Genetic variants in Ser-Arg protein-coding genes are associated with the risk of nonobstructive azoospermia in Chinese men.


OBJECTIVE:To evaluate the association between genetic variants in Ser-Arg (SR) protein-coding genes and the susceptibility of nonobstructive azoospermia (NOA) in Chinese men. DESIGN:Case-control study. SETTING:State Key Laboratory of Reproductive Medicine in Nanjing Medical University conducted the genotyping and examined the expression levels of genes. PATIENT(S):The study included 962 NOA patients and 1,931 control subjects. INTERVENTION(S):None. MAIN OUTCOME MEASURE(S):Genotyping of 16 single-nucleotide polymorphisms (SNPs) of eight "canonic" SR protein-coding genes were performed with the use of the Illumina Infinium Beadchip platform. Odds ratios were calculated by logistic regression analysis in the additive model. Expression levels were measured by quantitative reverse-transcription polymerase chain reaction. RESULT(S):Rs17431717 near SFRS9 and rs12046213 near SFRS4 were significantly associated with a decreased risk of NOA, whereas rs10849753 near SFRS9 and rs6103330 in SFRS6 were associated with an increased risk of NOA. Of the two SNPs in SFRS9, only rs17431717 remained significant after conditioning on another. Combined analysis of three promising SNPs (rs17431717, rs12046213, and rs6103330) showed that compared with individuals with "0-2" risk alleles, those carrying "3," "4," and "≥ 5" risk alleles had 1.22-, 1.38-, and 1.90-fold increased risk of NOA, respectively. CONCLUSION(S):Polymorphisms in SR protein-coding genes may contribute to the risk of NOA in Chinese men. The findings of this study can help us to further understand the etiology of spermatogenic impairment, and they provide more evidence for the role of splicing activity in human spermatogenesis.


Fertil Steril


Fertility and sterility


Ni B,Ma H,Lin Y,Dai J,Guo X,Xia Y,Sha J,Hu Z




Has Abstract


2014-06-01 00:00:00














  • Increased plasma visfatin concentrations in women with polycystic ovary syndrome.

    abstract:OBJECTIVE:To test the hypothesis that plasma visfatin concentrations will be higher in women with polycystic ovary syndrome (PCOS) than in women without PCOS. DESIGN:Clinical study. SETTING:University hospital. PATIENT(S):A total of 52 women were evaluated. Twenty-six had PCOS, and the remaining 26 were healthy wome...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Chan TF,Chen YL,Chen HH,Lee CH,Jong SB,Tsai EM

    更新日期:2007-08-01 00:00:00

  • Midfollicular anticardiolipin and antiphosphatidylserine antibody titers do not correlate with in vitro fertilization outcome.

    abstract:OBJECTIVE:To determine the prevalence of anticardiolipin and antiphophatidylserine antibodies in an IVF population and to correlate their presence and specific isotype with IVF cycle outcome. DESIGN:Retrospective clinical study using stored midfollicular sera for determination of antibody status. SETTING:University h...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Kowalik A,Vichnin M,Liu HC,Branch W,Berkeley AS

    更新日期:1997-08-01 00:00:00

  • Outcome after surgery for deep endometriosis infiltrating the rectum.

    abstract:OBJECTIVE:To evaluate the rate of postoperative complications between conservative surgery and segmental resection in patients with rectal endometriosis. DESIGN:Single-center retrospective study. SETTING:University hospital. PATIENT(S):A total of 232 women undergoing surgery for deep endometriosis infiltrating the r...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Bafort C,van Elst B,Neutens S,Meuleman C,Laenen A,d'Hoore A,Wolthuis A,Tomassetti C

    更新日期:2020-06-01 00:00:00

  • Reliability of narrow-band imaging (NBI) hysteroscopy: a comparative study.

