Abstract:
OBJECTIVE:To investigate the parameters of mosaicism and the biological mechanisms leading to healthy pregnancies from mosaic embryo transfers. DESIGN:Prospective study. SETTING:IVF center and associated research laboratory. PATIENT(S):Fifty-nine patients. INTERVENTION(S):Embryos underwent blastocyst-stage preimplantation genetic testing for aneuploidy by next-generation sequencing. Trophectoderm biopsies containing 20%-80% abnormal cells were deemed mosaic, and corresponding blastocysts were transferred. Mosaic embryos donated to research were examined for karyotype concordance in multiple biopsies and assessed for cell proliferation and death by immunofluorescence and computational quantitation. MAIN OUTCOME MEASURE(S):Chemical start of pregnancy, implantation, fetal heartbeat, and birth. RESULT(S):Globally, mosaic embryos showed inferior clinical outcomes compared with euploid embryos. Aneuploid cell percentage in trophectoderm biopsies did not correlate with outcomes, but type of mosaicism did, as embryos with single mosaic segmental aneuploidies fared better than all other types. Mosaic blastocysts generated from oocytes retrieved at young maternal ages (≤34 years) showed better outcomes than those retrieved at older maternal ages. Mosaic embryos displayed low rates of karyotype concordance between multiple biopsies and showed significant elevation of cell proliferation and death compared with euploid embryos. CONCLUSION(S):After euploid embryos, mosaic embryos can be considered for transfer, prioritizing those of the single segmental mosaic type. If a patient has mosaic embryos available that were generated at different ages, preference should be given to those made at younger ages. Intrablastocyst karyotype discordance and differential cell proliferation and death might be reasons that embryos classified as mosaic can result in healthy pregnancies and babies.
journal_name
Fertil Steriljournal_title
Fertility and sterilityauthors
Victor AR,Tyndall JC,Brake AJ,Lepkowsky LT,Murphy AE,Griffin DK,McCoy RC,Barnes FL,Zouves CG,Viotti Mdoi
10.1016/j.fertnstert.2018.10.019subject
Has Abstractpub_date
2019-02-01 00:00:00pages
280-293issue
2eissn
0015-0282issn
1556-5653pii
S0015-0282(18)32141-1journal_volume
111pub_type
杂志文章abstract::Postoperative adhesions are a natural consequence of surgical tissue trauma and healing and may result in infertility, pain, and bowel obstruction. Adherence to microsurgical principles, minimally invasive surgery, and use of some peritoneal instillates may help to decrease postoperative adhesions. Some surgical barri...
journal_title:Fertility and sterility
pub_type: 杂志文章,评审
doi:10.1016/j.fertnstert.2007.04.066
更新日期:2007-07-01 00:00:00
abstract::Fresh semen specimens from fertile donors were subjected to one-step and two-step washings in six various commonly used artificial media. It was found that washing procedures per se, in most cases, had an immediate and extended harmful effect on sperm motility which was much more prominent after the second washing. Ho...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)45441-5
更新日期:1981-04-01 00:00:00
abstract:OBJECTIVE:To examine the impact of a recent surgery on development of endometriosis-related adhesions in a chimeric model and to determine the therapeutic efficacy of pioglitazone (PIO). DESIGN:Human endometrial biopsies were maintained in E(2) with or without PIO for 24 h before intraperitoneal injection into immunoc...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2010.09.017
更新日期:2011-03-15 00:00:00
abstract::Surveillance is a triennial worldwide compendium of national rules and regulations for assisted reproductive technology. It was last published in 2010. ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2014.03.045
更新日期:2014-06-01 00:00:00
abstract::One hundred and two women with insulin-resistant polycystic ovary syndrome were randomized to treatment with a vitamin B preparation, metformin, or both, in conjunction with standard infertility treatment. Plasma homocysteine levels were significantly reduced by both B vitamins and metformin, but to a greater degree b...
journal_title:Fertility and sterility
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.fertnstert.2006.11.071
更新日期:2007-07-01 00:00:00
abstract:OBJECTIVE:To investigate whether antitrophoblast antibodies are associated with unexplained recurrent miscarriages, we used choriocarcinoma cells JEG-3, since these cells are negative for class I and II antigens, but they do express HLA-G, resembling an antigen expression of endovascular and interstitial trophoblasts. ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2011.11.014
更新日期:2012-02-01 00:00:00
abstract:OBJECTIVE:To prospectively assess whether metformin diet safely provides primary and secondary prevention of gestational diabetes (GD). DESIGN:Assess development of GD on metformin diet. SETTING:Outpatient clinical research center. PATIENT(S):One hundred forty-two nondiabetic women with polycystic ovary syndrome (PC...
