Abstract：
OBJECTIVE:To evaluate the association between genetic variants in Ser-Arg (SR) protein-coding genes and the susceptibility of nonobstructive azoospermia (NOA) in Chinese men. DESIGN:Case-control study. SETTING:State Key Laboratory of Reproductive Medicine in Nanjing Medical University conducted the genotyping and examined the expression levels of genes. PATIENT(S):The study included 962 NOA patients and 1,931 control subjects. INTERVENTION(S):None. MAIN OUTCOME MEASURE(S):Genotyping of 16 single-nucleotide polymorphisms (SNPs) of eight "canonic" SR protein-coding genes were performed with the use of the Illumina Infinium Beadchip platform. Odds ratios were calculated by logistic regression analysis in the additive model. Expression levels were measured by quantitative reverse-transcription polymerase chain reaction. RESULT(S):Rs17431717 near SFRS9 and rs12046213 near SFRS4 were significantly associated with a decreased risk of NOA, whereas rs10849753 near SFRS9 and rs6103330 in SFRS6 were associated with an increased risk of NOA. Of the two SNPs in SFRS9, only rs17431717 remained significant after conditioning on another. Combined analysis of three promising SNPs (rs17431717, rs12046213, and rs6103330) showed that compared with individuals with "0-2" risk alleles, those carrying "3," "4," and "≥ 5" risk alleles had 1.22-, 1.38-, and 1.90-fold increased risk of NOA, respectively. CONCLUSION(S):Polymorphisms in SR protein-coding genes may contribute to the risk of NOA in Chinese men. The findings of this study can help us to further understand the etiology of spermatogenic impairment, and they provide more evidence for the role of splicing activity in human spermatogenesis.
journal_name
Fertil Steriljournal_title
Fertility and sterilityauthors
Ni B,Ma H,Lin Y,Dai J,Guo X,Xia Y,Sha J,Hu Zdoi
10.1016/j.fertnstert.2014.02.033subject
Has Abstractpub_date
2014-06-01 00:00:00pages
1711-7.e1-2issue
6eissn
0015-0282issn
1556-5653pii
S0015-0282(14)00186-1journal_volume
101pub_type
杂志文章abstract：:We present a case of combined intrauterine and cornual (interstitial) pregnancy after IVF-ET, with survival of the infant after the cornual pregnancy. The diagnosis of this rare phenomenon is difficult; a high index of suspicion and frequently ultrasound monitoring may enable early diagnosis in other forms of heteroto...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)53473-6
更新日期：1990-04-01 00:00:00
abstract：:Obesity seems to exert a small but important extraovarian effect that may influence cycle outcome during assisted reproduction. Future investigation should focus on elucidating whether the endometrium is truly responsible for this deficit, and if it is, determining the mechanisms involved. ...
journal_title：Fertility and sterility
pub_type： 评论,杂志文章
doi：10.1016/j.fertnstert.2007.03.079
更新日期：2008-06-01 00:00:00
abstract：:The effects of freezing and thawing (F/T) on functional activity of immature rat oocyte-cumulus complexes (OCC) were studied. The OCC were divided into three groups according to the number of cumulus-cell layers surrounding them. The OCC were then frozen and thawed (F/T), with dimethyl sulfoxide (DMSO) as cryoprotecta...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：
更新日期：1988-11-01 00:00:00
abstract：OBJECTIVE:To measure free T, free E2, and sex hormone-binding globulin (SHBG) levels in oligozoospermic men with varicoceles. DESIGN:Retrospective study. PATIENTS:Sixty-four infertile patients with varicoceles. SETTING:A university-based tertiary care referral center. INTERVENTIONS:Assessment of seminal cellular ch...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：
更新日期：1996-08-01 00:00:00
abstract：OBJECTIVE:To report on chronic urinary retention after surgery for deep endometriosis and the possible risk factors for this complication. DESIGN:Descriptive study. SETTING:University hospital. PATIENT(S):Four patients with deep endometriosis who developed this complication. INTERVENTION(S):Laparoscopic surgery, in...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2010.07.1043
更新日期：2011-02-01 00:00:00
abstract：:The effect of danazol on steroidogenesis in cultured human granulosa cells was studied. Granulosa cells obtained from antral follicles in the mid to late follicular phase were cultured for 2 to 6 days. Danazol (0.1 to 5 micrograms/ml) and human chorionic gonadotropin (hCG, 10 IU/ml), alone or in combination, were adde...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：
更新日期：1986-08-01 00:00:00
abstract：OBJECTIVE:To test the hypothesis that, in couples with unexplained infertility, tubal flushing with an oil-soluble media (lipiodol) would increase the pregnancy rate within 6 months compared with expectant management. DESIGN:A prospective, randomized, controlled study in which couples were allocated to either a single...
