timed endometrial biopsy for cell cultures. MAIN OUTCOM...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2004.08.040
更新日期：2005-04-01 00:00:00
abstract：:Transvaginal follicular aspiration (TVA) with ultrasonically guided needles allows the transfer of in vitro generated embryos to the fallopian tubes (TET), performing only one surgical procedure in the process. Up to now, this approach has been used to treat 16 couples with infertility due to severe male factor. Folli...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)60136-x
更新日期：1988-09-01 00:00:00
abstract：OBJECTIVE:To present a report on assisted reproductive technologies (ART) cycles performed in 2005 in Canada. This is the fifth annual report from the Canadian ART Register (CARTR). DESIGN:Prospective cohort study. SETTING:Twenty-five of 25 ART centers in Canada. PARTICIPANT(S):Couples undergoing ART treatment in Ca...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2008.02.125
更新日期：2009-05-01 00:00:00
abstract：:In this prospective case-control study, we determined the role of surface-enhanced laser desorption and ionization time-of-flight mass spectrometry in the detection of histologically proven endometriosis. In the plasma of the group with endometriosis, there were 20 different protein peaks, and the classifier showed a ...
journal_title：Fertility and sterility
pub_type： 信件
doi：10.1016/j.fertnstert.2006.08.095
更新日期：2007-04-01 00:00:00
abstract：OBJECTIVE:To determine whether men with azoospermia are at an elevated risk of developing cancer in the years following an infertility evaluation. DESIGN:Cohort study. SETTING:United States andrology clinic. PATIENT(S):A total of 2,238 men with complete records were evaluated for infertility at a single andrology cl...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2013.05.022
更新日期：2013-09-01 00:00:00
abstract：:It is clear that women with primary ovarian insufficiency are asking the health care community to alter the current standard, which requires the patient to seek a different specialist for each of her health care needs, and instead work as a team of caregivers that embraces each patient as a woman with complex and indi...
journal_title：Fertility and sterility
pub_type： 评论,杂志文章
doi：10.1016/j.fertnstert.2011.03.006
更新日期：2011-05-01 00:00:00
abstract：OBJECTIVE:To determine prospectively whether the use of low-dose estrogen oral contraceptives (OC) is associated with changes in weight, body composition, or fat distribution. DESIGN:Anthropometric measurements were performed in 49 healthy young (16 to 21 years old) women before commencement of OC use (30 micrograms e...
journal_title：Fertility and sterility
pub_type： 临床试验,杂志文章
doi：10.1016/s0015-0282(16)57419-6
更新日期：1995-03-01 00:00:00
abstract：OBJECTIVE:To review the association between autoimmunity and reproductive failure. DESIGN:A MEDLINE search done from 1965 to 1996. More than 300 original and review articles were evaluated, from which the most relevant were selected. RESULT(S):Autoimmune processes now are accepted widely as one of the possible mechan...
journal_title：Fertility and sterility
pub_type： 杂志文章,评审
doi：10.1016/s0015-0282(97)81351-9
更新日期：1997-04-01 00:00:00
abstract：OBJECTIVE:To demonstrate three approaches to uterine artery occlusion at time of myomectomy as a blood-sparing intraoperative technique. DESIGN:A step-by-step explanation of the procedure with surgical video footage. SETTING:Academic medical center. PATIENT(S):Patients undergoing laparoscopic myomectomy, for whom a ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2019.01.019
更新日期：2019-05-01 00:00:00
abstract：:A randomized prospective study was performed to compare the effects of a midfundal versus a deep fundal transfer technique on subsequent intrauterine and ectopic PRs after IVF. The clinical intra-uterine PR after the deep fundal transfer was 12.4% per cycle with a 1.5% ectopic PR (which represented 12.2% of the pregna...
journal_title：Fertility and sterility
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1993-11-01 00:00:00
abstract：OBJECTIVE:To evaluate the efficacy of elagolix, an oral GnRH antagonist, for the reduction of fatigue in women with moderate or severe endometriosis-associated pain. DESIGN:Randomized, double-blind, multicenter, placebo-controlled phase III trial. SETTING:Clinics. PATIENT(S):A total of 860 women treated with elagoli...
journal_title：Fertility and sterility
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.fertnstert.2019.02.031
更新日期：2019-08-01 00:00:00
abstract：OBJECTIVE:To determine whether foot reflexology, a complementary therapy, has an effect greater than sham reflexology on induction of ovulation. DESIGN:Sham-controlled randomized trial with patients and statistician blinded. SETTING:Infertility clinic in Plymouth, United Kingdom. PATIENT(S):Forty-eight women attendi...
journal_title：Fertility and sterility
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.fertnstert.2008.04.016
更新日期：2009-06-01 00:00:00