journal_title:Fertility and sterility
pub_type: 临床试验,杂志文章
doi:10.1016/j.fertnstert.2007.03.036
更新日期:2008-03-01 00:00:00
abstract:OBJECTIVE:To evaluate the association between genetic variants in Ser-Arg (SR) protein-coding genes and the susceptibility of nonobstructive azoospermia (NOA) in Chinese men. DESIGN:Case-control study. SETTING:State Key Laboratory of Reproductive Medicine in Nanjing Medical University conducted the genotyping and exa...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2014.02.033
更新日期:2014-06-01 00:00:00
abstract:OBJECTIVE:Evaluation of the Creatsas modification of Williams vaginoplasty for the creation of neovagina in patients with Mayer-Rokitansky-Küster-Hauser syndrome (MRKH syndrome). DESIGN:Record of perioperative and postoperative results and complications. Follow-up evaluations of patients yearly after the operation. S...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(01)02836-9
更新日期:2001-11-01 00:00:00
abstract:OBJECTIVE:To examine the literature systematically in order to identify prospective comparative trials answering the following question: Is vitrification of human embryos associated with a higher postthawing survival rate as compared with slow freezing? DESIGN:Systematic review and meta-analysis. SETTING:University-b...
journal_title:Fertility and sterility
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.fertnstert.2007.06.010
更新日期:2008-07-01 00:00:00
abstract:OBJECTIVE:To determine if gonadotropin suppression improves ovarian follicle function or ovulation rates in patients with karyotypically normal spontaneous premature ovarian failure. DESIGN:Prospective, double-blind, placebo-controlled, crossover trial. SETTING:Tertiary care research institution. INTERVENTIONS:Two i...
journal_title:Fertility and sterility
pub_type: 临床试验,杂志文章
doi:10.1016/s0015-0282(16)54775-x
更新日期:1992-01-01 00:00:00
abstract:OBJECTIVES:To test, using the immunobead binding technique, for the presence of antisperm antibodies on epididymal sperm, in epididymal fluid, and in serum of men with congenital absence of the vas deferens. To evaluate the in vitro fertilization (IVF) capacity of human epididymal sperm in the presence of antisperm ant...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)55451-x
更新日期:1992-11-01 00:00:00
abstract:OBJECTIVE:To examine the effectiveness of subinguinal microsurgical varicocelectomy in the treatment of persistent or recurrent varicocele. DESIGN:Retrospective chart review. SETTING:Urban, tertiary care, academic teaching hospital. PATIENT(S):Fifty-four men who presented for treatment of persistent or recurrent var...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2004.03.028
更新日期:2004-09-01 00:00:00
abstract:OBJECTIVE:To determine the prevalence and type of Y chromosome microdeletions in 136 consecutively seen intracytoplasmic sperm injection (ICSI) candidates and in 50 consecutively seen azoospermic men attending an infertility clinic. DESIGN:Controlled clinical study. SETTING:Genetics laboratory and infertility clinic ...
journal_title:Fertility and sterility
pub_type: 临床试验,杂志文章
doi:10.1016/s0015-0282(98)00195-2
更新日期:1998-09-01 00:00:00
abstract:OBJECTIVE:To evaluate the titanium Kirsch-Zhu microclip microsurgical reanastomoses of the fallopian tubes. DESIGN:Compare the reanastomoses of the rat uterine horn between Kirsch-Zhu clips (Cushman Engineering, Albuquerque, NM) (group A) and conventional suture microsurgical techniques (group B). SETTING:Microsurger...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)56955-6
更新日期:1994-09-01 00:00:00
abstract:OBJECTIVE:To describe three cases of azoospermia in patients with oligospermia after clomiphene citrate (CC) intake. DESIGN:Case report. SETTING(S):Academic medical center. PATIENT(S):Three patients with oligospermia. INTERVENTION(S):Three oligospermic men used CC, resulting in azoospermia. MAIN OUTCOME MEASURE(S)...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2008.03.036
更新日期:2008-11-01 00:00:00
abstract:OBJECTIVE:To evaluate the efficacy of transvaginal intratubal methotrexate (MTX) treatment of tubal ectopic pregnancy (EP). SETTING:Outpatient setting in University Hospital. PATIENTS:Forty women with early EP and rising serum beta-human chorionic gonadotropin (beta-hCG) levels. INTERVENTION:Transvaginal intratubal ...