    abstract:OBJECTIVE:To evaluate the usefulness of narrow-band imaging (NBI) technology for improving the diagnostic reliability of hysteroscopy. DESIGN:Prospective controlled clinical study (Canadian Task Force classification II-2). SETTING:University hospital. PATIENT(S):Three hundred ninety-five outpatient women undergoing ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Cicinelli E,Tinelli R,Colafiglio G,Pastore A,Mastrolia S,Lepera A,Clevin L

    更新日期:2010-11-01 00:00:00

  • Tuba uterina leukemia inhibitory factor concentration does not increase in tubal pregnancy: a preliminary study.

    abstract::The aim of the present study was to compare the levels of leukemia inhibitory factor (LIF) in the tubal ampullary region in normal and ectopic pregnancies and assess possible causative role of LIF in ectopic pregnancy. Although there was a tendency of increase in LIF concentrations in the ectopic pregnancy group, we w...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Kiran G,Kiran H,Ertopcu K,Kilinc M,Ekerbicer HC,Vardar MA

    更新日期:2005-02-01 00:00:00

  • Strategies for disclosure: how parents approach telling their children that they were conceived with donor gametes.

    abstract:OBJECTIVE:To describe how parents envision, plan, and enact disclosing to their children that they were conceived with donor gametes. DESIGN:In-depth ethnographic interviews. SETTING:Participants were recruited from 11 medical infertility practices and 1 sperm bank in Northern California. PATIENT(S):A total of 141 m...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Mac Dougall K,Becker G,Scheib JE,Nachtigall RD

    更新日期:2007-03-01 00:00:00

  • "Spot"-ting differences between the ectopic and eutopic endometrium of endometriosis patients.

    abstract:OBJECTIVE:To examine proteins aberrantly expressed in the ectopic endometrium compared with eutopic endometrium from the same patient. DESIGN:Experimental study. SETTING:Research institute and an obstetrics and gynecology clinic (National Institute for Research in Reproductive Health and Sanjeevani Diagnostic Center ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Chehna-Patel N,Sachdeva G,Gajbhiye R,Warty N,Khole V

    更新日期:2010-11-01 00:00:00

  • Characterization of the injection funnel during intracytoplasmic sperm injection reflects cytoplasmic maturity of the oocyte.

    abstract:OBJECTIVE:To quantify cytoplasmic maturity on the basis of intracytoplasmic sperm injection (ICSI) injection funnel manifestation and to evaluate influence factors of the latter. DESIGN:Prospective study. SETTING:Private fertility center. PATIENT(S):A total of 31 patients with good ovarian response. INTERVENTION(S)...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Krause I,Pohler U,Grosse S,Shebl O,Petek E,Chandra A,Ebner T

    更新日期:2016-10-01 00:00:00

  • Glucocorticoid receptor-mediated regulation of MMP9 gene expression in human ovarian surface epithelial cells.

    abstract:OBJECTIVE:To obtain proof-of-concept that locally produced anti-inflammatory steroids suppress ovulation-associated extracellular matrix proteases in human ovarian surface epithelial (OSE) cells. DESIGN:Primary OSE cell cultures treated with interleukin-1alpha (IL-1alpha) (500 pg/mL) as proxy for inflammation, with/wi...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Rae MT,Price D,Harlow CR,Critchley HO,Hillier SG

    更新日期:2009-08-01 00:00:00

  • Ovarian suppression induced with Buserelin or danazol in the management of endometriosis: a randomized, comparative study.

    abstract::The effectiveness of Buserelin (Hoechst-Roussel Pharmaceuticals, Inc., Somerville, NJ) (0.2 mg subcutaneously [SC] or 1.2 mg intranasally [IN] per day) and danazol (800 mg per day) in inducing ovarian suppression for the management of endometriosis was compared in a prospective randomized study. During 6 months of tre...

