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Effect of insulin-like growth factor I on deoxyribonucleic acid synthesis in cultured human granulosa cells.

Abstract：

:Insulin-like growth factor I (IGF-I) has been proposed to be an autocrine/paracrine factor involved in granulosa cell proliferation and differentiation. The present study focuses on a possible mitogenic effect of IGF-I in human granulosa cells. Insulin-like growth factor I (1 to 10 ng/mL) significantly stimulated 3H-thymidine incorporation in granulosa cells obtained from both natural cycles and from patients stimulated for in vitro fertilization, whereas luteinizing hormone (LH, 10 ng/mL), follicle-stimulating hormone (FSH, 10 ng/mL) and epidermal growth factor (EGF, 10 ng/mL) had no apparent effect on deoxyribonucleic acid (DNA) synthesis under these conditions. Luteinizing hormone and FSH stimulated progesterone secretion whereas IGF-I and EGF were without effect. Our observations that IGF-I stimulates DNA synthesis in human granulosa cells is in agreement with previous reports, in other species, indicating that IGF-I might be of importance for granulosa cell proliferation.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Olsson JH,Carlsson B,Hillensjö T

subject

Has Abstract

pub_date

1990-12-01 00:00:00

pages

1052-7

issue

6

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(16)54004-7

journal_volume

54

pub_type

杂志文章

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