journal_title:Fertility and sterility
pub_type: 临床试验,杂志文章
doi:10.1016/s0015-0282(16)55143-7
更新日期:1992-07-01 00:00:00
abstract::Microsurgical nonvascularized transplantation of a 1-cm segment of fallopian tube was performed using the rabbit as a model. Autograft experiments showed survival of a 1-cm tubal segment for as long as 10 months postoperatively. Allografts survived equally as well, and one rabbit became pregnant. ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)45691-8
更新日期:1981-08-01 00:00:00
abstract::Most oocyte donation programs have experienced higher pregnancy rates than usually seen in regular in vitro fertilization (IVF), suggesting that the quality of either the oocytes or the endometrium is superior. To clarify this issue we analyzed the results of transfers of 136 cryopreserved embryos originating either f...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)53830-8
更新日期:1990-10-01 00:00:00
abstract:OBJECTIVE:In rodents, evidence suggests that the leptin system is mandatory for embryonic implantation. We aimed to investigate the functional relevance of the endometrial leptin receptor (OB-R) in the adhesion phase of human implantation. DESIGN:We used an in vitro model for embryonic adhesion, composed of a human en...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2006.12.028
更新日期:2007-10-01 00:00:00
abstract:OBJECTIVE:To investigate the effect of paternal body mass index (BMI) on neonatal outcomes of singletons after frozen-thawed embryo transfer (FET) cycles. DESIGN:Retrospective cohort study. SETTING:Tertiary-care academic medical center. PATIENT(S):A total of 7,908 singleton newborns were divided into four categories...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2020.02.100
更新日期:2020-06-01 00:00:00
abstract::Two hundred ten treatment cycles of follicle-stimulating hormone (FSH) or human menopausal gonadotropin (hMG) were completed in 49 patients with clomiphene citrate-resistant polycystic ovarian syndrome. The results from 68 cycles of daily intramuscular (IM) FSH and 41 cycles of IM hMG were compared. The ovulation rate...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)53511-0
更新日期:1990-05-01 00:00:00
abstract:OBJECTIVE:To introduce a technique for hysteroscopic resection of submucous myoma arising from the uterine fundus. DESIGN:Case report. SETTING:University hospital. PATIENT(S):A 43-year-old nulliparous Japanese woman. INTERVENTION(S):An original combination technique of hysteroresectoscopy using circumferential myom...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2006.03.066
更新日期:2006-11-01 00:00:00
abstract::This prospective study evaluated the efficacy of transvaginal ultrasonography combined with water-contrast in the rectum (RWC-TVS) in the diagnosis of rectal infiltration in 35 women with rectovaginal endometriosis; ultrasonographic findings were compared with surgery and histology. The sensitivity of RWC-TVS in ident...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2007.07.1336
更新日期:2008-03-01 00:00:00
abstract:OBJECTIVE:To assess the efficacy of a novel protocol-microdose GnRH agonist (GnRH-a), FSH, and GH, for the stimulation of IVF patients who were canceled previously on a standard luteal GnRH-a, FSH, GH protocol. DESIGN:Prospective evaluation using the patient's previous IVF stimulation attempt as historic controls. SE...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(97)81862-6
更新日期:1997-01-01 00:00:00
abstract:OBJECTIVE:To study the incidence rate and hazard ratios of diabetes and prediabetes between women with PCOS and healthy subjects. DESIGN:Prospective population-based study. SETTING:Not applicable. PATIENT(S):Women with PCOS (n = 178) and eumenorrheic, nonhirsute, healthy women as controls (n = 1,524), all followed f...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2017.09.004
更新日期:2017-12-01 00:00:00
abstract::Peritoneal fluid and serum were collected from 78 patients at the time of laparoscopy. Twenty-two were fertile controls (CTL), and 56 were infertility patients, who were subdivided into three main groups: endometriosis (EMS), pelvic adhesions (ADH), and ovarian dysfunction (OvDF). Based on control group data, biochemi...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)48020-9
更新日期:1984-08-01 00:00:00
abstract::The level of the "Beaumont" protein present in serum was measured by a population of 223 black and 76 Caucasian women with different exposures to oral contraceptives (OCs). No differences were found in the values in nonusers, past users, current users, or new users of OCs. The values were higher in black nonusers and ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:
更新日期:1983-10-01 00:00:00
abstract::There was no difference in the density of nerve fibers across the menstrual cycle in peritoneal endometriotic lesions. These findings may explain why patients with peritoneal endometriosis often have painful symptoms throughout the menstrual cycle. ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2011.01.150
更新日期:2011-06-30 00:00:00
abstract::To evaluate the effect of luteal estrogen supplementation on pregnancy rates in normal responder IVF patients treated with recombinant FSH and fixed multidose GnRH antagonist, patients were randomized into two groups to receive vaginal 600 mg/d micronized progesterone for luteal phase supplementation with or without t...
journal_title:Fertility and sterility
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.fertnstert.2007.08.029
更新日期:2008-06-01 00:00:00