    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Dmowski WP,Radwanska E,Binor Z,Tummon I,Pepping P

    更新日期:1989-03-01 00:00:00

  • Importance of the biopsy date in autologous endometrial cocultures for patients with multiple implantation failures.

    abstract:OBJECTIVE:To analyze the effectiveness of autologous endometrial coculture by the cycle day of the endometrial biopsy. DESIGN:Retrospective study. SETTING:University-based IVF center. PATIENT(S):Two hundred eight patients with multiple IVF failures. INTERVENTION(S):Embryos were split and randomly allocated to growt...

    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Spandorfer SD,Barmat LI,Navarro J,Liu HC,Veeck L,Rosenwaks Z

    更新日期:2002-06-01 00:00:00

  • Risk factors for extrauterine pregnancy in women using an intrauterine device.

    abstract:OBJECTIVE:To identify the risk factors for ectopic pregnancy (EP) in women using an intrauterine device (IUD). DESIGN:Case-control study. SETTING:Auvergne region (France). PATIENT(S):Women using an IUD and suffering EP (243 cases) or having an intrauterine pregnancy (140 controls). INTERVENTION(S):None. MAIN OUTCO...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Bouyer J,Rachou E,Germain E,Fernandez H,Coste J,Pouly JL,Job-Spira N

    更新日期:2000-11-01 00:00:00

  • NR5A1 (SF-1) gene variants in a group of 26 young women with XX primary ovarian insufficiency.

    abstract:OBJECTIVE:To determine whether NR5A1 (SF-1) variants are a cause of primary ovarian insufficiency (POI) in 26 young women with similar genetic background. DESIGN:Genetic and functional mutation study. SETTING:University hospitals. PATIENT(S):Genetic analysis of the NR5A1 gene in 26 XX girls with POI. INTERVENTION(S...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Philibert P,Paris F,Lakhal B,Audran F,Gaspari L,Saâd A,Christin-Maître S,Bouchard P,Sultan C

    更新日期:2013-02-01 00:00:00

  • A placebo-controlled double-blind randomized trial of the use of combined l-carnitine and l-acetyl-carnitine treatment in men with asthenozoospermia.

    abstract:OBJECTIVE:To determine the efficacy of combined l-carnitine and l-acetyl-carnitine therapy in infertile males with oligo-astheno-teratozoospermia. DESIGN:Placebo-controlled double-blind randomized trial. SETTING:University tertiary referral center. PATIENT(S):Sixty infertile patients (aged 20-40 years) with the foll...

    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Lenzi A,Sgrò P,Salacone P,Paoli D,Gilio B,Lombardo F,Santulli M,Agarwal A,Gandini L

    更新日期:2004-06-01 00:00:00

  • Effects of fibrin sealant on single-layer uterine incision closure in the New Zealand white rabbit.

    abstract:OBJECTIVE:To determine if the addition of fibrin sealant to incision closure in a rabbit uterine horn myomectomy model affects adhesion formation or strength of incision closure. DESIGN:Prospective randomized controlled trial. SETTING:Academic research center. ANIMAL(S):New Zealand white female rabbits. INTERVENTIO...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Peacock KE,Hurst BS,Marshburn PB,Matthews ML

    更新日期:2006-04-01 00:00:00

  • Incomplete and inconsistent reporting of maternal and fetal outcomes in infertility treatment trials.

    abstract::Pregnancy outcomes and adverse outcomes in infertility trials are reported to varying extents; for example, 35% of clinical trials reported no information on pregnancy loss, only 43% reported adverse events during the preconception treatment period, and only 7% reported any serious adverse events. Incomplete reporting...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,评审


    authors: Dapuzzo L,Seitz FE,Dodson WC,Stetter C,Kunselman AR,Legro RS

    更新日期:2011-06-30 00:00:00

  • Using semen flow cytometry to evaluate association of ploidy status and chromatin condensation of spermatozoa with conventional semen parameters: clinical application in intrauterine insemination.

    abstract:OBJECTIVE:To evaluate the association between the ploidy status and the nuclear chromatin condensation of spermatozoa with conventional semen parameters by using semen flow cytometry (SFC). The prognostic value of SFC on the successful outcome of intrauterine insemination (IUI) was examined. DESIGN:Prospective study. ...