journal_title：Fertility and sterility
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1016/s0015-0282(01)02925-9
更新日期：2002-01-01 00:00:00
abstract：:The acrosome reaction of human spermatozoa incubated in the presence or absence of vested human oocytes was investigated. All gametes were obtained from human in vitro fertilization (IVF) cases. Spermatozoa were collected after incubation in insemination medium only and following removal of the oocytes from inseminati...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)60379-5
更新日期：1988-12-01 00:00:00
abstract：OBJECTIVE:To describe the treatments of a patient using the laparoscopic Davydov's method for Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome and ureteral reimplantation for hydronephrosis and hydroureter. DESIGN:Surgical video article. A consent form from the patient was obtained as appropriate; the nature of the stud...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2020.08.1433
更新日期：2020-10-14 00:00:00
abstract：:Insulin-like growth factor I (IGF-I) has been proposed to be an autocrine/paracrine factor involved in granulosa cell proliferation and differentiation. The present study focuses on a possible mitogenic effect of IGF-I in human granulosa cells. Insulin-like growth factor I (1 to 10 ng/mL) significantly stimulated 3H-t...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：
更新日期：1990-12-01 00:00:00
abstract：:Sperm banking with the relatively simple and economical biologic freezer (Linde BF-5; Union Carbide Corporation, Linde Division, New York, N.Y.) was compared with controlled-rate freezer (Linde CRF-1; Union Carbide), using different freezing rates and cryoprotective media. The results were assessed by comparing prefre...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：
更新日期：1981-05-01 00:00:00
abstract：:A case of intramural but not interstitial pregnancy, established after IVF/ET, is described. The etiologic, diagnostic, and therapeutic aspects of this clinical dilemma are discussed. ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)54804-3
更新日期：1992-01-01 00:00:00
abstract：OBJECTIVE:To establish the relative frequency of aneuploidy in sperm from normal and abnormal subjects using dual color fluorescence in situ hybridization and probes for six different chromosomes. DESIGN:Semen from 33 normal males and a patient with a translocation was studied using dual color fluorescence in situ hyb...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)56896-4
更新日期：1994-08-01 00:00:00
abstract：OBJECTIVE:To report the case of an infertile female patient with cystic fibrosis who was diagnosed with endocervical metaplasia of the endometrium at diagnostic hysteroscopy and successfully treated with an oral estroprogestinic formulation. DESIGN:Case report. SETTING:University hospital. PATIENT(S):A 27-year-old i...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2005.07.1336
更新日期：2006-03-01 00:00:00
abstract：OBJECTIVE:To determine the meiotic segregation of a pericentric inversion of chromosome 8 in three carriers. DESIGN:Analysis of sperm nuclei by fluorescence in situ hybridization (FISH). SETTING:University hospital. PATIENT(S):Three males with an inv(8). INTERVENTION(S):Triple FISH with the 8q and 8p subtelomeres a...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2007.04.056
更新日期：2008-06-01 00:00:00
abstract：:We found the prevalence of ovarian cancer in infertile women less than 40 years at the time of planned microsurgery for infertility to be 1 in 95. This may represent a greater prevalence of ovarian cancer than that of all women less than 40 years. Importantly, laparoscopy did not find the ovarian cancer in these women...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：
更新日期：1988-03-01 00:00:00
abstract：:Whatever the mechanism of such improvements may be, the results in this study point out that coitus interruptus in the human may not be the method of choice for collection of semen specimens, especially in patients with spermatogenic dysfunctions such as hypospermia, oligospermia, and asthenospermia. It should also be...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)56779-x
更新日期：1994-06-01 00:00:00
abstract：:Many women now choose to develop their careers before having children. Thus, it is becoming increasingly important to assess a woman's potential for extended fertility and to understand the health consequences of having children at a late age. In particular, there is a striking positive correlation between extended fe...