    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章


    authors: Lazaros L,Kaponis A,Vartholomatos G,Hatzi E,Botsari S,Plachouras N,Makrydimas G,Zikopoulos K,Sofikitis N,Georgiou I

    更新日期:2011-01-01 00:00:00

  • Cryptorchidism in the subfertile male.

    abstract::Certain conclusions may be drawn from the present review and presentation of new data concerning the unilaterally cryptorchid patient and possible subfertility: 1. The truly undescended testis--not the retractile testis of infancy--will not descend spontaneously after 1 year of age. 2. The seminal quality of the unila...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Lipshultz LI

    更新日期:1976-06-01 00:00:00

  • Semen quality in men with disseminated testicular cancer: relation with human chorionic gonadotropin beta-subunit and pituitary gonadal hormones.

    abstract:OBJECTIVE:To compare the semen quality and hormonal status between patients with testicular cancer and normal versus increased serum levels of beta-hCG. DESIGN:Retrospective study. SETTING:Academic research environment. PATIENT(S):All 203 patients with testicular cancer who required chemotherapy in the period 1995-2...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: de Bruin D,de Jong IJ,Arts EG,Nuver J,Dullaart RP,Sluiter WJ,Hoekstra HJ,Sleijfer DT,Gietema JA

    更新日期:2009-06-01 00:00:00

  • Effect of body weight on early hormone levels in singleton pregnancies resulting in delivery after in vitro fertilization.

    abstract:OBJECTIVE:To evaluate which clinical characteristics influence early maternal β-human chorionic gonadotropin (hCG) and progesterone levels in in vitro fertilization (IVF) pregnancies. DESIGN:Retrospective cohort analysis. SETTING:Academic medical center. PATIENT(S):Women with a live birth after single-blastocyst emb...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Mejia RB,Cox TW,Nguyen EB,Summers KM,Eyck PT,Sparks AE,Van Voorhis BJ

    更新日期:2018-12-01 00:00:00

  • Clinical management of mosaic results from preimplantation genetic testing for aneuploidy (PGT-A) of blastocysts: a committee opinion.

    abstract::Since the advent of preimplantation genetic testing for aneuploidy (PGT-A) in the 1990s, substantial changes in test methodology and technology now allow the detection and reporting of intermediate chromosome copy number (commonly referred to as mosaicism) for aneuploidy in a trophectoderm biopsy sample. Clinicians ar...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Practice Committee and Genetic Counseling Professional Group (GCPG) of the American Society for Reproductive Medicine. Electronic address:

    更新日期:2020-08-01 00:00:00

  • Angiopoietin 1 and angiopoietin 2 in follicular fluid of women undergoing a long protocol.

    abstract:OBJECTIVE:To determine the concentrations of angiopoietin 1 (ANGPT1) and ANGPT2 in individual human preovulatory follicles in relation to their diameter or volume to clarify the role of these molecules in folliculogenesis. DESIGN:Prospective study. SETTING:Research laboratory at Kansai Medical University, Osaka, Japa...

    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章


    authors: Nishigaki A,Okada H,Tsuzuki T,Cho H,Yasuda K,Kanzaki H

    更新日期:2011-12-01 00:00:00

  • Changes in plasma müllerian-inhibiting substance and brain-derived neurotrophic factor after chemotherapy in premenopausal women.

    abstract::Eight premenopausal women with cancer had blood drawn for analysis of brain-derived neurotrophic factor (BDNF) and müllerian-inhibiting substance (MIS) before and 3 months after receiving chemotherapy. Unlike MIS, BDNF levels were not reduced after chemotherapy. ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Aslam MF,Merhi ZO,Ahmed S,Kuzbari O,Seifer DB,Minkoff H

    更新日期:2011-04-01 00:00:00

  • Role of mitotic control in spermatogenesis.

    abstract:OBJECTIVE:To study the correlation between the incidence of sex chromosome aneuploidies in the somatic cells and spermatozoa in karyotypically normal infertile men and fertile donors. DESIGN:A prospective, phase two, controlled study. SETTING:A teaching Hospital Reproductive Medicine and Medical Genetics Units. PATI...