journal_title：Fertility and sterility
pub_type： 杂志文章,评审
doi：10.1016/j.fertnstert.2015.02.008
更新日期：2015-05-01 00:00:00
abstract：:Inflammatory exudates around intrauterine devices were found to produce large concentrations of prostaglandin F2alpha. To evaluate the effect of this substance, 100 semen specimens were incubated in concentrations 100 times greater than that found in normal semen. Motility indices were calculated, and significant inhi...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：
更新日期：1977-01-01 00:00:00
abstract：OBJECTIVE:To determine the efficacy and safety of Repronex SC as compared with Repronex IM and Pergonal IM in patients undergoing IVF. DESIGN:Open-label, randomized, parallel-group, multicenter study. SETTING:Fifteen academic and private fertility clinics with IVF experience. PATIENT(S):Premenopausal women with regu...
journal_title：Fertility and sterility
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1016/s0015-0282(00)00605-1
更新日期：2000-07-01 00:00:00
abstract：:This prospective study evaluated the efficacy of transvaginal ultrasonography combined with water-contrast in the rectum (RWC-TVS) in the diagnosis of rectal infiltration in 35 women with rectovaginal endometriosis; ultrasonographic findings were compared with surgery and histology. The sensitivity of RWC-TVS in ident...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2007.07.1336
更新日期：2008-03-01 00:00:00
abstract：:Repetitively short luteal phases were found in eight infertile women. The short luteal phase was defined as 10 days or less from the presumed time of ovulation (as assessed by basal body temperature recording) to the onset of menses. Clomiphene citrate (Clomid) therapy resulted in pregnancy in two patients and lengthe...
journal_title：Fertility and sterility
pub_type： 临床试验,杂志文章
doi：10.1016/s0015-0282(16)43930-0
更新日期：1979-04-01 00:00:00
abstract：OBJECTIVE:To compare the performance of the SureView catheter, a new ultrasonic embryo transfer (ET), with the classic Wallace catheter during ultrasound-guided ET. DESIGN:Prospective, randomized study. SETTING:Private, academically affiliated clinic. PATIENT(S):175 patients undergoing donor egg in vitro fertilizati...
journal_title：Fertility and sterility
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.fertnstert.2009.01.090
更新日期：2010-02-01 00:00:00
abstract：OBJECTIVE:To assess the impact on women's reproductive outcomes of barbed sutures to repair uterine breaches during laparoscopic myomectomy compared with traditional smooth sutures. DESIGN:Retrospective, monocentric cohort study, with information on subsequent pregnancies prospectively acquired for some women. SETTIN...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2020.07.036
更新日期：2021-01-01 00:00:00
abstract：OBJECTIVE:To investigate whether Kremer's sperm-mucus penetration test may predict sperm fertilizing ability in IVF. DESIGN:Kremer's test was prospectively performed on semen samples used for 66 consecutive IVF trials and compared with the fertilization rates and fertilization failure rates observed. RESULTS:Fertiliz...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)55981-0
更新日期：1993-06-01 00:00:00
abstract：:Eighty-seven patients who underwent a late secretory phase endometrial biopsy while taking clomiphene citrate (CC) for ovulation induction were studied. Of the endometrial biopsies, 21 (24%) showed an endometrium greater than 2 days out of phase (OOP) with respect to the subsequent menstrual cycle. All 87 patients wer...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)60726-4
更新日期：1989-06-01 00:00:00
abstract：OBJECTIVE:To study the effects of varicocele on testicular function in adolescents. DESIGN:A prospective controlled study in 88 randomly selected adolescents. SETTING:All participants were referred to the fertility outpatient clinic of our University Hospital. PARTICIPANTS:All participants with a grade II varicocele...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)54607-x
更新日期：1991-10-01 00:00:00
abstract：:Cooling experiments of abdominal testes in adult, naturally cryptorchid pigs indicate that spermatogenic arrest in abdominal testes is not due to an inborn defect, but is caused solely by maintenance of the testis at abdominal temperature. It is postulated that failure of spermatogenic cells to differentiate after orc...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)44364-5
更新日期：1979-11-01 00:00:00
abstract：:Many studies evaluating a possible relationship between inherited thrombophilia and the etiology of unexplained infertility have been performed recently. No significant difference in the prevalence of three genetic mutations associated with the increased risk of thrombophilia (Factor V Leiden G1691A, prothrombin G2021...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2009.10.014
更新日期：2010-07-01 00:00:00
abstract：:Two male cousins with partial 21-hydroxylase deficiency presented with bilateral testicular masses and infertility. In both cases, the testicular masses, consisting of adrenocorticotropic hormone-dependent pluripotential cells, were thought to play a major etiologic role in infertility. The administration of very smal...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)47485-6
更新日期：1983-12-01 00:00:00