    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章


    authors: Gazvani MR,Wilson ED,Richmond DH,Howard PJ,Kingsland CR,Lewis-Jones DI

    更新日期:2000-08-01 00:00:00

  • Antiestrogenic action of high-dose clomiphene in primates pituitary augmentation but with ovarian attenuation.

    abstract::Since the dominant follicle is selected by days 5 to 7 of the menstrual cycle, we assessed the differential effects of high-dose clomiphene (25 mg daily) by giving 5-day courses either before (days 1 to 5), during (days 5 to 9), or after (days 9 to 13) emergence of the selected dominant follicle in monkeys. Peripheral...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Marut EL,Hodgen GD

    更新日期:1982-07-01 00:00:00

  • Future fertility after prenatal exposure to cigarette smoke.

    abstract::We tested the hypothesis that prenatal exposure to cigarette smoke is associated with impaired fertility in adulthood. Fertility for nearly 600 couples was quantified by counting the number of noncontraception cycles required to conceive. Exposure in utero was assessed by asking couples about their parents' cigarette ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Baird DD,Wilcox AJ

    更新日期:1986-09-01 00:00:00

  • Can an educational DVD improve the acceptability of elective single embryo transfer? A randomized controlled study.

    abstract:OBJECTIVE:To assess whether provision of an educational DVD was more effective in increasing the uptake of elective single embryo transfers (eSET) than an educational brochure in an IVF population. DESIGN:Randomized controlled trial. SETTING:Private IVF clinic. PATIENT(S):One hundred thirty-one couples starting thei...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,随机对照试验


    authors: Hope N,Rombauts L

    更新日期:2010-07-01 00:00:00

  • Effects of melatonin on histomorphology and on the expression of steroid receptors, VEGF, and PCNA in ovaries of pinealectomized female rats.

    abstract:OBJECTIVE:To evaluate the effect of melatonin both on the ovaries of pinealectomized female rats through histomorphometric analysis and on steroid receptors, proliferating cell nuclear antigen (PCNA), and vascular endothelial growth factor (VEGF) expression. DESIGN:Experimental study. SETTING:Federal University of Sã...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Romeu LR,da Motta EL,Maganhin CC,Oshima CT,Fonseca MC,Barrueco KF,Simões RS,Pellegrino R,Baracat EC,Soares-Junior JM

    更新日期:2011-03-15 00:00:00

  • Different plasma neuropeptide Y concentrations in women athletes with and without menstrual cyclicity.

    abstract::The circulating levels of leptin and neuropeptide Y, which are both involved in the control of feeding and reproduction, were measured in amenorrheic and normal cycling highly trained women athletes, and in normal cycling sedentary controls. Leptin showed similar low values in all athletes, whereas neuropeptide Y leve...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Coiro V,Chiodera P,Melani A,Manfredi G,Saccani Jotti G,Casti A

    更新日期:2006-03-01 00:00:00

  • Assessing loss of imprint methylation in sperm from subfertile men using novel methylation polymerase chain reaction Luminex analysis.

    abstract:OBJECTIVE:To assess the clinical value of bisulfite polymerase chain reaction Luminex (BPL), an automated, high-throughput procedure for the detection of alterations in DNA methylation. DESIGN:Experimental prospective study. SETTING:University research laboratory and private in vitro fertilization (IVF) clinic. PATI...

    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章


    authors: Sato A,Hiura H,Okae H,Miyauchi N,Abe Y,Utsunomiya T,Yaegashi N,Arima T

    更新日期:2011-01-01 00:00:00